Therapeutic angiogenesis by autologous transplantation of bone marrow mononuclear cells for peripheral artery disease

2007 ◽  
Vol 1299 ◽  
pp. 203-209 ◽  
Author(s):  
Kazuhiro Nagai ◽  
Ichiroh Matsumaru ◽  
Takuya Fukushima ◽  
Yasushi Miyazaki ◽  
Hiroichiroh Yamaguchi ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Peripheral Artery Disease ◽  
Mononuclear Cells ◽  
Autologous Transplantation ◽  
Therapeutic Angiogenesis ◽  
Bone Marrow Mononuclear Cells ◽  
Peripheral Artery ◽  
Artery Disease

scholarly journals Gene Therapy and Cell-Based Therapies for Therapeutic Angiogenesis in Peripheral Artery Disease

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Munehisa Shimamura ◽  
Hironori Nakagami ◽  
Hiroshi Koriyama ◽  
Ryuichi Morishita
Keyword(s):  
Gene Therapy ◽  
Growth Factor ◽  
Peripheral Artery Disease ◽  
Mononuclear Cells ◽  
Therapeutic Angiogenesis ◽  
Novel Therapies ◽  
Peripheral Artery ◽  
Peripheral Blood Mononuclear ◽  
Cell Based Therapy ◽  
Artery Disease

Gene therapy and cell-based therapy have emerged as novel therapies to promote therapeutic angiogenesis in critical limb ischemia (CLI) caused by peripheral artery disease (PAD). Although researchers initially focused on gene therapy using proangiogenic factors, such as vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), and hepatocyte growth factors (HGF), cell therapy using bone marrow mononuclear cells (BMMNCs), mesenchymal stem cells (BMMSCs), G-CSF-mobilized peripheral blood mononuclear cells (M-PBMNCs), and endothelial progenitor cells (EPCs) have also been extensively studied. Based on the elaborate studies and favorable results of basic research, some clinical phase I/II trials have been performed, and the results demonstrate the safety of these approaches and their potential for symptomatic improvement in CLI. However, the phase 3 clinical trials have thus far been limited to gene therapy using the HGF gene. Further studies using well-designed larger placebo-controlled and long-term randomized control trials (RCTs) will clarify the effectiveness of gene therapy and cell-based therapy for the treatment of CLI. Furthermore, the development of efficient gene transfer systems and effective methods for keeping transplanted cells healthy will make these novel therapies more effective and ease the symptoms of CLI.

Arterial Gene Therapy for Therapeutic Angiogenesis in Patients With Peripheral Artery Disease

Circulation ◽  
1995 ◽  
Vol 91 (11) ◽  
pp. 2687-2692 ◽  
Author(s):  
Jeffrey M. Isner ◽  
Kenneth Walsh ◽  
James Symes ◽  
Ann Pieczek ◽  
Satoshi Takeshita ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Peripheral Artery Disease ◽  
Therapeutic Angiogenesis ◽  
Peripheral Artery ◽  
Artery Disease

Peripheral-blood or bone-marrow mononuclear cells for therapeutic angiogenesis?

The Lancet ◽  
2002 ◽  
Vol 360 (9350) ◽  
pp. 2083 ◽  
Author(s):  
Shoichi Inaba ◽  
Kensuke Egashira ◽  
Kimihiro Komori
Keyword(s):  
Bone Marrow ◽  
Peripheral Blood ◽  
Mononuclear Cells ◽  
Therapeutic Angiogenesis ◽  
Bone Marrow Mononuclear Cells

scholarly journals Molecular Imaging of Bone Marrow Mononuclear Cell Survival and Homing in Murine Peripheral Artery Disease

2012 ◽  
Vol 5 (1) ◽  
pp. 46-55 ◽  
Author(s):  
Koen E.A. van der Bogt ◽  
Alwine A. Hellingman ◽  
Maarten A. Lijkwan ◽  
Ernst-Jan Bos ◽  
Margreet R. de Vries ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Molecular Imaging ◽  
Cell Survival ◽  
Mononuclear Cell ◽  
Peripheral Artery Disease ◽  
Bone Marrow Mononuclear Cell ◽  
Peripheral Artery ◽  
Artery Disease

scholarly journals Targets and delivery methods for therapeutic angiogenesis in peripheral artery disease

2012 ◽  
Vol 17 (3) ◽  
pp. 174-192 ◽  
Author(s):  
Geoffrey O Ouma ◽  
Rebecca A Jonas ◽  
M Haris U Usman ◽  
Emile R Mohler
Keyword(s):  
Peripheral Artery Disease ◽  
Therapeutic Angiogenesis ◽  
Peripheral Artery ◽  
Delivery Methods ◽  
Artery Disease

scholarly journals Unblinded Pilot Study of Autologous Transplantation of Bone Marrow Mononuclear Cells in Patients With Thromboangiitis Obliterans

Circulation ◽  
2006 ◽  
Vol 114 (24) ◽  
pp. 2679-2684 ◽  
Author(s):  
Koji Miyamoto ◽  
Kazuhiro Nishigami ◽  
Noritoshi Nagaya ◽  
Koichi Akutsu ◽  
Masaaki Chiku ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Pilot Study ◽  
Mononuclear Cells ◽  
Autologous Transplantation ◽  
Thromboangiitis Obliterans ◽  
Bone Marrow Mononuclear Cells

Therapeutic angiogenesis for revascularization in peripheral artery disease

Gene ◽  
2013 ◽  
Vol 525 (2) ◽  
pp. 220-228 ◽  
Author(s):  
Anna Grochot-Przeczek ◽  
Jozef Dulak ◽  
Alicja Jozkowicz
Keyword(s):  
Peripheral Artery Disease ◽  
Therapeutic Angiogenesis ◽  
Peripheral Artery ◽  
Artery Disease

scholarly journals Impaired Regeneration Contributes to Poor Outcomes in Diabetic Peripheral Artery Disease

2020 ◽  
Vol 40 (1) ◽  
pp. 34-44 ◽  
Author(s):  
Gian Paolo Fadini ◽  
Gaia Spinetti ◽  
Marianna Santopaolo ◽  
Paolo Madeddu
Keyword(s):  
Diabetes Mellitus ◽  
Bone Marrow ◽  
Peripheral Artery Disease ◽  
Local Level ◽  
Negative Influence ◽  
Peripheral Artery ◽  
Ischemic Complications ◽  
Artery Disease ◽  
Poor Outcomes ◽  
Novel Concept

Diabetes mellitus increases the risk and accelerates the course of peripheral artery disease, making patients more susceptible to ischemic events and infections and delaying tissue healing. Current understanding of pathogenic mechanisms is mainly based on the negative influence of diabetes mellitus on atherosclerotic disease and inflammation. In recent years, the novel concept that diabetes mellitus can impinge on endogenous regenerative processes has been introduced. Diabetes mellitus affects regeneration at the local level, disturbing proper angiogenesis, collateral artery formation, and muscle repair. Recent evidence indicates that an impairment in vascular mural cells, alias pericytes, may participate in diabetic peripheral vasculopathy. Moreover, the bone marrow undergoes a global remodeling, consisting of microvessels and sensory neurons rarefaction and fat accumulation, which creates a hostile microenvironment for resident stem cells. Bone marrow remodeling is also responsible for detrimental systemic effects. In particular, the aid of reparative cells from the bone marrow is compromised: these elements are released in an improper manner and become harmful vectors of inflammatory and antiangiogenic molecules and noncoding RNAs. This new understanding of impaired regeneration is inspiring new therapeutic options for the treatment of ischemic complications in people with diabetes mellitus.

Sign in / Sign up

Export Citation Format

Share Document