T-cell mimicry of streptococcal M protein and cardiac myosin epitopes by T-cell clones from rheumatic heart disease

2006 ◽  
Vol 1289 ◽  
pp. 296-299
Author(s):  
Nadia M.J. Ellis ◽  
Ya Li ◽  
William Hildebrand ◽  
Vincent A. Fischetti ◽  
Madeleine W. Cunningham
Keyword(s):  
Heart Disease ◽  
T Cell ◽  
Rheumatic Heart Disease ◽  
M Protein ◽  
Cardiac Myosin ◽  
T Cell Clones ◽  
Streptococcal M Protein ◽  
Cell Clones ◽  
Rheumatic Heart

scholarly journals Mimicry in Recognition of Cardiac Myosin Peptides by Heart-Intralesional T Cell Clones from Rheumatic Heart Disease

2006 ◽  
Vol 176 (9) ◽  
pp. 5662-5670 ◽  
Author(s):  
Kellen C. Faé ◽  
Danielle Diefenbach da Silva ◽  
Sandra E. Oshiro ◽  
Ana C. Tanaka ◽  
Pablo M. A. Pomerantzeff ◽  
...  
Keyword(s):  
Heart Disease ◽  
T Cell ◽  
Rheumatic Heart Disease ◽  
Cardiac Myosin ◽  
T Cell Clones ◽  
Cell Clones ◽  
Rheumatic Heart

Human Heart–Infiltrating T-Cell Clones From Rheumatic Heart Disease Patients Recognize Both Streptococcal and Cardiac Proteins

Circulation ◽  
1995 ◽  
Vol 92 (3) ◽  
pp. 415-420 ◽  
Author(s):  
L. Guilherme ◽  
E. Cunha-Neto ◽  
V. Coelho ◽  
R. Snitcowsky ◽  
P. M. A. Pomerantzeff ◽  
...  
Keyword(s):  
Heart Disease ◽  
T Cell ◽  
Rheumatic Heart Disease ◽  
Human Heart ◽  
T Cell Clones ◽  
Cell Clones ◽  
Rheumatic Heart

scholarly journals T-Cell Reactivity against Streptococcal Antigens in the Periphery Mirrors Reactivity of Heart-Infiltrating T Lymphocytes in Rheumatic Heart Disease Patients

2001 ◽  
Vol 69 (9) ◽  
pp. 5345-5351 ◽  
Author(s):  
Luiza Guilherme ◽  
Sandra E. Oshiro ◽  
Kellen C. Faé ◽  
Edécio Cunha-Neto ◽  
Guilherme Renesto ◽  
...  
Keyword(s):  
T Cells ◽  
Heart Disease ◽  
T Cell ◽  
Rheumatic Heart Disease ◽  
Peripheral Blood ◽  
Cell Reactivity ◽  
T Cell Clones ◽  
Cell Clones ◽  
T Cell Reactivity ◽  
Rheumatic Heart

ABSTRACT T-cell molecular mimicry between streptococcal and heart proteins has been proposed as the triggering factor leading to autoimmunity in rheumatic heart disease (RHD). We searched for immunodominant T-cell M5 epitopes among RHD patients with defined clinical outcomes and compared the T-cell reactivities of peripheral blood and intralesional T cells from patients with severe RHD. The role of HLA class II molecules in the presentation of M5 peptides was also evaluated. We studied the T-cell reactivity against M5 peptides and heart proteins on peripheral blood mononuclear cells (PBMC) from 74 RHD patients grouped according to the severity of disease, along with intralesional and peripheral T-cell clones from RHD patients. Peptides encompassing residues 1 to 25, 81 to 103, 125 to 139, and 163 to 177 were more frequently recognized by PBMC from RHD patients than by those from controls. The M5 peptide encompassing residues 81 to 96 [M5(81–96) peptide] was most frequently recognized by PBMC from HLA-DR7+DR53+ patients with severe RHD, and 46.9% (15 of 32) and 43% (3 of 7) of heart-infiltrating and PBMC-derived peptide-reactive T-cell clones, respectively, recognized the M5(81–103) region. Heart proteins were recognized more frequently by PBMC from patients with severe RHD than by those from patients with mild RHD. The similar pattern of T-cell reactivity found with both peripheral blood and heart-infiltrating T cells is consistent with the migration of M-protein-sensitized T cells to the heart tissue. Conversely, the presence of heart-reactive T cells in the PBMC of patients with severe RHD also suggests a spillover of sensitized T cells from the heart lesion.

scholarly journals T Cell Mimicry and Epitope Specificity of Cross-Reactive T Cell Clones from Rheumatic Heart Disease

2005 ◽  
Vol 175 (8) ◽  
pp. 5448-5456 ◽  
Author(s):  
Nadia M. J. Ellis ◽  
Ya Li ◽  
William Hildebrand ◽  
Vincent A. Fischetti ◽  
Madeleine W. Cunningham
Keyword(s):  
Heart Disease ◽  
T Cell ◽  
Rheumatic Heart Disease ◽  
T Cell Clones ◽  
Epitope Specificity ◽  
Cell Clones ◽  
Rheumatic Heart

scholarly journals Repeat exposure to group A streptococcal M protein exacerbates cardiac damage in a rat model of rheumatic heart disease

Autoimmunity ◽  
2016 ◽  
Vol 49 (8) ◽  
pp. 563-570 ◽  
Author(s):  
Davina Gorton ◽  
Suchandan Sikder ◽  
Natasha L. Williams ◽  
Lisa Chilton ◽  
Catherine M. Rush ◽  
...  
Keyword(s):  
Heart Disease ◽  
Rheumatic Heart Disease ◽  
Rat Model ◽  
M Protein ◽  
Cardiac Damage ◽  
Streptococcal M Protein ◽  
Repeat Exposure ◽  
Group A ◽  
Rheumatic Heart

scholarly journals Concerns for efficacy of a 30-valent M-protein-based Streptococcus pyogenes vaccine in regions with high rates of rheumatic heart disease

2019 ◽  
Vol 13 (7) ◽  
pp. e0007511 ◽  
Author(s):  
Philip M. Giffard ◽  
Steven Y. C. Tong ◽  
Deborah C. Holt ◽  
Anna P. Ralph ◽  
Bart J. Currie
Keyword(s):  
Heart Disease ◽  
Rheumatic Heart Disease ◽  
Streptococcus Pyogenes ◽  
M Protein ◽  
Rheumatic Heart
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