Population studies using single nucleotide polymorphisms—how important is detailed sample origin information?

2004 ◽  
Vol 1261 ◽  
pp. 30-32
Author(s):  
C. Thacker ◽  
C. Harrison ◽  
M. Brion ◽  
C. Phillips ◽  
P. Sanchez-Diz ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Population Studies ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide

Genotyping single nucleotide polymorphisms in barley by tetra-primer ARMS–PCR

Genome ◽  
2004 ◽  
Vol 47 (2) ◽  
pp. 414-420 ◽  
Author(s):  
E Chiapparino ◽  
D Lee ◽  
P Donini
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Dna Sequences ◽  
Population Studies ◽  
Great Increase ◽  
Nucleotide Polymorphisms ◽  
Database Mining ◽  
Single Nucleotide ◽  
Detection Systems ◽  
Arms Pcr ◽  
Agronomically Important Traits

Single nucleotide polymorphisms (SNPs) are the most abundant form of DNA polymorphism. These polymorphisms can be used in plants as simple genetic markers for many breeding applications, for population studies, and for germplasm fingerprinting. The great increase in the available DNA sequences in the databases has made it possible to identify SNPs by "database mining", and the single most important factor preventing their widespread use appears to be the genotyping cost. Many genotyping platforms rely on the use of sophisticated, automated equipment coupled to costly chemistry and detection systems. A simple and economical method involving a single PCR is reported here for barley SNP genotyping. Using the tetra-primer ARMS–PCR procedure, we have been able to assay unambiguously five SNPs in a set of 132 varieties of cultivated barley. The results show the reliability of this technique and its potential for use in low- to moderate-throughput situations; the association of agronomically important traits is discussed.Key words: single nucleotide polymorphisms (SNPs), genotyping, barley, tetra-primers ARMS–PCR.

Development of a simple method for the determination of single nucleotide polymorphisms

2010 ◽  
Vol 34 (8) ◽  
pp. S75-S75
Author(s):  
Weifeng Zhu ◽  
Zhuoqi Liu ◽  
Daya Luo ◽  
Xinyao Wu ◽  
Fusheng Wan
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Nucleotide Polymorphisms ◽  
Simple Method ◽  
Single Nucleotide

Sex Differences in Childhood Associations between DNA Markers and General Cognitive Ability

2007 ◽  
Vol 28 (3) ◽  
pp. 161-164 ◽  
Author(s):  
Rosalind Arden ◽  
Nicole Harlaar ◽  
Robert Plomin
Keyword(s):  
Sex Differences ◽  
Single Nucleotide Polymorphisms ◽  
Cognitive Ability ◽  
Dna Markers ◽  
Community Sample ◽  
Nucleotide Polymorphisms ◽  
General Cognitive Ability ◽  
Single Nucleotide ◽  
The Difference

Abstract. An association between intelligence at age 7 and a set of five single-nucleotide polymorphisms (SNPs) has been identified and replicated. We used this composite SNP set to investigate whether the associations differ between boys and girls for general cognitive ability at ages 2, 3, 4, 7, 9, and 10 years. In a longitudinal community sample of British twins aged 2-10 (n > 4,000 individuals), we found that the SNP set is more strongly associated with intelligence in males than in females at ages 7, 9, and 10 and the difference is significant at 10. If this finding replicates in other studies, these results will constitute the first evidence of the same autosomal genes acting differently on intelligence in the two sexes.

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