scholarly journals Perinatal dietary protein deficiency perturbs neurodevelopment and cognitive behavior of F1 and F2-generations of rat models

IBRO Reports ◽  
2019 ◽  
Vol 6 ◽  
pp. S77
Author(s):  
Nosarieme Abey ◽  
Osaretin A.T. Ebuehi ◽  
Ngozi. O.A. Imaga
Keyword(s):  
Dietary Protein ◽  
Protein Deficiency ◽  
Cognitive Behavior ◽  
Rat Models

scholarly journals Perinatal Dietary Protein Deficiency Alters Neurodevelopment and Reproductive Health of F0 and F1-Generations of Sprague-Dawley Rat Models

2020 ◽  
Author(s):  
Abey Nosarieme ◽  
Ebuehi Osaretin
Keyword(s):  
Reproductive Health ◽  
Dietary Protein ◽  
Water Maze ◽  
Reproductive Function ◽  
Protein Deficiency ◽  
Rat Models ◽  
Fertility Index ◽  
Y Maze ◽  
And Control ◽  
The Brain

Maternal and child health has been linked to the development of the human conceptus which absolutely depends on adequate and balanced supplies of key nutrients; therefore, an important element of reproductive health and neurodevelopment is improved nutritional status in women of child bearing age. Defect in neurodevelopment of newborn costs the mother both psychological and emotional stress, also reproductive health failure has been a significant public health concern, because it leads to disability in couples and individuals who bear the burden, there is therefore an urgent need to understand the underlying of birth malformation in order to channel possible solution. This study therefore sought to investigate the reproductive and neurodevelopmental defects in rat models of F 0 , F 1 and F 2 generations after modeled dietary protein deficiency, establishing the consequential mechanistic association. Rats in four groups were fed different ration of protein diet (PD); 21% PD, 10%PD, 5%PD and control diet (Normal rat chow), from adolescent through to gestation and Lactation, and next generations were weaned to the maternal diet group. Reproductive function and fertility index (including oestrus cyclicity, sexual response, histopathology and hormone profiling), as well as Neurobehavioral studies to include; Learning Memory tests (Y-maze, Moriz water maze, Elevated Plus Maze and Open field test) and Brain oxidative stress. Result shows significant reduction in the %fertility index and the overall reproductive function in the protein deficient models (5%PD; 35%2.5 10%PD; 66%2.2 as compared to 21%PD; 88.4%0.8, and control 85.8%1.3) which persist in subsequent generation. There was also observable transgenerational cognitive impairment reflected in: The Y-maze (Spatial memory: 5%; 8.3%, 10%; 9.25% 21%; 57.6% and control 55.95%), Morizz water Maze (5%: 26.5; 10%;21, 21%;5 and control; 6, as escape latency time), there was a significant decrease in the antioxidant capacity of the brain, especially in the 5%PD models. Brain serotonin and dopamine levels respectively; 5%: 2.70.3; 36.25 0.57., 10%; 2.90.3; 17.75 0.94., 21%;7.80.9; 7.951.1., and control; 70.2; 11.550.7. were significantly perturbed in the test model brains. Therefore, Protein deficiency is capable of causing a dysfunction in the reproductive health of models, by altering the oestrus cyclicity which is partly dependent on the changes in hormonal events, the brain redox status and neurotransmitter system. Therefore, persistent perinatal exposure to protein malnutrition increases the risk of cognitive defect and other brain disorders in subsequent generations. There was an evidence of metabolic reset in the malnourished group; this may be due in part to epigenetic regulation of transposable element.

scholarly journals Severe protein deficiency induces hepatic expression and systemic level of FGF21 but inhibits its hypothalamic expression in growing rats

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Joanna Moro ◽  
Catherine Chaumontet ◽  
Patrick C. Even ◽  
Anne Blais ◽  
Julien Piedcoq ◽  
...  
Keyword(s):  
Body Weight ◽  
Food Intake ◽  
Energy Expenditure ◽  
Energy Intake ◽  
Dietary Protein ◽  
Protein Deficiency ◽  
Protein Diet ◽  
Growing Rats ◽  
Low Protein ◽  
Protein Diets

AbstractTo study, in young growing rats, the consequences of different levels of dietary protein deficiency on food intake, body weight, body composition, and energy balance and to assess the role of FGF21 in the adaptation to a low protein diet. Thirty-six weanling rats were fed diets containing 3%, 5%, 8%, 12%, 15% and 20% protein for three weeks. Body weight, food intake, energy expenditure and metabolic parameters were followed throughout this period. The very low-protein diets (3% and 5%) induced a large decrease in body weight gain and an increase in energy intake relative to body mass. No gain in fat mass was observed because energy expenditure increased in proportion to energy intake. As expected, Fgf21 expression in the liver and plasma FGF21 increased with low-protein diets, but Fgf21 expression in the hypothalamus decreased. Under low protein diets (3% and 5%), the increase in liver Fgf21 and the decrease of Fgf21 in the hypothalamus induced an increase in energy expenditure and the decrease in the satiety signal responsible for hyperphagia. Our results highlight that when dietary protein decreases below 8%, the liver detects the low protein diet and responds by activating synthesis and secretion of FGF21 in order to activate an endocrine signal that induces metabolic adaptation. The hypothalamus, in comparison, responds to protein deficiency when dietary protein decreases below 5%.

Effects of dietary protein deficiency on mineral metabolism and bone mineral density

1992 ◽  
Vol 56 (2) ◽  
pp. 314-319 ◽  
Author(s):  
E Orwoll ◽  
M Ware ◽  
L Stribrska ◽  
D Bikle ◽  
T Sanchez ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Dietary Protein ◽  
Mineral Metabolism ◽  
Protein Deficiency ◽  
Mineral Density

Influence of dietary protein deficiency on lead-copper interaction in rats

1989 ◽  
Vol 18 (1) ◽  
pp. 75-82 ◽  
Author(s):  
Swaran J.S. Flora ◽  
Roger A. Coulombe ◽  
Raghubir P. Sharma ◽  
Sushil K. Tandon
Keyword(s):  
Dietary Protein ◽  
Protein Deficiency
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