Mechanisms of Allergen-Specific Immunotherapy: T-Regulatory Cells and More

2006 ◽  
Vol 26 (2) ◽  
pp. 207-231 ◽  
Author(s):  
Johan Verhagen ◽  
Kurt Blaser ◽  
Cezmi A. Akdis ◽  
Mübeccel Akdis
Keyword(s):  
Specific Immunotherapy ◽  
T Regulatory Cells ◽  
Regulatory Cells ◽  
Allergen Specific Immunotherapy

scholarly journals Allergen-specific immunotherapy: an update on immunological mechanisms of action

2016 ◽  
Vol 65 (1) ◽  
Author(s):  
G. Ciprandi ◽  
G.L. Marseglia ◽  
M.A. Tosca
Keyword(s):  
Specific Immunotherapy ◽  
T Regulatory Cells ◽  
Sublingual Immunotherapy ◽  
Mechanisms Of Action ◽  
Regulatory Cells ◽  
Allergen Specific Immunotherapy ◽  
Specific Antibodies ◽  
Immunological Mechanisms ◽  
Specific Igg4 ◽  
History Of

Specific immunotherapy (SIT) is the only treatment able to modify the natural history of the allergic subjects. Several aspects of the immunopathological response modified by SIT have been investigated; the first parameter historically studied was the production of allergen-specific antibodies. An increase of allergen-specific IgG4 and a decrease of IgE appear after SIT. A shift from Th2-polarized immune response toward Th1-oriented pattern has been reported after SIT. More recently, a crucial role for a subpopulation of T cells has been evidenced: T regulatory cells (Treg). Allergic patients have a defect of Tregs. SIT is able of inducing a specific Treg response. Sublingual immunotherapy is an alternative route of administration for SIT. Recent evidence shows that SLIT is also able of inducing a Treg response as detected by IL- 10 production.

T Regulatory Cells in Allergen-Specific Immunotherapy

2005 ◽  
Vol 24 (5-6) ◽  
pp. 533-548 ◽  
Author(s):  
Johan Verhagen ◽  
Alison Taylor ◽  
Kurt Blaser ◽  
Mübeccel Akdis ◽  
Cezmi A. Akdis
Keyword(s):  
Specific Immunotherapy ◽  
T Regulatory Cells ◽  
Regulatory Cells ◽  
Allergen Specific Immunotherapy

Regulatory cells in allergen-specific immunotherapy

Immunotherapy ◽  
2012 ◽  
Vol 4 (4) ◽  
pp. 389-396 ◽  
Author(s):  
Michael B Soyka ◽  
David Holzmann ◽  
Cezmi A Akdis
Keyword(s):  
Specific Immunotherapy ◽  
Regulatory Cells ◽  
Allergen Specific Immunotherapy
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