scholarly journals Acute lymphoblastic leukemia to acute myeloid leukemia: an unusual case report of lineage switching

2020 ◽  
Author(s):  
Sudarshan Pandit ◽  
Nilesh Wasekar ◽  
Girish Badarkhe ◽  
Venkata Ramesh Yasam ◽  
Rajnish Nagarkar
Keyword(s):  
Acute Myeloid Leukemia ◽  
Case Report ◽  
Acute Lymphoblastic Leukemia ◽  
Myeloid Leukemia ◽  
Unusual Case ◽  
Lymphoblastic Leukemia ◽  
Unusual Case Report ◽  
Acute Myeloid

A CLINICOPATHOLOGICAL STUDY OF ACUTE AND CHRONIC LEUKEMIA IN A TERTIARY CARE HOSPITAL

2021 ◽  
pp. 72-74
Author(s):  
Sarat Das ◽  
Prasanta Kr. Baruah ◽  
Sandeep Khakhlari ◽  
Gautam Boro
Keyword(s):  
Acute Myeloid Leukemia ◽  
Acute Lymphoblastic Leukemia ◽  
Peripheral Blood ◽  
Myeloid Leukemia ◽  
Blood Smear ◽  
Lymphoblastic Leukemia ◽  
Peripheral Blood Smear ◽  
Care Hospital ◽  
Cytochemical Study ◽  
Acute Myeloid

Introduction: Leukemias are neoplastic proliferations of haematopoietic stem cells and form a major proportion of haematopoietic neoplasms that are diagnosed worldwide. Typing of leukemia is essential for effective therapy because prognosis and survival rate are different for each type and sub-type Aims: this study was carried out to determine the frequency of acute and chronic leukemias and to evaluate their clinicopathological features. Methods: It was a hospital based cross sectional study of 60 patients carried out in the department of Pathology, JMCH, Assam over a period of one year between February 2018 and January 2019. Diagnosis was based on peripheral blood count, peripheral blood smear and bone marrow examination (as on when available marrow sample) for morphology along with cytochemical study whenever possible. Results: In the present study, commonest leukemia was Acute myeloid leukemia (AML, 50%) followed by Acute lymphoblastic leukemia (ALL 26.6%), chronic myeloid leukemia (CML, 16.7%) and chronic lymphocytic leukemia (CLL, 6.7%). Out of total 60 cases, 36 were male and 24 were female with Male:Female ratio of 1.5:1. Acute lymphoblastic leukemia was the most common type of leukemia in the children and adolescents. Acute Myeloid leukemia was more prevalent in adults. Peripheral blood smear and bone Conclusion: marrow aspiration study still remains the important tool along with cytochemistry, immunophenotyping and cytogenetic study in the diagnosis and management of leukemia.

scholarly journals ultrastrutal investigation on Pseudo Chediak–Higashi abnormality in acute lymphoblastic leukemia: A case report

2021 ◽  
Author(s):  
Jing Liu ◽  
Shu-xu Dong ◽  
Ying Li ◽  
Yi-dan Xu ◽  
Yong-xin Ru
Keyword(s):  
Acute Myeloid Leukemia ◽  
Electron Microscope ◽  
Acute Lymphoblastic Leukemia ◽  
Myeloid Leukemia ◽  
Membrane Structure ◽  
Lymphoblastic Leukemia ◽  
Cytoplasmic Granules ◽  
Transmission Electron ◽  
Layer Membrane ◽  
Acute Myeloid

Pseudo Chediak-Higashi (PCH) granules are mainly common in acute myeloid leukemia. Here we found a patient diagnosed with common-B acute lymphoblastic leukemia(ALL) with PCH cytoplasmic granules, which was rarely seen in daily diagnosis. The morphology of the granules is different in transmission electron microscope (TEM) from cases reported before. There is a vesicle with various-sized particles surrounding the nucleus, in addition to the particles, a multiple-layer membrane structure was also detected in the vesicle.

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