scholarly journals Is it time to use hematopoietic stem cell transplantation for severe and refractory crohn's disease?

2020 ◽  
Vol 42 (2) ◽  
pp. 190-191 ◽  
Author(s):  
Milton Artur Ruiz ◽  
Roberto Luiz Kaiser Junior ◽  
Luiz Gustavo de Quadros
Keyword(s):  
Stem Cell ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Hematopoietic Stem

scholarly journals Medical, ethical, and legal aspects of hematopoietic stem cell transplantation for Crohn’s disease in Brazil

2020 ◽  
Vol 12 (10) ◽  
pp. 1113-1123
Author(s):  
Milton Artur Ruiz ◽  
Roberto Luiz Kaiser Junior ◽  
Lilian Piron-Ruiz ◽  
Priscila Samara Saran ◽  
Lilian Castiglioni ◽  
...  
Keyword(s):  
Stem Cell ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Legal Aspects ◽  
Hematopoietic Stem

Hematopoietic Stem Cell Transplantation an Alternative to Treat Crohn's Disease

2021 ◽  
pp. 498-508
Author(s):  
Milton Artur Ruiz ◽  
Montserrat Rovira ◽  
Elena Ricart ◽  
Roberto Luiz Kaiser ◽  
Richard K. Burt
Keyword(s):  
Stem Cell ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Hematopoietic Stem

Autologous Hematopoietic Stem Cell Transplantation in Patients with Severe and Refractory Crohn’s Disease.

Blood ◽  
2004 ◽  
Vol 104 (11) ◽  
pp. 1874-1874
Author(s):  
Yu Oyama ◽  
Robert M. Craig ◽  
Ann E. Traynor ◽  
Richard K. Burt ◽  
Laisvyde Statkute
Keyword(s):  
Stem Cell ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Sustained Remission ◽  
Hematopoietic Stem ◽  
Cell Counts

Abstract Background & Aims Crohn’s disease (CD) is an immunologically mediated inflammatory disease of the gastrointestinal tract. In theory, immune ablation followed by autologous hematopoietic stem cell transplantation (HSCT) can induce remission by reconstituting a new immune system. Methods We conducted a phase I HSCT study in 12 patients with severe CD. Candidates were less than 60 years old with a Crohn’s Disease Activity Index (CDAI) of 250–400 despite conventional therapy including infliximab. Peripheral blood stem cells were mobilized with cyclophosphamide and granulocyte colony-stimulating factor and CD34+ enriched. The immune ablative conditioning regimen consisted of 200mg/kg cyclophosphamide, and 90mg/kg equine antithymocyte globulin. Results The procedure was well tolerated with anticipated cytopenias, neutropenic fever, and disease-related fever, diarrhea, anorexia, nausea, vomiting. The median days for neutrophil and platelet engraftment were 9.5 (range 8–11) and 9 (range 9–18), respectively. The infused CD34+ and CD3+ cell counts were 5.64 x 106/kg (range 1.73–9.93) and 0.59 x 104/kg (range 0.3–3.09), respectively. Initial median CDAI was 291 (range 250–358). Symptoms and CDAI improved dramatically (figure 1), and radiographic and colonoscopy findings improved gradually over months to years following HSCT. Ten out of twelve patients entered sustained remission defined by a CDAI ≤ 100. After median follow-up of 17.5 months (range 6–37), only one patient has developed recurrence of active CD which occurred 15 months post-HSCT. Conclusion Autologous HSCT may be peformed safely and has a marked salutary effect on CD activity. Randomized studies will be needed to confirm the efficacy of this therapy. Figure Figure

Mo1176 Autologous Hematopoietic Stem Cell Transplantation in Refractory Crohn's Disease: Feasibility and Toxicity

2014 ◽  
Vol 146 (5) ◽  
pp. S-578
Author(s):  
Aranzazu Jauregui-Amezaga ◽  
Montserrat Rovira ◽  
Susana Pinó-Donnay ◽  
Pedro José Marín ◽  
Faust Feu ◽  
...  
Keyword(s):  
Stem Cell ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Hematopoietic Stem
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