scholarly journals Diffuse large B-cell lymphoma in blood and bone marrow: a rare presentation of leukemic phase at diagnosis

2020 ◽  
Vol 42 (2) ◽  
pp. 180-183
Author(s):  
Pooja K. Suresh ◽  
Sridevi Hanaganahalli Basavaiah ◽  
Mrigank Goel ◽  
Sanyo Dsouza ◽  
Santosh Rai
Keyword(s):  
Bone Marrow ◽  
B Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Rare Presentation ◽  
Large B Cell Lymphoma ◽  
Leukemic Phase ◽  
Large B Cell

SUBDIAPHRAGMATIC EXTRANODAL LOCALIZATIONS AT DIAGNOSIS OF PRIMARY MEDIASTINAL LARGE B-CELL LYMPHOMA: AN IMPRESSIVE, RARE PRESENTATION WITH NO INDEPENDENT EFFECT ON PROGNOSIS

2021 ◽  
pp. 106595
Author(s):  
Stamatis Karakatsanis ◽  
Sotirios G. Papageorgiou ◽  
Michail Michail ◽  
Maria K. Angelopoulou ◽  
Christina Kalpadakis ◽  
...  
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Independent Effect ◽  
Rare Presentation ◽  
Large B Cell Lymphoma ◽  
Large B Cell

scholarly journals Bone Marrow Molecular Markers Associated with Relapsed/Refractory Activated B-Cell-Like Diffuse Large B-Cell Lymphoma

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Di Wang ◽  
Peng Liu ◽  
Yue Zhang ◽  
Hui-Ying Liu ◽  
Di Shen ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Molecular Markers ◽  
B Cell ◽  
Bone Marrow Aspirate ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Significant Finding ◽  
Large B Cell Lymphoma ◽  
Significant Difference ◽  
Large B Cell

Activated B-cell-like diffuse large B-cell lymphoma (ABC-DLBCL) is a common subtype of non-Hodgkin’s lymphoma and is very likely to infiltrate the bone marrow. Over 30% of patients are converted to relapsed/refractory DLBCL after first-line rituximab combined with cyclophosphamide, doxorubicin, vincristine, and prednisone therapy, with a poor prognosis. Our aim was to identify molecular markers that might be utilized to predict relapsed/refractory ABC-DLBCL patients. Hence, we collected bone marrow aspirate smears from 202 patients with ABC-DLBCL and detected expression of bone marrow molecular marker proteins by immunocytochemistry. Signal transducer and activator of transcription (Stat)3, nuclear factor (NF)-κB p65, Syk, Bruton’s tyrosine kinase (BTK), and Bcl2 proteins were strongly expressed in bone marrow aspirate smears of ABC-DLBCL patients. The same smear could present positive expression of multiple proteins simultaneously. Positive combinations of protein expression were associated with resistance. The most significant finding was that the Stat3+NF-κB+ group developed resistance, which was significantly higher than that of the Stat3-NF-κB-group (80 vs. 14%). There was a significant difference in two-year relapse-free survival between protein-positive and protein-negative combinations of Stat3-NF-κB (P = 0.005), Bcl2-Stat3 (P = 0.009), Bcl2-Pax5 (P = 0.003), and BTK-Syk (P < 0.001). Thus, we detected key molecules in multiple signaling pathways in bone marrow aspirate smears. At the same time, the results provide further clinical evidence of ABC-DLBCL drug-resistant molecules and provide a theoretical basis for rational second-line treatment after drug resistance.

scholarly journals Diffuse large B-cell lymphoma of the vagina in pregnancy

2020 ◽  
Vol 13 (1) ◽  
pp. e233145
Author(s):  
Nwabundo Anusim ◽  
Filip Ionescu ◽  
Olabisi Afolayan-Oloye ◽  
Susanna S Gaikazian
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
Cardiac Activity ◽  
Pelvic Mass ◽  
B Cell Lymphoma ◽  
Whole Body ◽  
Rare Presentation ◽  
Whole Body Mri ◽  
Large B Cell Lymphoma ◽  
Large B Cell

A 28-year-old primigravida was evaluated for complaints of difficulty urinating and pelvic pain of 6-weeks duration. She denied fever, night sweats, weight loss or fatigue. Pelvic ultrasonography revealed a single fetal pole with cardiac activity and a 7 cm mass in the anterior vagina which encased the urethra. The diagnosis of diffuse large B-cell lymphoma germinal centre type was made on analysis of biopsied pelvic mass. Whole body MRI revealed the disease was limited to the vagina. The patient received six cycles of Rituximab-cyclophosphamide, doxorubicin, vincristine and prednisone with significant improvement in her symptoms. Serial ultrasounds over the subsequent months showed appropriate development of the fetus. Whole body MRI after treatment showed decreased size and decreased signal of the primary pelvic mass compatible with favourable treatment response. Challenges in the management of this rare presentation of lymphoma are discussed.

Hemophagocytic Syndrome in a Case of Splenic Large B-Cell Lymphoma

1996 ◽  
Vol 82 (6) ◽  
pp. 621-624 ◽  
Author(s):  
Gualtiero Büchi ◽  
Giuseppe Termine ◽  
Renzo Orlassino ◽  
Mauro Pagliarino ◽  
Roberto Boero ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Lymph Nodes ◽  
B Cell ◽  
Diagnostic Criteria ◽  
Hemophagocytic Syndrome ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Large B Cell Lymphoma ◽  
Peripheral Lymph ◽  
Large B Cell

A case of splenic large B-cell lymphoma with hemophagocytic syndrome is reported. The difficulties of diagnosis are emphasized especially when peripheral lymph nodes or bone marrow lymphomatous infiltration are not present. Diagnostic criteria for hemophagocytic syndrome and their relationship with the pathogenesis of the disease are also stressed.

Bone marrow large B cell lymphoma bearing cyclin D3 expression: clinical, morphologic, immunophenotypic, and genotypic analyses of seven patients

2009 ◽  
Vol 90 (2) ◽  
pp. 217-225 ◽  
Author(s):  
Jyuri Watanuki ◽  
Kinta Hatakeyama ◽  
Takashi Sonoki ◽  
Hiro Tatetsu ◽  
Katsuhiko Yoshida ◽  
...  
Keyword(s):  
Bone Marrow ◽  
B Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Cyclin D3 ◽  
Large B Cell Lymphoma ◽  
Large B Cell

Occult bone marrow involvement in patients with diffuse large B-cell lymphoma: results of a pilot study

Pathology ◽  
2007 ◽  
Vol 39 (6) ◽  
pp. 580-585 ◽  
Author(s):  
Dipti Talaulikar ◽  
Jane E. Dahlstrom ◽  
Bruce Shadbolt ◽  
Michelle McNiven ◽  
Amy Broomfield ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Pilot Study ◽  
B Cell ◽  
Cell Lymphoma ◽  
Bone Marrow Involvement ◽  
B Cell Lymphoma ◽  
Large B Cell Lymphoma ◽  
Large B Cell
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