scholarly journals Efficacy of combination therapy of hepatic arterial injection chemotherapy with radiotherapy for unresectable advanced hepatocellular carcinoma complicated by major vascular tumor thrombosis

HPB ◽  
2016 ◽  
Vol 18 ◽  
pp. e217-e218
Author(s):  
J. Tani ◽  
H. Miyoshi ◽  
T. Masaki
Keyword(s):  
Hepatocellular Carcinoma ◽  
Combination Therapy ◽  
Vascular Tumor ◽  
Advanced Hepatocellular Carcinoma ◽  
Tumor Thrombosis

Liver transplantation for hepatocellular carcinoma with portal vein tumor thrombosis

2021 ◽  
Vol 21 (2) ◽  
pp. 105-112
Author(s):  
Sang Jin Kim ◽  
Jong Man Kim
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Radiation Therapy ◽  
Portal Vein ◽  
Alpha Fetoprotein ◽  
Advanced Hepatocellular Carcinoma ◽  
Portal Vein Tumor Thrombosis ◽  
Donor Liver Transplantation ◽  
Tumor Thrombosis ◽  
Locoregional Therapies

Traditionally, liver transplantation for hepatocellular carcinoma with portal vein tumor thrombosis is not recommended. However, with recent developments in locoregional therapies for hepatocellular carcinoma, more aggressive treatments have been attempted for advanced hepatocellular carcinoma. Recently, various studies on locoregional therapies for downstaging followed by living donor liver transplantation reported inspiring overall survival and recurrence-free survival of patients. These downstaging procedures included three-dimensional conformal radiation therapy, trans-arterial chemoembolization, stereotactic body radiation therapy, trans-arterial radioembolization, hepatic arterial infusion chemotherapy and combinations of these therapies. Selection of the optimal downstaging protocol should depend on tumor location, biology and background liver status. The risk factors affecting outcome include pre-downstaging alpha-fetoprotein values, delta alpha-fetoprotein values, disappearance of portal vein tumor thrombosis on imaging and meeting the Milan criteria or not after downstaging. For hepatocellular carcinoma with portal vein tumor thrombosis, downstaging procedure with liver transplantation in mind would be helpful. If the reaction of the downstaged tumor is good, liver transplantation may be performed.

scholarly journals The Safety and Efficacy of Combination Therapy of Sorafenib and Radiotherapy for Advanced Hepatocellular Carcinoma: A Retrospective Study

2018 ◽  
Vol 57 (10) ◽  
pp. 1345-1353 ◽  
Author(s):  
Yoshiyuki Wada ◽  
Yuko Takami ◽  
Hajime Matsushima ◽  
Masaki Tateishi ◽  
Tomoki Ryu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Retrospective Study ◽  
Combination Therapy ◽  
Advanced Hepatocellular Carcinoma ◽  
Safety And Efficacy

Combination Therapy with S-1 and Pegylated Interferon Alpha for Advanced Hepatocellular Carcinoma

Oncology ◽  
2008 ◽  
Vol 75 (1) ◽  
pp. 106-113 ◽  
Author(s):  
Kazuomi Ueshima ◽  
Masatoshi Kudo ◽  
Tomoyuki Nagai ◽  
Chie Tatsumi ◽  
Taisuke Ueda ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Combination Therapy ◽  
Interferon Alpha ◽  
Pegylated Interferon ◽  
Advanced Hepatocellular Carcinoma ◽  
Pegylated Interferon Alpha
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