scholarly journals Dynamic evaluation of liver volume and function in associating liver partition and portal vein ligation for staged hepatectomy

HPB ◽  
2016 ◽  
Vol 18 ◽  
pp. e130
Author(s):  
E. Sparrelid ◽  
E. Jonas ◽  
A. Tzortzakakis ◽  
U. Dahlén ◽  
G. Murquist ◽  
...  
Keyword(s):  
Portal Vein ◽  
Liver Volume ◽  
Portal Vein Ligation ◽  
Dynamic Evaluation ◽  
And Function ◽  
Staged Hepatectomy

scholarly journals Dynamic Evaluation of Liver Volume and Function in Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy

2017 ◽  
Vol 21 (6) ◽  
pp. 967-974 ◽  
Author(s):  
Ernesto Sparrelid ◽  
Eduard Jonas ◽  
Antonios Tzortzakakis ◽  
Ulrika Dahlén ◽  
Gustav Murquist ◽  
...  
Keyword(s):  
Portal Vein ◽  
Liver Volume ◽  
Portal Vein Ligation ◽  
Dynamic Evaluation ◽  
And Function ◽  
Staged Hepatectomy

scholarly journals Preoperative Trans-catheter Arterial Chemoembolization and Laparoscopic Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy in Unresectable Hepatocellular Carcinoma – A Case Report

BioMedica ◽  
2021 ◽  
Vol 37 (2) ◽  
pp. 86-92
Author(s):  
Yilin Hu ◽  
Yanbing Shen ◽  
Dan Wang ◽  
Tingjia Cao
Keyword(s):  
Hepatocellular Carcinoma ◽  
Case Report ◽  
Portal Vein ◽  
Liver Volume ◽  
Postoperative Outcome ◽  
Portal Vein Ligation ◽  
The Right ◽  
Staged Hepatectomy ◽  
Arterial Chemoembolization

<p>Transcatheter arterial chemoembolization (TACE) is considered as a major method to treat hepatocellular carcinoma (HCC). Associated liver partition and portal vein ligation for staged hepatectomy (ALPPS) has been used to treat patients with advanced HCC. This case report documents the safety, efficacy, and feasibility of TACE and laparoscopic ALPPS to treat the unresectable HCC of the right liver with right intra-hepatic metastasis in a male patient. Percutaneous and trans-femoral artery TACE was performed preoperatively, and the ALPPS stage-I at the 4th week and stage-II after 14 days was carried out. Postoperative outcome was assessed after 180 days of follow-up. It is concluded that preoperative TACE and laparoscopic ALPPS offer a fine treatment alternative to the patients with insufficient residual liver volume and relatively-advanced and extensive HCC.</p>

scholarly journals Analyses of mitochondrial biogenesis and function after associating liver partition and portal vein ligation for staged hepatectomy (ALPPS)

HPB ◽  
2019 ◽  
Vol 21 ◽  
pp. S939-S940
Author(s):  
A. Fulop ◽  
A. Budai ◽  
Z. Radak ◽  
Z. Bori ◽  
E. Koltai ◽  
...  
Keyword(s):  
Portal Vein ◽  
Mitochondrial Biogenesis ◽  
Portal Vein Ligation ◽  
And Function ◽  
Staged Hepatectomy

scholarly journals Assessment of Liver Function Using 99mTc-Mebrofenin Hepatobiliary Scintigraphy in ALPPS (Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy)

2015 ◽  
Vol 9 (3) ◽  
pp. 353-360 ◽  
Author(s):  
Kasia P. Cieslak ◽  
Pim B. Olthof ◽  
Krijn P. van Lienden ◽  
Marc G. Besselink ◽  
Olivier R.C. Busch ◽  
...  
Keyword(s):  
Portal Vein ◽  
Liver Volume ◽  
Postoperative Liver Failure ◽  
Portal Vein Ligation ◽  
Hepatobiliary Scintigraphy ◽  
Remnant Liver ◽  
Total Liver Volume ◽  
Second Stage ◽  
Staged Hepatectomy

ALPPS (associating liver partition and portal vein ligation for staged hepatectomy) is a new surgical technique for patients in whom conventional treatment is not feasible due to insufficient future remnant liver (FRL). During the first stage of ALPPS, accelerated hypertrophy of the FRL is induced by ligation of the portal vein and in situ split of the liver. In the second stage, the deportalized liver is removed when the FRL volume has reached ≥25% of total liver volume. However, FRL volume does not necessarily reflect FRL function. 99mTc-mebrofenin hepatobiliary scintigraphy (HBS) with SPECT-CT is a quantitative test enabling regional assessment of parenchymal uptake function using a validated cut-off value for the prediction of postoperative liver failure (2.7%/min/m2). This paper describes the changes in FRL function and FRL volume in a 79-year-old patient diagnosed with metachronous colonic liver metastases who underwent ALPPS. We have observed a substantial difference between the increase in FRL volume and FRL function suggesting that HBS with SPECT-CT enables monitoring of the FRL function and could be a useful tool in the timing of resection in the second stage of the ALPPS procedure.

scholarly journals Case Report: Hepatic Artery Infusion Chemotherapy After Stage I ALPPS in a Patient With Huge HCC

2021 ◽  
Vol 8 ◽  
Author(s):  
Wenfeng Zhuo ◽  
Ang Li ◽  
Weibang Yang ◽  
Jinxin Duan ◽  
Jun Min ◽  
...  
Keyword(s):  
Portal Vein ◽  
Liver Volume ◽  
Future Liver Remnant ◽  
Stage I ◽  
Hepatic Artery Infusion ◽  
Portal Vein Ligation ◽  
Liver Remnant ◽  
Infusion Chemotherapy ◽  
Hepatic Artery Infusion Chemotherapy ◽  
Staged Hepatectomy

Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) can induce rapid hypertrophy of the liver remnant. However, with a background of liver cirrhosis or other chronic liver diseases, patients with a huge hepatocellular carcinoma (HCC) may sometimes face insufficiency of hepatocellular regeneration after associating liver partition and portal vein ligation for staged hepatectomy (ALPPS). Herein, we report a 56-year-old male with a vast HCC (13.3 × 8.5 × 13 cm) whose ratio of the future liver remnant (FLR)/standard liver volume (SLV) was 28.7% when the disease was first diagnosed. Inadequate hypertrophy of FLR was shown in postoperative volumetric assessment a month after stage I ALPPS. After multidisciplinary team discussion (MDT), the patient was decided to follow three courses of hepatic arterial infusion chemotherapy (HAIC) with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4). The last HAIC was performed together with transhepatic arterial embolization (TAE). Finally, ratio of the FLR/SLV increased from 28.7% to 40% during three-month intervals, meeting the requirements of the surgery. Stage II ALPPS, right trisectionectomy, was then successfully performed. There was no recurrence at half years of follow-up. In our case, HAIC seems to be more potent than transcatheter arterial chemoembolization (TACE) in maintaining the hyperplasia of the liver remnant, reducing tumor load, and preventing tumor progression in patients with a large HCC during ALPPS procedure. HAIC, following the first step of ALPPS, a pioneering treatment modality aiming for inadequate hypertrophy of FLR induced by ALPPS, could be an alternative procedure for patients with a vast HCC in clinical practice.

Rapid liver volume increase induced by associating liver partition with portal vein ligation for staged hepatectomy (ALPPS): Is it edema, steatosis, or true proliferation?

Surgery ◽  
2017 ◽  
Vol 161 (6) ◽  
pp. 1549-1552 ◽  
Author(s):  
Dilmurodjon Eshmuminov ◽  
Christoph Tschuor ◽  
Dimitri Aristotle Raptis ◽  
Andreas Boss ◽  
Moritz C. Wurnig ◽  
...  
Keyword(s):  
Portal Vein ◽  
Liver Volume ◽  
Portal Vein Ligation ◽  
Volume Increase ◽  
Staged Hepatectomy
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