scholarly journals Complication rate and five year survival after surgical resection for patients with a pancreatic neuroendocrine tumor; a systematic review

HPB ◽  
2016 ◽  
Vol 18 ◽  
pp. e766-e767
Author(s):  
A.P.J. Jilesen ◽  
C.H.J. van Eijck ◽  
S. van Dieren ◽  
D.J. Gouma ◽  
E.J.M. Nieveen van Dijkum
Keyword(s):  
Systematic Review ◽  
Neuroendocrine Tumor ◽  
Surgical Resection ◽  
Complication Rate ◽  
Pancreatic Neuroendocrine Tumor

scholarly journals A case of successful conversion from everolimus to surgical resection of a giant pancreatic neuroendocrine tumor

2017 ◽  
Vol 3 (1) ◽  
Author(s):  
Asahi Sato ◽  
Toshihiko Masui ◽  
Nao Sankoda ◽  
Kenzo Nakano ◽  
Yuichiro Uchida ◽  
...  
Keyword(s):  
Neuroendocrine Tumor ◽  
Surgical Resection ◽  
Pancreatic Neuroendocrine Tumor

Growth factor signaling in pancreatic neuroendocrine tumor metastases.

2019 ◽  
Vol 37 (4_suppl) ◽  
pp. 256-256
Author(s):  
Brenna Rheinheimer ◽  
Ronald Heimark ◽  
Tun Jie
Keyword(s):  
Liver Metastases ◽  
Neuroendocrine Tumor ◽  
Signaling Pathways ◽  
Surgical Resection ◽  
Metastatic Disease ◽  
Genetic Variants ◽  
Genomic Analysis ◽  
Pancreatic Neuroendocrine Tumor ◽  
Proliferation Index ◽  
Who Grade

256 Background: Pancreatic neuroendocrine tumors (PanNETs) are among one of the fastest growing cancer diagnoses, yet clinical management for patients with metastatic disease is largely empirically based. Currently, surgical resection remains the only curative option; however, surgical resection of metastatic disease may not be feasible. Preliminary genomic analysis of primary PanNETs revealed a complex mutational landscape with four common oncogenic events; but, critical activation pathways of metastatic lesions have yet to be elucidated. Therefore, pan-genomic analysis of metastatic PanNETs is necessary to understand which genes/pathways are deregulated in PanNET metastases for potential therapeutic exploitation. Methods: We initiated a preliminary genomic sequencing study to evaluate mutations in a set of matched primary and metastatic PanNETs to determine genetic variants involved in metastasis to the liver. De-identified FFPE tumor samples were analyzed from patients who underwent surgical resection without receiving preoperative therapy. DNA was isolated and whole exome sequencing was performed using the Nextera Rapid Capture Exome Kit by Illumina on an Illumina HiSeq 2000/2500. The following criteria were used to define genetic variants: bidirectional, non-synonymous, clean mapping in IGV, ≥ 15X coverage, and an alternate allele frequency of 0.3 ≤ x ≤ 0.7. Results: All metastatic PanNETs were classified as WHO grade G2/G3 based on their KI-67 proliferation index. Each primary PanNET contained an average of 102 genetic variants while liver metastases showed an average of 124 genetic variants. MUFFINN and string analysis revealed that primary PanNETs contained enrichment for mutations involved in the PI3K/Akt and Ras signaling pathways while liver metastases showed enrichment for mutations involved in the MAPK and ErbB signaling pathways. Additionally, two-thirds of liver metastases contained somatic mutations in FGFR3. Conclusions: We have discovered novel pathways that have the potential to regulate pancreatic neuroendocrine tumor metastasis along with an innovative signaling pathway that may sustain metastatic growth and survival as well as exploitation for therapeutic potential.

scholarly journals Surgical resection of primary tumor improves survival of pancreatic neuroendocrine tumor with liver metastases

Oncotarget ◽  
2017 ◽  
Vol 8 (45) ◽  
pp. 79785-79792 ◽  
Author(s):  
Lianyuan Tao ◽  
Dianrong Xiu ◽  
Abuduhaibaier Sadula ◽  
Chen Ye ◽  
Qing Chen ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Neuroendocrine Tumor ◽  
Surgical Resection ◽  
Primary Tumor ◽  
Pancreatic Neuroendocrine Tumor

Surgical Resection of Brainstem Cavernoma: A Systematic Review of the Literature

2020 ◽  
Author(s):  
Ryan Hess ◽  
Ahmad Kareem Almekkawi ◽  
Karl R. Abi-Aad ◽  
Rudy J. Rahme ◽  
Devi P. Patra ◽  
...  
Keyword(s):  
Systematic Review ◽  
Surgical Resection ◽  
Review Of The Literature ◽  
Brainstem Cavernoma
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