scholarly journals Comparison of the efficacy of percutaneous portal vein embolization (pve) prior to major liver resection and alpps (associating liver partition and portal vein ligation for staged hepatectomy), single center experience

HPB ◽  
2016 ◽  
Vol 18 ◽  
pp. e726
Author(s):  
O. Hahn ◽  
P. Pajor ◽  
I. Dudás ◽  
É. Török ◽  
A. Zsirka-Klein ◽  
...  
Keyword(s):  
Liver Resection ◽  
Portal Vein ◽  
Portal Vein Embolization ◽  
Portal Vein Ligation ◽  
Major Liver Resection ◽  
Single Center ◽  
Single Center Experience ◽  
Staged Hepatectomy

scholarly journals Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS): Preliminary results of a single center experience in Santiago, Chile

HPB ◽  
2016 ◽  
Vol 18 ◽  
pp. e239
Author(s):  
S.A. Uribe-Echevarría ◽  
M. Uribe M. ◽  
F. Riquelme M. ◽  
C. Mandiola B. ◽  
M.I. Zapata F. ◽  
...  
Keyword(s):  
Portal Vein ◽  
Portal Vein Ligation ◽  
Single Center ◽  
Preliminary Results ◽  
Single Center Experience ◽  
Staged Hepatectomy

Preoperative Portal Vein Embolization for Major Liver Resection

2008 ◽  
Vol 247 (1) ◽  
pp. 49-57 ◽  
Author(s):  
Adel Abulkhir ◽  
Paolo Limongelli ◽  
Andrew J. Healey ◽  
Osama Damrah ◽  
Paul Tait ◽  
...  
Keyword(s):  
Liver Resection ◽  
Portal Vein ◽  
Portal Vein Embolization ◽  
Major Liver Resection

Associating liver partition and portal vein ligation for staged hepatectomy versus portal vein embolization in staged hepatectomy for hepatocellular carcinoma: A randomized comparative study.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. 4578-4578
Author(s):  
Gang Huang
Keyword(s):  
Hepatocellular Carcinoma ◽  
Overall Survival ◽  
Portal Vein ◽  
Comparative Study ◽  
Risk Ratio ◽  
Portal Vein Embolization ◽  
Portal Vein Ligation ◽  
Liver Remnant ◽  
Staged Hepatectomy

4578 Background: Both Portal Vein Embolization (PVE) and Associating Liver Partition and Portal vein ligation for Staged hepatectomy (ALPPS) have been used in patients with unresectable hepatocellular carcinoma (HCC) due to insufficient volumes in future liver remnant (FLR). But it remains unclear for which thetapy has better long-term overall survival. Methods: This study was a single-center, prospective randomized comparative study. Patients were randomly assigned in a 1:1 ratio to the 2 groups. The primary endpoints was three-year overall survival rates. Results: Between November 2014 to June 2016, 76 patients with unresectable HCC due to inadequate volume of FLR were randomly assigned to ALPPS groups (n = 38) and PVE groups (n = 38). Thirty-seven patients (97.4%) in the ALPPS Group compared with 25 patients (65.8%) in the PVE Group were able to undergo staged hepatectomy (risk ratio 1.48, 95% CI 1.17-1.87, p < 0.001). The three-year overall survival (OS) rate of the ALPPS group (65.8%) (95% CI 50.7-80.9) was significantly better than the PVE Group (42.1%) (95% CI 26.4-57.8), (HR 0.50, 95% CI 0.26-0.98, two-sided p = 0.036). Major postoperative complications rates after the stage-2 hepatectomy were 54.1% in the ALPPS group and 20.0% in the PVE group ((risk ratio 2.70, 95% CI 1.17-6.25, p = 0.007). Conclusions: ALPPS resulted in significantly better long-term overall survival outcomes, at the expenses of a significantly higher perioperative morbidity rate compared with PVE in patients who had initially unresectable HCC. Clinical trial information: ChiCTR-IOC-14005646 .

scholarly journals Combined biembolization induces higher hypertrophy than portal vein embolization before major liver resection

HPB ◽  
2020 ◽  
Vol 22 (2) ◽  
pp. 298-305 ◽  
Author(s):  
Bertrand Le Roy ◽  
Arnaud Gallon ◽  
Francois Cauchy ◽  
Bruno Pereira ◽  
Johan Gagnière ◽  
...  
Keyword(s):  
Liver Resection ◽  
Portal Vein ◽  
Portal Vein Embolization ◽  
Major Liver Resection

scholarly journals Portal Vein Embolization is Associated with Reduced Liver Failure and Mortality in High-Risk Resections for Perihilar Cholangiocarcinoma

2020 ◽  
Vol 27 (7) ◽  
pp. 2311-2318 ◽  
Author(s):  
Pim B. Olthof ◽  
◽  
Luca Aldrighetti ◽  
Ruslan Alikhanov ◽  
Matteo Cescon ◽  
...  
Keyword(s):  
Liver Resection ◽  
Portal Vein ◽  
Liver Failure ◽  
Portal Vein Embolization ◽  
Future Liver Remnant ◽  
International Study ◽  
Perihilar Cholangiocarcinoma ◽  
Major Liver Resection ◽  
Biliary Leakage ◽  
Liver Remnant

Abstract Background Preoperative portal vein embolization (PVE) is frequently used to improve future liver remnant volume (FLRV) and to reduce the risk of liver failure after major liver resection. Objective This paper aimed to assess postoperative outcomes after PVE and resection for suspected perihilar cholangiocarcinoma (PHC) in an international, multicentric cohort. Methods Patients undergoing resection for suspected PHC across 20 centers worldwide, from the year 2000, were included. Liver failure, biliary leakage, and hemorrhage were classified according to the respective International Study Group of Liver Surgery criteria. Using propensity scoring, two equal cohorts were generated using matching parameters, i.e. age, sex, American Society of Anesthesiologists classification, jaundice, type of biliary drainage, baseline FLRV, resection type, and portal vein resection. Results A total of 1667 patients were treated for suspected PHC during the study period. In 298 patients who underwent preoperative PVE, the overall incidence of liver failure and 90-day mortality was 27% and 18%, respectively, as opposed to 14% and 12%, respectively, in patients without PVE (p < 0.001 and p = 0.005). After propensity score matching, 98 patients were enrolled in each cohort, resulting in similar baseline and operative characteristics. Liver failure was lower in the PVE group (8% vs. 36%, p < 0.001), as was biliary leakage (10% vs. 35%, p < 0.01), intra-abdominal abscesses (19% vs. 34%, p = 0.01), and 90-day mortality (7% vs. 18%, p = 0.03). Conclusion PVE before major liver resection for PHC is associated with a lower incidence of liver failure, biliary leakage, abscess formation, and mortality. These results demonstrate the importance of PVE as an integral component in the surgical treatment of PHC.

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