Galectin 3 is Markedly Elevated in Severe Heart Failure and Predicts Improvement in LV Volumes Post Cardiac Resynchronisation Therapy

2016 ◽  
Vol 25 ◽  
pp. S110
Author(s):  
S. Chua ◽  
C. Ajaero ◽  
B. Assadi-Khansari ◽  
J. Horowitz ◽  
A. Sverdlov ◽  
...  
Keyword(s):  
Heart Failure ◽  
Severe Heart Failure ◽  
Cardiac Resynchronisation Therapy ◽  
Cardiac Resynchronisation ◽  
Galectin 3 ◽  
Resynchronisation Therapy ◽  
Lv Volumes

scholarly journals Assessment of Cardiac Resynchronisation Therapy Efficacy Determining Factors for Patients with Moderate and Severe Heart Failure in the Population of Latvia in a 12 and 24 Month Study

2018 ◽  
Vol 72 (6) ◽  
pp. 313-321 ◽  
Author(s):  
Maija Vikmane ◽  
Oskars Kalējs ◽  
Ginta Kamzola ◽  
Dana Upīte ◽  
Madara Ventiņa ◽  
...  
Keyword(s):  
Heart Failure ◽  
Left Ventricle ◽  
Biventricular Pacing ◽  
Severe Heart Failure ◽  
Cardiac Resynchronisation Therapy ◽  
University Hospital ◽  
Device Implantation ◽  
Cardiac Resynchronisation ◽  
Resynchronisation Therapy ◽  
Qrs Morphology

Abstract The aim of this study was to evaluate treatment of patients with moderate and severe heart failure (HF) who were resistant to pharmacotherapy in Latvia and to assess the cardiac resynchronisation therapy (CRT) by exploring the predisposing factors which provides CRT efficacy. We accomplished prospective analysis of left ventricle ejection fraction (LVEF) and other parameter changes 12 and 24 months after CRT device implantation, dividing the population into two groups: responders — to whom LVEF improvement was ≥10% and non-responders where ≥ 10% LVEF improvement was not achieved. The study included 50 chronic HF patients with preserved sinus rhythm, who underwent CRT device implantation in Latvia at the Pauls Stradiņš Clinical University Hospital from June 2009 to March 2012. In the group of patients where 12 and 24 months after CRT device implantation LVEF improvement ≥10% was achieved, there were statistically significantly more patients with left bundle branch block (LBBB) QRS morphology, wider QRS complex, nonischemic genesis of HF, and normal systolic blood pressure. Patients with LVEF improvement had more pronounced ventricular dyssynchrony measured by Echo before CRT device implantation and, accordingly, the CRT mode was programmed as left ventricle paced before right ventricle and close to 100% biventricular pacing was achieved and the patient was female.

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