Estimation of In Vivo Human Myocardial Fibre Strain by Integrating Diffusion Tensor and Tagged MRI Using FE Modelling

2012 ◽  
Vol 21 (12) ◽  
pp. 864
Author(s):  
V.Y. Wang ◽  
C. Casta ◽  
P. Croisille ◽  
P. Clarysse ◽  
Y.-M. Zhu ◽  
...  
Keyword(s):  
Diffusion Tensor ◽  
Tagged Mri ◽  
Fe Modelling ◽  
Fibre Strain ◽  
Myocardial Fibre

Estimation of In Vivo Myocardial Fibre Strain Using an Architectural Atlas of the Human Heart

2013 ◽  
pp. 208-215 ◽  
Author(s):  
Christopher Casta ◽  
Vicky Y. Wang ◽  
Yue-Min Zhu ◽  
Brett R. Cowan ◽  
Pierre Croisille ◽  
...  
Keyword(s):  
Human Heart ◽  
Fibre Strain ◽  
Myocardial Fibre

In vivo diffusion tensor imaging of the neonatal rat brain development

2013 ◽  
Vol 44 (S 01) ◽  
Author(s):  
M Breu ◽  
D Reisinger ◽  
D Wu ◽  
Y Zhang ◽  
A Fatemi ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
Brain Development ◽  
Rat Brain ◽  
Diffusion Tensor ◽  
Neonatal Rat ◽  
Neonatal Rat Brain

scholarly journals Meyer’s Loop Anatomy Demonstrated Using Diffusion Tensor MR Imaging and Fiber Tractography at 3T

2014 ◽  
Vol 60 (5) ◽  
pp. 215-222 ◽  
Author(s):  
Cristina Goga ◽  
Zeynep Firat ◽  
Klara Brinzaniuc ◽  
Is Florian
Keyword(s):  
Diffusion Tensor Imaging ◽  
Diffusion Tensor ◽  
Region Of Interest ◽  
Fiber Tractography ◽  
Brain Images ◽  
3 Dimensional ◽  
Software Release ◽  
Magnetic Resonance Imaging Mri ◽  
Meyer’S Loop

Abstract Objective: The ultimate anatomy of the Meyer’s loop continues to elude us. Diffusion tensor imaging (DTI) and diffusion tensor tractography (DTT) may be able to demonstrate, in vivo, the anatomy of the complex network of white matter fibers surrounding the Meyer’s loop and the optic radiations. This study aims at exploring the anatomy of the Meyer’s loop by using DTI and fiber tractography. Methods: Ten healthy subjects underwent magnetic resonance imaging (MRI) with DTI at 3 T. Using a region-of-interest (ROI) based diffusion tensor imaging and fiber tracking software (Release 2.6, Achieva, Philips), sequential ROI were placed to reconstruct visual fibers and neighboring projection fibers involved in the formation of Meyer’s loop. The 3-dimensional (3D) reconstructed fibers were visualized by superimposition on 3-planar MRI brain images to enhance their precise anatomical localization and relationship with other anatomical structures. Results: Several projection fiber including the optic radiation, occipitopontine/parietopontine fibers and posterior thalamic peduncle participated in the formation of Meyer’s loop. Two patterns of angulation of the Meyer’s loop were found. Conclusions: DTI with DTT provides a complimentary, in vivo, method to study the details of the anatomy of the Meyer’s loop.

The effect of microvascular obstruction on the myocardial microstructure: a diffusion tensor imaging study

2021 ◽  
Vol 22 (Supplement_1) ◽  
Author(s):  
A Das ◽  
K Kelly ◽  
M Aldred ◽  
I Teh ◽  
CK Stoeck ◽  
...  
Keyword(s):  
Microvascular Obstruction ◽  
Diffusion Tensor ◽  
Spin Echo ◽  
Mean Diffusivity ◽  
Imaging Study ◽  
Free Breathing ◽  
Helix Angle ◽  
Acquisition Time ◽  
Heart Research

Abstract Funding Acknowledgements Type of funding sources: Foundation. Main funding source(s): Heart Research UK Background Diffusion tensor cardiac magnetic resonance (DT-CMR) imaging allows for characterising myocardial microstructure in-vivo using mean diffusivity (MD), fractional anisotropy (FA), secondary eigenvector angle (E2A) and helix angle (HA) maps. Following myocardial infarction (MI), alterations in MD, FA and HA proportions have previously been reported. E2A depicts the contractile state of myocardial sheetlets, however the behaviour of E2A in infarct segments, and all DTI markers in areas of microvascular obstruction (MVO) is also not fully understood.  Purpose We performed spin echo DTI in patients following ST-elevation MI (STEMI) in order to investigate acute changes in DTI parameters in remote and infarct segments both with and without MVO. Method Twenty STEMI patients (16 men, 4 women, mean age 59) had acute (5 ± 2d) 3T CMR scans. CMR protocol included: second order motion compensated (M012) free-breathing spin echo DTI (3 slices, 18 diffusion directions at b-values 100s/mm2[3], 200s/mm2[3] and 500s/mm2[12], reconstructed resolution was 1.66x1.66x8mm); cine and late gadolinium enhancement (LGE) imaging. Average MD, FA, E2A HA parameters were calculated on a  16 AHA segmental level. HA maps were described by dividing values into left-handed HA (LHM, -90° < HA < -30°), circumferential HA (CM, -30° < HA < 30°), and right-handed HA (RHM, 30° < HA < 90°) and reported as relative proportions. Segments were defined as infarct (positive for LGE) and remote (opposite to the infarct).  Results DTI acquisition was successful in all patients (acquisition time 13 ± 5mins). Ten patients had evidence of MVO on LGE images. MD was significantly higher in infarct regions in comparison to remote; MVO-ve infarct segments had significantly higher MD than MVO + ve infarct segments (MD remote= 1.46 ± 0.12x10-3mm2/s, MD MVO + ve = 1.59 ± 0.12x10-3mm2/s, MD MVO-ve  = 1.75 ± 0.12x10-3mm2/s, ANOVA p < 0.01). FA was reduced in infarct segments in comparison to remote; MVO-ve infarct segments had significantly lower FA than MVO + ve infarct segments (FAremote= 0.37 ± 0.02, FA MVO + ve = 0.31 ± 0.02 x 10-3mm2/s, MD MVO-ve =0.25 ± 0.02, ANOVA p < 0.01). E2A values were significantly lower in infarct segments compared to remote; MVO + ve infarct segments had significantly lower values than MVO-ve. (E2A remote= 57.4 ± 5.2°, E2A MVO-ve = 46.8 ± 2.5°, E2A MVO + ve = 36.8 ± 3.1°, ANOVA p < 0.001). RHM% (corresponding to subendocardium) was significantly lower in infarct segments compared to remote; MVO + ve infarct segments had significantly lower RHM% than MVO-ve. (RHM remote= 37 ± 3%, RHM RHM MVO-ve= 28 ± 7%, MVO + ve= 8 ± 5%, ANOVA p < 0.001). Conclusion The presence of MVO results in a decrease in MD and increase in FA in comparison to surrounding infarct segments. However, the reduction in E2A and right-handed myocytes on HA in infarct segments is further exacerbated by the presence of MVO. Further study is required to investigate the underlying mechanisms for such alterations in signal intensity. Abstract Figure. A case of transmural septal MI with MVO

scholarly journals Thalamic Connectivity in Patients with Essential Tremor Treated with MR Imaging–guided Focused Ultrasound: In Vivo Fiber Tracking by Using Diffusion-Tensor MR Imaging

Radiology ◽  
2014 ◽  
Vol 272 (1) ◽  
pp. 202-209 ◽  
Author(s):  
Max Wintermark ◽  
Diane S. Huss ◽  
Binit B. Shah ◽  
Nicholas Tustison ◽  
T. Jason Druzgal ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Essential Tremor ◽  
Focused Ultrasound ◽  
Diffusion Tensor ◽  
Fiber Tracking ◽  
Diffusion Tensor Mr Imaging

scholarly journals Increased extracellular fluid is associated with white matter fiber degeneration in CADASIL: in vivo evidence from diffusion magnetic resonance imaging

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Xinfeng Yu ◽  
Xinzhen Yin ◽  
Hui Hong ◽  
Shuyue Wang ◽  
Yeerfan Jiaerken ◽  
...  
Keyword(s):  
White Matter ◽  
Diffusion Tensor ◽  
Small Vessel Disease ◽  
Extracellular Fluid ◽  
Free Water ◽  
Inverse Correlation ◽  
Brain Regions ◽  
Fiber Density ◽  
Four Levels

Abstract Background White matter hyperintensities (WMHs) are one of the hallmarks of cerebral small vessel disease (CSVD), but the pathological mechanisms underlying WMHs remain unclear. Recent studies suggest that extracellular fluid (ECF) is increased in brain regions with WMHs. It has been hypothesized that ECF accumulation may have detrimental effects on white matter microstructure. To test this hypothesis, we used cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) as a unique CSVD model to investigate the relationships between ECF and fiber microstructural changes in WMHs. Methods Thirty-eight CADASIL patients underwent 3.0 T MRI with multi-model sequences. Parameters of free water (FW) and apparent fiber density (AFD) obtained from diffusion-weighted imaging (b = 0 and 1000 s/mm2) were respectively used to quantify the ECF and fiber density. WMHs were split into four subregions with four levels of FW using quartiles (FWq1 to FWq4) for each participant. We analyzed the relationships between FW and AFD in each subregion of WMHs. Additionally, we tested whether FW of WMHs were associated with other accompanied CSVD imaging markers including lacunes and microbleeds. Results We found an inverse correlation between FW and AFD in WMHs. Subregions of WMHs with high-level of FW (FWq3 and FWq4) were accompanied with decreased AFD and with changes in FW-corrected diffusion tensor imaging parameters. Furthermore, FW was also independently associated with lacunes and microbleeds. Conclusions Our study demonstrated that increased ECF was associated with WM degeneration and the occurrence of lacunes and microbleeds, providing important new insights into the role of ECF in CADASIL pathology. Improving ECF drainage might become a therapeutic strategy in future.

scholarly journals Insights into the Connectivity of the Human Brain Using DTI

2012 ◽  
Vol 1 (1) ◽  
pp. 78-91 ◽  
Author(s):  
S Kollias
Keyword(s):  
Human Brain ◽  
Molecular Diffusion ◽  
Diffusion Tensor ◽  
Wide Spectrum ◽  
Diffusion Imaging ◽  
Structural Connectivity ◽  
Nerve Tissue ◽  
Mammalian Brain ◽  
Fibre Direction

Diffusion tensor imaging (DTI) is a neuroimaging MR technique, which allows in vivo and non-destructive visualization of myeloarchitectonics in the neural tissue and provides quantitative estimates of WM integrity by measuring molecular diffusion. It is based on the phenomenon of diffusion anisotropy in the nerve tissue, in that water molecules diffuse faster along the neural fibre direction and slower in the fibre-transverse direction. On the basis of their topographic location, trajectory, and areas that interconnect the various fibre systems of the mammalian brain are divided into commissural, projectional and association fibre systems. DTI has opened an entirely new window on the white matter anatomy with both clinical and scientific applications. Its utility is found in both the localization and the quantitative assessment of specific neuronal pathways. The potential of this technique to address connectivity in the human brain is not without a few methodological limitations. A wide spectrum of diffusion imaging paradigms and computational tractography algorithms has been explored in recent years, which established DTI as promising new avenue, for the non-invasive in vivo mapping of structural connectivity at the macroscale level. Further improvements in the spatial resolution of DTI may allow this technique to be applied in the near future for mapping connectivity also at the mesoscale level. DOI: http://dx.doi.org/10.3126/njr.v1i1.6330 Nepalese Journal of Radiology Vol.1(1): 78-91

In vivo isotropic 3D diffusion tensor mapping of the rat brain using diffusion-weighted 3D MP-RAGE MRI

2006 ◽  
Vol 24 (3) ◽  
pp. 287-293 ◽  
Author(s):  
Tomokazu Numano ◽  
Kazuhiro Homma ◽  
Nobuaki Iwasaki ◽  
Koji Hyodo ◽  
Naotaka Nitta ◽  
...  
Keyword(s):  
Rat Brain ◽  
Diffusion Tensor ◽  
Diffusion Weighted
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