Fast Track Recovery Following En Bloc Heart–Lung–Liver Transplantation in a Patient with Cystic Fibrosis Complicated by Severe Portal Hypertension

2008 ◽  
Vol 17 (2) ◽  
pp. 154-156 ◽  
Author(s):  
Igor E. Konstantinov ◽  
Keith McNeil ◽  
Shinn Yeung ◽  
Jonathan Fawcett ◽  
Daniel Mullany ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Liver Transplantation ◽  
Portal Hypertension ◽  
Fast Track ◽  
En Bloc ◽  
Fast Track Recovery

scholarly journals Liver Transplantation for Cirrhosis in Cystic Fibrosis

2006 ◽  
Vol 20 (7) ◽  
pp. 475-478 ◽  
Author(s):  
T Lamireau ◽  
S Martin ◽  
M Lallier ◽  
JE Marcotte ◽  
F Alvarez
Keyword(s):  
Cystic Fibrosis ◽  
Liver Transplantation ◽  
Portal Hypertension ◽  
Pulmonary Function ◽  
Hepatic Failure ◽  
Hepatic Transplantation ◽  
Significant Deterioration ◽  
Postoperative Course ◽  
The Third ◽  
Cystic Fibrosis Population

BACKGROUND: Liver disease is the third most common cause of death in children with cystic fibrosis (CF). Liver transplantation is an effective treatment in children with hepatic failure.AIMS: The objective of the present study was to review the indications and postoperative course of hepatic transplantation in a cystic fibrosis population.PATIENTS: Five children with CF, at a mean age of 16.5 years, underwent liver transplantation.RESULTS: All patients showed cirrhosis, portal hypertension and hepatic failure. The main postoperative complication was ascites refractory to treatment in two patients. No significant deterioration of the pulmonary function was noted. Two patients died, one of Hodgkin lymphoma and the other of progressive pulmonary failure.CONCLUSION: Liver transplantation was indicated in children with CF when hepatic failure and/or severe portal hypertension was present with well-preserved pulmonary function.

Liver Transplantation in Children with Cystic Fibrosis: Experience in our Centre and Preliminary Results with a Combined En Bloc Liver-Pancreas Graft

2011 ◽  
Vol 22 (01) ◽  
pp. 060-066 ◽  
Author(s):  
M. Miguel ◽  
A.M. Andres ◽  
M. Lopez-Santamaria ◽  
S. Barrena ◽  
L. Hierro ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Liver Transplantation ◽  
En Bloc ◽  
Preliminary Results ◽  
Pancreas Graft

EN BLOC HEART–LUNG–LIVER TRANSPLANTATION IN PATIENTS WITH END-STAGE CYSTIC FIBROSIS

2007 ◽  
Vol 16 ◽  
pp. S42-S43
Author(s):  
Igor E. Konstantinov ◽  
Sumit Yadav ◽  
Keith McNeil ◽  
Shinn Yeung ◽  
Jonathan Fawcett ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Liver Transplantation ◽  
En Bloc ◽  
End Stage

4 year outcome of combined 'en bloc' liver-pancreas transplant in two adolescents with cystic fibrosis

2015 ◽  
Author(s):  
Moira Cheung ◽  
Fiona Bartlett ◽  
Hilary Wyatt ◽  
Charles Buchanan ◽  
Ritika Kapoor
Keyword(s):  
Cystic Fibrosis ◽  
Pancreas Transplant ◽  
En Bloc

Cirrhosis and Complications of Portal Hypertension

2018 ◽  
Author(s):  
Andres Cardenas ◽  
Isabel Graupera ◽  
Elsa Sola ◽  
Pere Ginès
Keyword(s):  
Liver Transplantation ◽  
Portal Hypertension ◽  
Variceal Bleeding ◽  
Bacterial Infections ◽  
Hepatorenal Syndrome ◽  
Wide Spectrum ◽  
Clinical Manifestations ◽  
Diagnostic Methods ◽  
Decompensated Cirrhosis ◽  
Ultrasound Images

Cirrhosis is the most advanced stage of all the different types of chronic liver diseases. It is defined as a diffuse disorganization of normal hepatic structure by extensive fibrosis associated with regenerative nodules. Hepatic fibrosis is potentially reversible if the causative agent is removed. However, advanced cirrhosis leads to major alterations in the hepatic vascular bed and is usually irreversible. Cirrhosis is a progressive and severe clinical condition associated with considerable morbidity and high mortality. It leads to a wide spectrum of characteristic clinical manifestations, mainly attributable to hepatic insufficiency and portal hypertension. Major complications of portal hypertension include ascites, gastrointestinal (GI) variceal bleeding, hepatic encephalopathy (HE), renal failure, and bacterial infections. In recent years, major advances in the understanding of the natural history and pathophysiology of cirrhosis and the treatment of its complications have led to improved management, quality of life, and life expectancy of patients with this disease. Cirrhosis is also a risk factor for developing hepatocellular carcinoma (HCC). Decompensated cirrhosis carries a poor short-term prognosis; thus, orthotopic liver transplantation (OLT) should always be considered in suitable candidates. This chapter describes the epidemiology, etiology and genetic factors, pathogenesis, diagnosis, general management, and treatment of cirrhosis. Complications of cirrhosis are discussed, including ascites, spontaneous bacterial peritonitis, dilutional hyponatremia, hepatorenal syndrome, variceal bleeding, hepatopulmonary syndrome and postpulmonary hypertension, HE, and HCC. Indications and contraindications for liver transplantation are described. Figures show liver biopsy results and ultrasound images in cirrhosis from hepatitis C, a patient with tense ascites, transjugular intrahepatic portosystemic shunting (TIPS), large esophageal varices with red spots, and HCC. Tables outline the main causes of cirrhosis and the diagnostic methods for identifying them, the Child-Pugh score, diagnostic criteria for hepatorenal syndrome, grades of HE, and indications for liver transplantation.This chapter contains 6 highly rendered figures, 8 tables, 73 references.

Sign in / Sign up

Export Citation Format

Share Document