Conduct of Clinical Trials in Acute Heart Failure: Regional Differences in Heart Failure Clinical Trials

2011 ◽  
Vol 7 (4) ◽  
pp. 539-544 ◽  
Author(s):  
Mona Fiuzat ◽  
Robert M. Califf
Keyword(s):  
Heart Failure ◽  
Clinical Trials ◽  
Acute Heart Failure ◽  
Regional Differences

scholarly journals Clinical Trials of Pharmacological Therapies in Acute Heart Failure Syndromes

2010 ◽  
Vol 3 (2) ◽  
pp. 314-325 ◽  
Author(s):  
G. Michael Felker ◽  
Peter S. Pang ◽  
Kirkwood F. Adams ◽  
John G.F. Cleland ◽  
Gad Cotter ◽  
...  
Keyword(s):  
Heart Failure ◽  
Clinical Trials ◽  
Acute Heart Failure ◽  
Acute Heart Failure Syndromes

scholarly journals End Points for Clinical Trials in Acute Heart Failure Syndromes

2009 ◽  
Vol 53 (24) ◽  
pp. 2248-2258 ◽  
Author(s):  
Larry A. Allen ◽  
Adrian F. Hernandez ◽  
Christopher M. O'Connor ◽  
G. Michael Felker
Keyword(s):  
Heart Failure ◽  
Clinical Trials ◽  
Acute Heart Failure ◽  
End Points ◽  
Acute Heart Failure Syndromes

scholarly journals A proposal to standardize dyspnoea measurement in clinical trials of acute heart failure syndromes: the need for a uniform approach

2008 ◽  
Vol 29 (6) ◽  
pp. 816-824 ◽  
Author(s):  
P. S. Pang ◽  
J. G.F. Cleland ◽  
J. R. Teerlink ◽  
S. P. Collins ◽  
C. J. Lindsell ◽  
...  
Keyword(s):  
Heart Failure ◽  
Clinical Trials ◽  
Acute Heart Failure ◽  
Uniform Approach ◽  
Acute Heart Failure Syndromes

How to measure dyspnea in acute heart failure?

2009 ◽  
Vol 66 (9) ◽  
pp. 639-642 ◽  
Author(s):  
Thenral Socrates ◽  
Alexandre Mebazaa
Keyword(s):  
Heart Failure ◽  
Clinical Trials ◽  
Clinical Practice ◽  
Acute Heart Failure ◽  
Analogue Scale ◽  
Time Course ◽  
Sitting Position ◽  
Point Scale ◽  
Course Of Disease ◽  
Important Target

Dyspnea is the most common presenting symptom of patients with acute heart failure (AHF). Although dyspnea is an important target for treatment in clinical practice and clinical trials, there remains a lack of consensus on how to assess it. We describe and recommend to use absolute scales such the Likert 5-point or the Visual Analogue Scale rather than any comparator scale such as the Likert 7-point scale. We further recommend starting dyspnea measurements in sitting position and perform, if possible, similar measurements in lying position. The same set of measurements may be repeated as needed during the time course of disease and the treatment.

scholarly journals Improvement of Cardiac Vegetations in Antiphospholipid Syndrome with Enoxaparin and Corticosteroids after Rivaroxaban Failure

2018 ◽  
Vol 2018 ◽  
pp. 1-4
Author(s):  
Eric Granowicz ◽  
Kiyon Chung
Keyword(s):  
Heart Failure ◽  
Clinical Trials ◽  
Autoimmune Disease ◽  
Acute Heart Failure ◽  
Antiphospholipid Syndrome ◽  
Steroid Therapy ◽  
Cardiac Disease ◽  
Marked Improvement ◽  
Cardiac Involvement

Cardiac disease is a well-known complication of antiphospholipid syndrome (APS), with many patients presenting with valvular thickening or vegetations, referred to as Libman–Sacks endocarditis (LSE). Because cases of APS with cardiac involvement are relatively rare, paucity of large clinical trials studying this complication has made management challenging. In the absence of acute heart failure and embolic events, a medical approach is usually selected, consisting of anticoagulation and possibly corticosteroids when another underlying autoimmune disease is present. However, the role of various anticoagulant classes and the duration of steroid therapy continue to be debated. Here, we present a 45-year-old woman who developed two vegetations in the setting of secondary APS while taking rivaroxaban before experiencing marked improvement with the use of enoxaparin and steroids.

A Critical Appraisal of Short-Term End Points in Acute Heart Failure Clinical Trials

2018 ◽  
Vol 24 (11) ◽  
pp. 783-792 ◽  
Author(s):  
Carine E. Hamo ◽  
Christopher O'Connor ◽  
Marco Metra ◽  
James E. Udelson ◽  
Mihai Gheorghiade ◽  
...  
Keyword(s):  
Heart Failure ◽  
Clinical Trials ◽  
Acute Heart Failure ◽  
Critical Appraisal ◽  
Short Term ◽  
End Points

Natriuretic peptides for the treatment of acute heart failure: a focus on nesiritide in recent clinical trials

2015 ◽  
Vol 13 (7) ◽  
pp. 743-751 ◽  
Author(s):  
Jeff Fajardo ◽  
J Thomas Heywood ◽  
J Herbert Patterson ◽  
Kirkwood Adams ◽  
Sheryl L Chow
Keyword(s):  
Heart Failure ◽  
Clinical Trials ◽  
Acute Heart Failure ◽  
Natriuretic Peptides
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