scholarly journals T Cell Repertoire Diversity Is Decreased in Type 1 Diabetes Patients

2016 ◽  
Vol 14 (6) ◽  
pp. 338-348 ◽  
Author(s):  
Yin Tong ◽  
Zhoufang Li ◽  
Hua Zhang ◽  
Ligang Xia ◽  
Meng Zhang ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
T Cell Repertoire ◽  
Cell Repertoire ◽  
Repertoire Diversity ◽  
Diabetes Patients

scholarly journals Genetic-induced Variations in the GAD65 T-cell Repertoire Governs Efficacy of Anti-CD3/GAD65 Combination Therapy in New-onset Type 1 Diabetes

2010 ◽  
Vol 18 (2) ◽  
pp. 307-316 ◽  
Author(s):  
Damien Bresson ◽  
Matthew Fradkin ◽  
Yulia Manenkova ◽  
Diane Rottembourg ◽  
Matthias von Herrath
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
Combination Therapy ◽  
T Cell Repertoire ◽  
Cell Repertoire ◽  
Onset Type ◽  
New Onset

scholarly journals Characterization of human cytomegalovirus peptide–specific CD8+ T-cell repertoire diversity following in vitro restimulation by antigen-pulsed dendritic cells

Blood ◽  
2002 ◽  
Vol 99 (1) ◽  
pp. 213-223 ◽  
Author(s):  
Karl Peggs ◽  
Stephanie Verfuerth ◽  
Arnold Pizzey ◽  
Jenni Ainsworth ◽  
Paul Moss ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
T Cell ◽  
Viral Replication ◽  
Cd8 T Cells ◽  
Cd8 T Cell ◽  
T Cell Repertoire ◽  
Cell Repertoire ◽  
Repertoire Diversity ◽  
Clonal Composition

Under conditions of impaired T-cell immunity, human cytomegalovirus (HCMV) can reactivate from lifelong latency, resulting in potentially fatal disease. A crucial role for CD8+ T cells has been demonstrated in control of viral replication, and high levels of HCMV-specific cytotoxic T-lymphocytes are seen in immunocompetent HCMV-seropositive individuals despite very low viral loads. Elucidation of the minimum portion of the anti-HCMV T-cell repertoire that is required to suppress viral replication requires further study of clonal composition. The ability of dendritic cells to take up and process exogenous viral antigen by constitutive macropinocytosis was used to study HCMV-specific T-cell memory in the absence of viral replication. The specificity and clonal composition of the CD8+ T-cell responses were evaluated using HLA tetrameric complexes and T-cell receptor β chain (TCRBV) spectratypic analyses. There was a skewed reactivity toward the matrix protein pp65, with up to 40-fold expansion of CD8+ T cells directed toward a single peptide-MHC combination. Individual expansions detected on TCRBV spectratype analysis were HCMV-specific and composed of single or highly restricted numbers of clones. There was preferential TCRBV gene usage (BV6.1/6.2, BV8, and BV13 in HLA-A*0201+ individuals) but lack of conservation of CDR3 length and junctional motifs between donors. While there was a spectrum of TCR repertoire diversity directed toward individual MHC-peptide combinations between donors, a relatively small number of clones appeared to predominate the response in each case. These data provide further insight into the range of anti-HCMV responses and will aid the design and monitoring of adoptive immunotherapy protocols.

scholarly journals Cytomegalovirus Exposure in the Elderly Does Not Reduce CD8 T Cell Repertoire Diversity

2018 ◽  
Vol 202 (2) ◽  
pp. 476-483 ◽  
Author(s):  
Paul Lindau ◽  
Rithun Mukherjee ◽  
Miriam V. Gutschow ◽  
Marissa Vignali ◽  
Edus H. Warren ◽  
...  
Keyword(s):  
T Cell ◽  
The Elderly ◽  
Cd8 T Cell ◽  
T Cell Repertoire ◽  
Cell Repertoire ◽  
Repertoire Diversity

scholarly journals Altered T-cell repertoire diversity in septic shock patients

Critical Care ◽  
2014 ◽  
Vol 18 (Suppl 1) ◽  
pp. P223
Author(s):  
N Takeyama ◽  
A Tomino ◽  
M Hashiba ◽  
A Hirakawa ◽  
T Hattori ◽  
...  
Keyword(s):  
Septic Shock ◽  
T Cell ◽  
T Cell Repertoire ◽  
Cell Repertoire ◽  
Repertoire Diversity

T-cell repertoire diversity and clonal expansions in normal and clinical samples

1995 ◽  
Vol 16 (4) ◽  
pp. 176-181 ◽  
Author(s):  
Christophe Pannetier ◽  
Jos Even ◽  
Philippe Kourilsky
Keyword(s):  
T Cell ◽  
Clinical Samples ◽  
T Cell Repertoire ◽  
Cell Repertoire ◽  
Repertoire Diversity

scholarly journals Dacarbazine Treatment before Peptide Vaccination Enlarges T-Cell Repertoire Diversity of Melan-A–Specific, Tumor-Reactive CTL in Melanoma Patients

2010 ◽  
Vol 70 (18) ◽  
pp. 7084-7092 ◽  
Author(s):  
Belinda Palermo ◽  
Duilia Del Bello ◽  
Alessandra Sottini ◽  
Federico Serana ◽  
Claudia Ghidini ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Repertoire ◽  
Peptide Vaccination ◽  
Cell Repertoire ◽  
Specific Tumor ◽  
Repertoire Diversity ◽  
Melanoma Patients

scholarly journals Impact of T Cell Repertoire Diversity on Mortality Following Cord Blood Transplantation

2020 ◽  
Vol 10 ◽  
Author(s):  
F. Milano ◽  
R. O. Emerson ◽  
R. Salit ◽  
K. A. Guthrie ◽  
L. A. Thur ◽  
...  
Keyword(s):  
T Cell ◽  
Cord Blood ◽  
Cord Blood Transplantation ◽  
T Cell Repertoire ◽  
Cell Repertoire ◽  
Blood Transplantation ◽  
Repertoire Diversity
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