Vitamin D receptor gene methylation in hepatocellular carcinoma

Gene ◽  
2018 ◽  
Vol 653 ◽  
pp. 65-71 ◽  
Author(s):  
Mai Abdalla ◽  
Eman Khairy ◽  
Manal L. Louka ◽  
Randa Ali-Labib ◽  
Eman Abdel-Salam Ibrahim
Keyword(s):  
Hepatocellular Carcinoma ◽  
Vitamin D ◽  
Vitamin D Receptor ◽  
Receptor Gene ◽  
Vitamin D Receptor Gene ◽  
Gene Methylation

Study of vitamin D receptor gene methylation and the risk of gestational diabetes mellitus in Iranian pregnant women

Gene Reports ◽  
2021 ◽  
Vol 22 ◽  
pp. 100978
Author(s):  
Pooneh Mokarram ◽  
Golzar Rahmannezhad ◽  
Mehran Erfani ◽  
Mohammad Reza Rezvanfar ◽  
Farideh Jalali Mashayekhi
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Vitamin D Receptor ◽  
Receptor Gene ◽  
Vitamin D Receptor Gene ◽  
Gene Methylation

scholarly journals Vitamin D receptor gene methylation is associated with ethnicity, tuberculosis, and TaqI polymorphism

2011 ◽  
Vol 72 (3) ◽  
pp. 262-268 ◽  
Author(s):  
Charlene Andraos ◽  
Gerrit Koorsen ◽  
Julian C. Knight ◽  
Liza Bornman
Keyword(s):  
Vitamin D ◽  
Vitamin D Receptor ◽  
Receptor Gene ◽  
Vitamin D Receptor Gene ◽  
Gene Methylation ◽  
Taqi Polymorphism

Vitamin D receptor gene methylation in patients with hand, foot, and mouth disease caused by enterovirus 71

2020 ◽  
Vol 165 (9) ◽  
pp. 1979-1985
Author(s):  
Ya-Ping Li ◽  
Hui-Ling Deng ◽  
Wen-Jun Wang ◽  
Mu-Qi Wang ◽  
Mei Li ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Receptor ◽  
Receptor Gene ◽  
Enterovirus 71 ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Vitamin D Receptor Gene ◽  
Gene Methylation ◽  
Foot And Mouth

scholarly journals Vitamin D Receptor Gene Polymorphisms and the Risk of Chronic Hepatitis C Related Hepatocellular Carcinoma in Egyptian Population

2021 ◽  
Vol 11 (1) ◽  
pp. 79-85
Author(s):  
Amal A. Mohamed ◽  
Sherief Abd-Elsalam ◽  
Hanan M. Mostafa ◽  
Asmaa Abdalla ◽  
Ahmed Farouk ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Vitamin D ◽  
Liver Cirrhosis ◽  
Hepatitis C ◽  
Vitamin D Receptor ◽  
Gene Polymorphisms ◽  
Receptor Gene ◽  
Stepwise Logistic Regression ◽  
Vitamin D Receptor Gene ◽  
Egyptian Patients

Background: Small percentage of hepatitis C (HCV) patients develop hepatocellular carcinoma (HCC) during their lifetime, suggesting that genetic factors might modulate HCC development. Numerous variations on the vitamin D receptor gene (VDR) have been recognized in human cancers. The majority of them cause VDR to be unable to bind to 1, 25-OH-D. The aim of the present work was to investigate the relation of VDR FokI (rs2228570), BsmI (rs3782905) and ApaI (rs7975232) gene polymorphisms and the risk of HCC development in chronic HCV Egyptian patients. Methods: A total of 311 Egyptian patients were enrolled for this study. They were divided into 3 groups: 103 patients with liver Cirrhosis, 107 patients with HCC and 101 normal healthy subjects as the control group. Human genomic DNA Extraction was carried out using QIAamp® DNA Blood Mini Kit (QIAGEN) Genotyping of VDR ApaI (rs7975232) single nucleotide polymorphism (SNP) was carried out using real-time PCR TaqMan allelic discrimination assay with allele-specific designed fluorescent MGB probes. Results: Patients with HCC had a higher frequency of ApaI CC genotype (P=0.035) CI (0.031-0.038). Patients with HCC carried a higher ratio of ApaI CC genotype compared to those with liver cirrhosis (x2=5.4 and P = 0.03) or controls (x2=6.8 and P = 0.01). Univariate analysis revealed that age, lower platelet count (<150×103/μL), higher AFP (>100 ng/ml), and ApaI CC genotype were the factors significantly associated with the development of HCC. Stepwise logistic regression analysis showed that all were independent predictors. Conclusion: ApaI CC VDR gene mutation is an independent risk factor for HCC development in Egyptian Cirrhotic HCV patients.

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