scholarly journals Genome-wide analysis of histone acetylation dynamics during mouse embryonic stem cell neural differentiation

Genomics Data ◽  
2015 ◽  
Vol 5 ◽  
pp. 15-16 ◽  
Author(s):  
Pingyu Liu ◽  
Xiaoyang Dou ◽  
Guangdun Peng ◽  
Jing-Dong Jackie Han ◽  
Naihe Jing
eLife ◽  
2014 ◽  
Vol 3 ◽  
Author(s):  
Sarina Ravens ◽  
Marjorie Fournier ◽  
Tao Ye ◽  
Matthieu Stierle ◽  
Doulaye Dembele ◽  
...  

The histone acetyltransferase (HAT) Mof is essential for mouse embryonic stem cell (mESC) pluripotency and early development. Mof is the enzymatic subunit of two different HAT complexes, MSL and NSL. The individual contribution of MSL and NSL to transcription regulation in mESCs is not well understood. Our genome-wide analysis show that i) MSL and NSL bind to specific and common sets of expressed genes, ii) NSL binds exclusively at promoters, iii) while MSL binds in gene bodies. Nsl1 regulates proliferation and cellular homeostasis of mESCs. MSL is the main HAT acetylating H4K16 in mESCs, is enriched at many mESC-specific and bivalent genes. MSL is important to keep a subset of bivalent genes silent in mESCs, while developmental genes require MSL for expression during differentiation. Thus, NSL and MSL HAT complexes differentially regulate specific sets of expressed genes in mESCs and during differentiation.


PLoS ONE ◽  
2014 ◽  
Vol 9 (5) ◽  
pp. e96281 ◽  
Author(s):  
Talita Glaser ◽  
Sophia La Banca de Oliveira ◽  
Arquimedes Cheffer ◽  
Renata Beco ◽  
Patrícia Martins ◽  
...  

2009 ◽  
Vol 328 (2) ◽  
pp. 456-471 ◽  
Author(s):  
Mijeong Kim ◽  
Ayman Habiba ◽  
Jason M. Doherty ◽  
Jason C. Mills ◽  
Robert W. Mercer ◽  
...  

2021 ◽  
Author(s):  
Hatice Burcu Şişli ◽  
Selinay Şenkal ◽  
Derya Sağraç ◽  
Taha Bartu Hayal ◽  
Ayşegül Doğan

2011 ◽  
Vol 89 (9) ◽  
pp. 1363-1374 ◽  
Author(s):  
Megumi Hirose ◽  
Pawel Niewiadomski ◽  
Gary Tse ◽  
Gloria C. Chi ◽  
Hongmei Dong ◽  
...  

2016 ◽  
Vol 7 (8) ◽  
pp. 601-605
Author(s):  
Xiaoshuang Yan ◽  
Yan Xue ◽  
Yiye Zhou ◽  
Yan Cheng ◽  
Shang Yin ◽  
...  

2008 ◽  
Vol 9 (8) ◽  
pp. R126 ◽  
Author(s):  
Divya Mathur ◽  
Timothy W Danford ◽  
Laurie A Boyer ◽  
Richard A Young ◽  
David K Gifford ◽  
...  

2005 ◽  
Vol 210 (3) ◽  
pp. 175-185 ◽  
Author(s):  
Jan Kramer ◽  
Matthias Klinger ◽  
Charli Kruse ◽  
Marius Faza ◽  
Gunnar Hargus ◽  
...  

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