Bayesian analysis model for the use of anesthetic analgesic drugs in cancer patients based on geometry reconstruction

2019 ◽  
Vol 93 ◽  
pp. 170-175 ◽  
Author(s):  
Zhichao Wu ◽  
Han Wang ◽  
N. Arunkumar
Keyword(s):  
Bayesian Analysis ◽  
Cancer Patients ◽  
Analysis Model ◽  
Analgesic Drugs ◽  
Geometry Reconstruction

scholarly journals Role of Oxycodone Hydrochloride in Treating Radiotherapy-Related Pain

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Yinxia Wang ◽  
Ligang Xing
Keyword(s):  
Quality Of Life ◽  
Side Effects ◽  
Cancer Pain ◽  
Cancer Patients ◽  
Pain Control ◽  
Analgesic Drugs ◽  
Oxycodone Hydrochloride ◽  
Radiation Esophagitis

Radiotherapy is commonly used to treat cancer patients. Besides the curable effect, radiotherapy also could relieve the pain of cancer patients. However, cancer pain is gradually alleviated about two weeks after radiotherapy. In addition, cancer patients who receive radiotherapy may also suffer from pain flare or radiotherapy-induced side effects such as radiation esophagitis, enteritis, and mucositis. Pain control is reported to be inadequate during the whole course of radiotherapy (before, during, and after radiotherapy), and quality of life is seriously affected. Hence, radiotherapy is suggested to be combined with analgesic drugs in clinical guidelines. Previous studies have shown that radiotherapy combined with oxycodone hydrochloride can effectively alleviate cancer pain. In this review, we firstly presented the necessity of analgesia during the whole course of radiotherapy. We also sketched the role of oxycodone hydrochloride in radiotherapy of bone metastases and radiotherapy-induced oral mucositis. Finally, we concluded that oxycodone hydrochloride shows good efficacy and tolerance and could be used for pain management before, during, and after radiotherapy.

scholarly journals Monitoring Radiotherapeutic Response in Prostate Cancer Patients Using High Throughput FTIR Spectroscopy of Liquid Biopsies

Cancers ◽  
2019 ◽  
Vol 11 (7) ◽  
pp. 925 ◽  
Author(s):  
Dinesh K.R. Medipally ◽  
Thi Nguyet Que Nguyen ◽  
Jane Bryant ◽  
Valérie Untereiner ◽  
Ganesh D. Sockalingum ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Blood Plasma ◽  
Ftir Spectroscopy ◽  
Cancer Patients ◽  
Radiation Toxicity ◽  
Plasma Samples ◽  
Analysis Model ◽  
Liquid Biopsies ◽  
Time Points ◽  
Wide Range

Radiation therapy (RT) is used to treat approximately 50% of all cancer patients. However, RT causes a wide range of adverse late effects that can affect a patient’s quality of life. There are currently no predictive assays in clinical use to identify patients at risk of normal tissue radiation toxicity. This study aimed to investigate the potential of Fourier transform infrared (FTIR) spectroscopy for monitoring radiotherapeutic response. Blood plasma was acquired from 53 prostate cancer patients at five different time points: prior to treatment, after hormone treatment, at the end of radiotherapy, two months post radiotherapy and eight months post radiotherapy. FTIR spectra were recorded from plasma samples at all time points and the data was analysed using MATLAB software. Discrimination was observed between spectra recorded at baseline versus follow up time points, as well as between spectra from patients showing minimal and severe acute and late toxicity using principal component analysis. A partial least squares discriminant analysis model achieved sensitivity and specificity rates ranging from 80% to 99%. This technology may have potential to monitor radiotherapeutic response in prostate cancer patients using non-invasive blood plasma samples and could lead to individualised patient radiotherapy.

Analgesic Effect of Auricular Acupuncture for Cancer Pain: A Randomized, Blinded, Controlled Trial

2003 ◽  
Vol 21 (22) ◽  
pp. 4120-4126 ◽  
Author(s):  
David Alimi ◽  
Carole Rubino ◽  
Evelyne Pichard-Léandri ◽  
Sabine Fermand-Brulé ◽  
Marie-Laure Dubreuil-Lemaire ◽  
...  
Keyword(s):  
Cancer Pain ◽  
Pain Intensity ◽  
Cancer Patients ◽  
Controlled Trial ◽  
Auricular Acupuncture ◽  
Analgesic Treatment ◽  
Analgesic Drugs ◽  
The Difference ◽  
Absolute Decrease ◽  
Therapy Treatment

Purpose: During the last 30 years, auricular acupuncture has been used as complementary treatment of cancer pain when analgesic drugs do not suffice. The purpose of this study is to examine the efficacy of auricular acupuncture in decreasing pain intensity in cancer patients.Patients and Methods: Ninety patients were randomly divided in three groups; one group received two courses of auricular acupuncture at points where an electrodermal signal had been detected, and two placebo groups received auricular acupuncture at points with no electrodermal signal (placebo points) and one with auricular seeds fixed at placebo points. Patients had to be in pain, attaining a visual analog score (VAS) of 30 mm or more after having received analgesic treatment adapted to both intensity and type of pain, for at least 1 month of therapy. Treatment efficacy was based on the absolute decrease in pain intensity measured 2 months after randomization using the VAS.Results: The main outcome was pain assessed at 2 months, with the assessment at 1 month carried over to 2 months for the eight patients who interrupted treatment after 1 month. For three patients, no data were available because they withdrew from the study during the first month. Pain intensity decreased by 36% at 2 months from baseline in the group receiving acupuncture; there was little change for patients receiving placebo (2%). The difference between groups was statistically significant (P < .0001).Conclusion: The observed reduction in pain intensity measured on the VAS represents a clear benefit from auricular acupuncture for these cancer patients who are in pain, despite stable analgesic treatment.

Biological dosimetry and Bayesian analysis of chromosomal damage in thyroid cancer patients

2007 ◽  
Vol 129 (4) ◽  
pp. 372-380 ◽  
Author(s):  
A. Serna ◽  
M. Alcaraz ◽  
J. L. Navarro ◽  
C. Acevedo ◽  
V. Vicente ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Bayesian Analysis ◽  
Cancer Patients ◽  
Chromosomal Damage ◽  
Biological Dosimetry

scholarly journals Molecular Profiling for Predictors of Radiosensitivity in Patients with Breast or Head-and-Neck Cancer

Cancers ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 753 ◽  
Author(s):  
Kimi Drobin ◽  
Michal Marczyk ◽  
Martin Halle ◽  
Daniel Danielsson ◽  
Anna Papiez ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Limiting Factor ◽  
Nucleotide Polymorphisms ◽  
Analysis Model ◽  
Term Survival ◽  
Adverse Health Effects ◽  
Normal Tissues

Nearly half of all cancers are treated with radiotherapy alone or in combination with other treatments, where damage to normal tissues is a limiting factor for the treatment. Radiotherapy-induced adverse health effects, mostly of importance for cancer patients with long-term survival, may appear during or long time after finishing radiotherapy and depend on the patient’s radiosensitivity. Currently, there is no assay available that can reliably predict the individual’s response to radiotherapy. We profiled two study sets from breast (n = 29) and head-and-neck cancer patients (n = 74) that included radiosensitive patients and matched radioresistant controls.. We studied 55 single nucleotide polymorphisms (SNPs) in 33 genes by DNA genotyping and 130 circulating proteins by affinity-based plasma proteomics. In both study sets, we discovered several plasma proteins with the predictive power to find radiosensitive patients (adjusted p < 0.05) and validated the two most predictive proteins (THPO and STIM1) by sandwich immunoassays. By integrating genotypic and proteomic data into an analysis model, it was found that the proteins CHIT1, PDGFB, PNKD, RP2, SERPINC1, SLC4A, STIM1, and THPO, as well as the VEGFA gene variant rs69947, predicted radiosensitivity of our breast cancer (AUC = 0.76) and head-and-neck cancer (AUC = 0.89) patients. In conclusion, circulating proteins and a SNP variant of VEGFA suggest that processes such as vascular growth capacity, immune response, DNA repair and oxidative stress/hypoxia may be involved in an individual’s risk of experiencing radiation-induced toxicity.

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