First report of Pandora neoaphidis resting spore formation in vivo in aphid hosts

2012 ◽  
Vol 116 (2) ◽  
pp. 196-203 ◽  
Author(s):  
Ana Clara Scorsetti ◽  
Annette Bruun Jensen ◽  
Claudia López Lastra ◽  
Richard A. Humber
Keyword(s):  
Spore Formation ◽  
First Report ◽  
Resting Spore ◽  
Pandora Neoaphidis

Formation and germination of resting spores from different strains from the Entomophthora muscae complex produced in Musca domestica

2001 ◽  
Vol 79 (9) ◽  
pp. 1076-1082 ◽  
Author(s):  
Lene Thomsen ◽  
José Bresciani ◽  
Jørgen Eilenberg
Keyword(s):  
Musca Domestica ◽  
House Fly ◽  
Spore Production ◽  
Spore Formation ◽  
Entomophthora Muscae ◽  
Resting Spore ◽  
Resting Spores ◽  
Group B ◽  
Different Strains

Three species within the Entomophthora muscae (Cohn) Fresenius complex (Entomophthora schizophorae Keller & Wilding, E. muscae s.str., and E. muscae "group B") were investigated for resting spore formation in vivo in the house fly (Musca domestica L.). Resting spores of E. muscae group B were experimentally induced from August to the beginning of February, while no resting spores were ever observed in E. schizophorae infected M. domestica or in flies infected by E. muscae s.str. originating from M. domestica. When newly dead fly cadavers containing E. muscae group B resting spores were kept moist, cystidia emerged from the abdomen; this is the first report of cystidia in the genus Entomophthora. Resting spore production was significantly affected by both temperature and E. muscae group B strain. More infected flies formed resting spores when kept 1 week at 10°C compared with constant exposure at 22°C, but the tendency of the different E. muscae group B strains to form resting spores persisted with shifting temperatures. After 4 months of incubation under natural winter conditions in Denmark, E. muscae group B resting spores germinated on water agar at 20°C with a 16 h light : 8 h dark photoperiod within 1 week, but no germ conidia were observed.Key words: Entomophthorales, Entomophthora muscae complex, Diptera, Musca domestica, resting spore formation, resting spore germination.

Association of hereditary thrombocythemia and distal limb defects with a thrombopoietin gene mutation

Blood ◽  
2009 ◽  
Vol 114 (8) ◽  
pp. 1655-1657 ◽  
Author(s):  
Claudio Graziano ◽  
Simona Carone ◽  
Emanuele Panza ◽  
Flora Marino ◽  
Pamela Magini ◽  
...  
Keyword(s):  
Human Development ◽  
Gene Mutation ◽  
Autosomal Dominant ◽  
Specific Gene ◽  
Autosomal Dominant Disorder ◽  
Distal Limb ◽  
Limb Defects ◽  
First Report

Abstract Hereditary thrombocythemia is a rare autosomal dominant disorder caused by mutations in either the thrombopoietin gene (TPO) or its receptor c-MPL. TPO mutations described so far lead to thrombopoietin overproduction through increased translation of m-RNA. Unilateral transverse reduction limb defects are usually sporadic and generally thought to be caused by vascular disruptions. Reports of inherited unilateral limb defects are extremely rare. In the present study, we describe a family with segregation of G185T TPO mutation in the 5′ UTR region in 4 subjects with thrombocythemia. Three of these patients also present congenital transverse limb defects. Association of these events gives a strong hint of the in vivo involvement of thrombopoietin in vasculogenesis, confirming the role of TPO in human development of the hemangioblast, the embryonic progenitor of the hematopoietic and endothelial lineages. This is the first report showing that vascular disruptions could be secondary to specific gene derangements.

scholarly journals An advanced universal circulatory assist device for left and right ventricular support: First report of an acute in vivo implant

JTCVS Open ◽  
2020 ◽  
Vol 3 ◽  
pp. 140-148
Author(s):  
Takuma Miyamoto ◽  
Yuichiro Kado ◽  
David J. Horvath ◽  
Barry D. Kuban ◽  
Shiva Sale ◽  
...  
Keyword(s):  
Right Ventricular ◽  
Assist Device ◽  
First Report ◽  
Ventricular Support ◽  
Left And Right

scholarly journals In Vivo Penicillin MIC Drift to Extremely High Resistance in Serotype 14 Streptococcus pneumoniae Persistently Colonizing the Nasopharynx of an Infant with Chronic Suppurative Lung Disease: a Case Study

2002 ◽  
Vol 46 (11) ◽  
pp. 3648-3649 ◽  
Author(s):  
Amanda J. Leach ◽  
Peter S. Morris ◽  
Heidi Smith-Vaughan ◽  
John D. Mathews
Keyword(s):  
Streptococcus Pneumoniae ◽  
Lung Disease ◽  
Chronic Bronchitis ◽  
High Resistance ◽  
Early Onset ◽  
Recurrent Pneumonia ◽  
First Report ◽  
Suppurative Lung Disease

ABSTRACT This is the first report of in vivo pneumococcal penicillin MIC drift from 4.0 to 16.0 mg/liter, possibly associated with alterations in the pbp1a gene. The case presented here is of an infant with early onset recurrent pneumonia and chronic bronchitis requiring repeated antibiotics.

scholarly journals In vivo endogenous spore formation by Coxiella burnetii in Q fever endocarditis.

1994 ◽  
Vol 47 (11) ◽  
pp. 978-981 ◽  
Author(s):  
T F McCaul ◽  
A J Dare ◽  
J P Gannon ◽  
A J Galbraith
Keyword(s):  
Coxiella Burnetii ◽  
Q Fever ◽  
Spore Formation

Evaluation of the profibrinolytic properties of an anti-TAFI monoclonal antibody in a mouse thromboembolism model

Blood ◽  
2011 ◽  
Vol 117 (17) ◽  
pp. 4615-4622 ◽  
Author(s):  
Ellen Vercauteren ◽  
Jan Emmerechts ◽  
Miet Peeters ◽  
Marc F. Hoylaerts ◽  
Paul J. Declerck ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Clot Lysis ◽  
Fibrin Deposition ◽  
Thrombin Activatable Fibrinolysis Inhibitor ◽  
First Report ◽  
Fibrinolysis Inhibitor ◽  
Thrombotic Diseases

Abstract The enhancement of fibrinolysis constitutes a promising approach to treat thrombotic diseases. Activated thrombin activatable fibrinolysis inhibitor (TAFIa) attenuates fibrinolysis and is an attractive target to develop profibrinolytic drugs. TAFI can be activated by thrombin, thrombin/thrombomodulin, or plasmin, but the in vivo physiologic TAFI activator(s) are unknown. Here, we generated and characterized MA-TCK26D6, a monoclonal antibody raised against human TAFI, and examined its profibrinolytic properties in vitro and in vivo. In vitro, MA-TCK26D6 showed a strong profibrinolytic effect caused by inhibition of the plasmin-mediated TAFI activation. In vivo, MA-TCK26D6 significantly decreased fibrin deposition in the lungs of thromboembolism-induced mice. Moreover, in the presence of MA-TCK26D6, plasmin-α2-antiplasmin complexes in plasma of thromboembolism-induced mice were significantly increased compared with a control antibody, indicative of an acceleration of fibrinolysis through MA-TCK26D6. In this study, we show that plasmin is an important TAFI activator that hampers in vitro clot lysis. Furthermore, this is the first report on an anti-TAFI monoclonal antibody that demonstrates a strong profibrinolytic effect in a mouse thromboembolism model.

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