Phase stability testing near the stability test limit

2016 ◽  
Vol 426 ◽  
pp. 25-36 ◽  
Author(s):  
Dan Vladimir Nichita
Keyword(s):  
Phase Stability ◽  
Stability Test ◽  
Stability Testing ◽  
The Stability

scholarly journals Ekstraksi dan Uji Stabilitas Zat Warna Alami dari Bayam Merah (Alternanthera amoena Voss)

KOVALEN ◽  
2020 ◽  
Vol 6 (3) ◽  
pp. 212-217
Author(s):  
Khairuddin ◽  
Joy Noldy Baciang ◽  
Indriani ◽  
Nov Irmawati Inda
Keyword(s):  
Sun Exposure ◽  
Natural Dye ◽  
Natural Dyes ◽  
Stability Test ◽  
Stability Testing ◽  
Effect Of Ph ◽  
Color Degradation ◽  
The Stability ◽  
Better Than

Research on the extraction and stability test of natural dye from red spinach (Alternanthera amoena Voss) has been carried out. This study aims to determine the effect of pH and length of sun exposure on the stability of the dye from red spinach. Extraction using the maceration method with ethanol solvent and measurement using a UV-Vis spectrophotometer. Stability testing is carried out at pH 2-5 and sun exposure for 1-4 hours using a dark and light container. The results obtained, at pH 2 and pH 3, anthocyanins were more stable, compared to pH 4 and 5 which had greater color degradation. In exposure to sunlight, dark containers with a degradation percentage of 31.70% were better than clear containers with a percentage of 48.78%. Keywords: Anthocyanin, red spinach, natural dyes stability.

Stability Testing of Pharmaceutical Products

2021 ◽  
pp. 317-328
Author(s):  
Yashpal Singh Chauhan ◽  
Ravi Nex ◽  
Ghanshyam Sevak ◽  
Mahendra Singh Rathore
Keyword(s):  
Pharmaceutical Products ◽  
Test Methods ◽  
Pharmaceutical Product ◽  
Stability Test ◽  
World Health ◽  
Stability Testing ◽  
Container Closure ◽  
The Stability ◽  
Main Components ◽  
Health Organization

Stability studies must be carried out according to the guidelines provided by the International Conference of Harmonization, World Health Organization, and other agencies in a scheduled manner. The pharmaceutical product’s stability can be defined as the ability, within its physical, chemical, microbiological, toxicology, protective, and informational requirements of a particular formulation in a specific container-closure system. It also guarantees that the performance, safety, and efficacy are maintained throughout the shelf life of any pharmaceutical product which is considered as pre-requisite for acceptance and approval. Different stability test methods have originated with the need for constant monitoring of drugs and products for their quality and purity. In this review, we have included the types of stability of drugs substances, the relevance of different methods used to test the stability of the pharmaceutical product, guidelines issued to test the stability of pharmaceuticals, stability testing protocols which describes the main components of a well-controlled and regulated stability test and other aspects of stability.

scholarly journals An improved reduction method for phase stability testing in the single-phase region

2020 ◽  
Vol 18 (1) ◽  
pp. 1316-1322
Author(s):  
Dan Vladimir Nichita ◽  
Catinca Secuianu
Keyword(s):  
Phase Stability ◽  
Reduction Method ◽  
Phase Region ◽  
Binary Interaction ◽  
Stability Testing ◽  
Number Of Components ◽  
Mixture Phase ◽  
Residual Functions ◽  
Binary Interaction Parameters ◽  
The Stability

AbstractA new reduction method for mixture phase stability testing is proposed, consisting in Newton iterations with a particular set of independent variables and residual functions. The dimension of the problem does not depend on the number of components but on the number of components with nonzero binary interaction parameters in the equation of state. Numerical experiments show an improved convergence behavior, mainly for the domain located outside the stability test limit locus in the pressure–temperature plane, recommending the proposed method for any applications in which the problematic domain is crossed a very large number of times during simulations.

scholarly journals A REVIEW ON STABILITY TESTING GUIDELINES OF PHARMACEUTICAL PRODUCTS

2020 ◽  
pp. 3-9
Author(s):  
ZOTHANPUII F ◽  
RAJESH R ◽  
SELVAKUMAR K
Keyword(s):  
Pharmaceutical Products ◽  
Test Methods ◽  
Pharmaceutical Product ◽  
Stability Test ◽  
World Health ◽  
Stability Testing ◽  
Container Closure ◽  
The Stability ◽  
Main Components ◽  
Health Organization

Stability studies must be carried out according to the guidelines provided by the International Conference of Harmonization, World Health Organization, and other agencies in a scheduled manner. The pharmaceutical product’s stability can be defined as the ability, within its physical, chemical, microbiological, toxicology, protective, and informational requirements of a particular formulation in a specific container-closure system. It also guarantees that the performance, safety, and efficacy are maintained throughout the shelf life of any pharmaceutical product which is considered as pre-requisite for acceptance and approval. Different stability test methods have originated with the need for constant monitoring of drugs and products for their quality and purity. In this review, we have included the types of stability of drugs substances, the relevance of different methods used to test the stability of the pharmaceutical product, guidelines issued to test the stability of pharmaceuticals, stability testing protocols which describes the main components of a well-controlled and regulated stability test and other aspects of stability.

Tuning the phase stability and surface HER activity of 1T′-MoS2 by covalent chemical functionalization

2020 ◽  
Vol 8 (44) ◽  
pp. 15852-15859
Author(s):  
Jiu Chen ◽  
Fuhua Li ◽  
Yurong Tang ◽  
Qing Tang
Keyword(s):  
Phase Stability ◽  
Chemical Functionalization ◽  
The Stability

Chemical functionalization can significantly improve the stability of meta-stable 1T′-MoS2 and tune the surface HER activity.

scholarly journals Research on Suppression Method of Power Noise in the Stability Test Device

2021 ◽  
Vol 645 ◽  
pp. 012027
Author(s):  
Junhao Huang ◽  
Fang Fang ◽  
Zhihua Wang ◽  
Mingxuan Hang ◽  
Yibo Wang ◽  
...  
Keyword(s):  
Stability Test ◽  
Test Device ◽  
Suppression Method ◽  
Power Noise ◽  
The Stability

scholarly journals Stability and Compatibility Aspects of Drugs: The Case of Selected Cephalosporins

Antibiotics ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 549
Author(s):  
Szymon Tomczak ◽  
Aleksandra Gostyńska ◽  
Malwina Nadolna ◽  
Karolina Reisner ◽  
Marta Orlando ◽  
...  
Keyword(s):  
Parenteral Nutrition ◽  
Treatment Failure ◽  
Medical Errors ◽  
Stability Test ◽  
Intravenous Drug ◽  
Common Cause ◽  
Life Threatening ◽  
Degradation Studies ◽  
The Stability ◽  
Infusion Fluids

Intravenous drug incompatibilities are a common cause of medical errors, contributing to ineffective therapy and even life-threatening events. The co-administration of drugs must always be supported by studies confirming compatibility and thus guarantee the therapy’s safety. Particular attention should be paid to the possible incompatibilities or degradation of intravenous cephalosporins in different infusion regimens since the administration of drugs with inadequate quality may cause treatment failure. Therefore, an appropriate stability test should be performed. The study aimed to present various aspects of the stability and compatibility of five cephalosporins: cefepime (CFE), cefuroxime (CFU), ceftriaxone (CFX), ceftazidime (CFZ), and cefazoline (CFL). The degradation studies in parenteral infusion fluids and PN admixtures were conducted for CFE and CFU. The interactions between CFX or CFZ and PN admixtures, as well as the compatibility of CFL with five commercial parenteral nutrition (PN) admixtures, were investigated. The content of CFX and CFZ in PN admixture after 24 h was >90%. CFL administered simultaneously with PN admixture by the same infusion set using Y-site was compatible only with Nutriflex Lipid Special. CFE and CFU were stable in all tested infusion fluids for a minimum of 48 h and decomposed in PN admixtures during storage.

Formulation and Stability Test of Lip Cream Preparation of Kenop Flower Ethanol Extract (Gomphrena globosa L.)

2021 ◽  
Vol 3 (2) ◽  
Author(s):  
Mevi Irianti Tonapa ◽  
Rani Dewi Pratiwi ◽  
Elsye Gunawan
Keyword(s):  
Ph Value ◽  
Ethanol Extract ◽  
Stability Test ◽  
Gomphrena Globosa ◽  
Homogeneous Composition ◽  
Semi Solid ◽  
The Stability ◽  
Ph Range ◽  
Average Dispersion ◽  
Brown Color

Kenop Flower (Gomphrena globosa L.) is used in the manufacture of lip cream because contains betacyanin pigments that function as color pigments. This study aims to determine the physical quality and stability of the lip cream preparation of the ethanol extract of kenop flower (Gomphrena globosa L.). This research was conducted experimentally, including the manufacture of lip cream formulations with ethanol extract of kenop flower (Gomphrena globosa L.) with a concentration of 10%. The results of the physical examination test for lip cream preparations for all preparations have a distinctive vanilla aroma with a semi-solid texture, F0 has ivory white color and F1-F3 has a brown color. The preparations had a homogeneous composition, average pH 6-7, had good greasing power, 5.0-5.8 average dispersion and 60.33-66.67 seconds average adhesion. The stability test carried out on day 28 found that all preparations were stable, had a distinctive vanilla aroma with a semi-solid texture, F0 had ivory white color and F1-F3 had a brown color. The preparation has a homogeneous composition; the average pH is 6-7. Where the lip cream formulas F1 and F3 decreased the pH value on the 28th day from 7 to 6 but tended to be stable and in the pH range that matched the lip pH. And there is no phase separation in all formulas.

scholarly journals Morphology, Stability, and Application of Lycopene Microcapsules Produced by Complex Coacervation

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Glaucia A. Rocha-Selmi ◽  
Carmen S. Favaro-Trindade ◽  
Carlos R. F. Grosso
Keyword(s):  
Encapsulation Efficiency ◽  
Gum Arabic ◽  
Average Diameter ◽  
Stability Test ◽  
Free Form ◽  
Complex Coacervation ◽  
The Stability ◽  
Processing And Storage ◽  
High Degree ◽  
And Storage

The interest in lycopene has increased in recent years due to studies that associate it with the reduction in risk of developing cardiovascular diseases and cancer. However, due to its high degree of unsaturation, this carotenoid is inclined to isomerize and oxidize during processing and storage, making it difficult to use in the food industry. Microencapsulation can improve this situation, increasing its stability and making incorporation into food formulations possible. Thus, the aim of this study was to microencapsulate lycopene by complex coacervation using gelatin and gum Arabic as the encapsulating agents. The microcapsules were evaluated based on the encapsulation efficiency and their morphology and then submitted to a stability test and applied in cake making. Most of the systems studied presented spherical microcapsules with defined walls. The encapsulation efficiency values were above 90%, and the average diameter of the capsules ranged from 61 to 144 μm. The stability test showed that microencapsulation offered greater protection to the lycopene as compared to its free form. The application of nonfreeze dried coacervated microcapsules in cake making was satisfactory, but the color transference was low when freezedried coacervated microcapsules were used.

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