scholarly journals Ubiquitin-specific protease 4 promotes TNF-α-induced apoptosis by deubiquitination of RIP1 in head and neck squamous cell carcinoma

FEBS Letters ◽  
2013 ◽  
Vol 587 (4) ◽  
pp. 311-316 ◽  
Author(s):  
Xiaozhi Hou ◽  
Lijuan Wang ◽  
Lei Zhang ◽  
Xinliang Pan ◽  
Wei Zhao
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Tnf Α ◽  
Specific Protease ◽  
Ubiquitin Specific Protease ◽  
Induced Apoptosis

scholarly journals Association of −308 TNF-α promoter polymorphism with clinical aggressiveness in patients with head and neck squamous cell carcinoma

Oral Oncology ◽  
2011 ◽  
Vol 47 (9) ◽  
pp. 888-894 ◽  
Author(s):  
Gefter Thiago Batista Corrêa ◽  
Gabriela Alencar Bandeira ◽  
Bruna Gonçalves Cavalcanti ◽  
Carlos Alberto de Carvalho Fraga ◽  
Erivelton Pereira dos Santos ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Promoter Polymorphism ◽  
Neck Squamous Cell Carcinoma ◽  
Tnf Α

scholarly journals MiR-21 is a Predictor for Chemoradioresistance and a Novel Therapeutic Target in Head and Neck Squamous Cell Carcinoma

2021 ◽  
Author(s):  
Hajime Ishinaga ◽  
Yoshinaga Okugawa ◽  
Bo Hou ◽  
Feng He ◽  
Chengzeng Yin ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Western Blot ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Predictive Biomarker ◽  
Neck Squamous Cell Carcinoma ◽  
Potential Target ◽  
Programmed Cell Death 4 ◽  
Induced Apoptosis

Abstract ObjectiveThis study aimed to clarify whether circulating miR-21 represents a predictive biomarker in patients with head and neck squamous cell carcinoma (HNSCC) undergoing chemoradiotherapy, and to investigate the effect of miR-21 inhibitor for chemoradiation in human SCC cells.MethodsPlasma samples were obtained from 22 patients with HNSCC and 25 non-cancer volunteers. Plasma miR-21 expression was measured using real-time quantitative reverse transcription polymerase chain reaction. The effects of miR-21 inhibitor in human SCC cells were investigated by performing 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, flow cytometry, and Western blot analysis.ResultsPlasma miR-21 expression was higher in HNSCC patients than in control patients (p< 0.001). Seven patients with recurrence showed significantly higher plasma miR-21 than the 15 patients without recurrence. Moreover, miR-21 inhibition significantly enhanced cisplatin- or radiation-induced apoptosis. Western blot analysis suggested the programmed cell death 4 (PDCD4) protein as a potential target of miR-21 in relation to apoptosis. Adding miR-21 inhibition to radiation or cisplatin treatment provided clear and potent suppression of tumor cell proliferation.ConclusionThis study provides new insights into the role of miR-21 as a predictive biomarker for HNSCC treated with chemoradiotherapy, and suggests a potential target to improve the effects of chemoradiotherapy against HNSCC.

scholarly journals TNF-α promotes tumor lymph angiogenesis in head and neck squamous cell carcinoma through regulation of ERK3

2019 ◽  
Vol 8 (6) ◽  
pp. 2439-2448
Author(s):  
Caiyun Zhang ◽  
Minhui Zhu ◽  
Wei Wang ◽  
Donghui Chen ◽  
Shicai Chen ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Tnf Α

scholarly journals HOXC6 Is Deregulated in Human Head and Neck Squamous Cell Carcinoma and Modulates Bcl-2 Expression

2012 ◽  
Vol 287 (42) ◽  
pp. 35678-35688 ◽  
Author(s):  
Sung-Min Moon ◽  
Soo-A Kim ◽  
Jung-Hoon Yoon ◽  
Sang-Gun Ahn
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Protein A ◽  
Human Head ◽  
Neck Squamous Cell Carcinoma ◽  
Luciferase Reporter ◽  
Apoptotic Pathway ◽  
Induced Apoptosis

Homeobox C6 (HOXC6) genes belong to the homeoprotein family of transcription factors, which play an important role in morphogenesis and cellular differentiation during embryonic development. The aim of this study was to explore the role of HOXC6 in the regulation of Bcl-2 in human head and neck squamous cell carcinoma (HNSCC). The HOXC6 and Bcl-2 gene were identified as being overexpressed in HNSCC tissue and cell lines. Transfection assays demonstrated that HOXC6 increased the levels of Bcl-2 mRNA and protein. A luciferase reporter assay suggested that HOXC6 induced activity of the Bcl-2 promoter. A series of Bcl-2 promoter deletion mutants were examined and the minimal HOXC6-responsive region was identified to be in the TAAT motif (-420 bp) of the Bcl-2 promoter. Interestingly, the inhibition of HOXC6 using siRNA led to the repression of Bcl-2 expression and induced caspase-3-dependent apoptosis; overexpression of HOXC6 in HNSCC cells increased the resistance to paclitaxel-induced apoptosis. Together, our findings suggest that HOXC6 is an important mechanism of the anti-apoptotic pathway via regulation of Bcl-2 expression.

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