scholarly journals Site-specific cleavage of mutant ABL mRNA by DNAzyme is facilitated by peptide nucleic acid binding to RNA substrate

FEBS Letters ◽  
2012 ◽  
Vol 586 (21) ◽  
pp. 3865-3869 ◽  
Author(s):  
Ji Eun Kim ◽  
Soojin Yoon ◽  
Hyejung Mok ◽  
Woong Jung ◽  
Dong-Eun Kim
Keyword(s):  
Nucleic Acid ◽  
Peptide Nucleic Acid ◽  
Nucleic Acid Binding ◽  
Site Specific

scholarly journals Site-specific conjugation of recognition tags to trastuzumab for peptide nucleic acid-mediated radionuclide HER2 pretargeting

Biomaterials ◽  
2019 ◽  
Vol 203 ◽  
pp. 73-85 ◽  
Author(s):  
Kristina Westerlund ◽  
Anzhelika Vorobyeva ◽  
Bogdan Mitran ◽  
Anna Orlova ◽  
Vladimir Tolmachev ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Peptide Nucleic Acid ◽  
Site Specific

scholarly journals 2P116 NMR analysis of HAC1 mRNA recognized by the site-specific endonuclease Ire1p(04. Nucleic acid binding proteins,Poster)

2013 ◽  
Vol 53 (supplement1-2) ◽  
pp. S178
Author(s):  
Ikumi Kawahara ◽  
Yuta Ashihara ◽  
Kaichiro Haruta ◽  
Yoshiyuki Tanaka ◽  
Chojiro Kojima
Keyword(s):  
Nucleic Acid ◽  
Binding Proteins ◽  
Nucleic Acid Binding ◽  
Nmr Analysis ◽  
Site Specific ◽  
Nucleic Acid Binding Proteins

Insight into why pyrrolidinyl peptide nucleic acid binding to DNA is more stable than the DNA·DNA duplex

2008 ◽  
Vol 372 (4) ◽  
pp. 765-771 ◽  
Author(s):  
Khatcharin Siriwong ◽  
Parawan Chuichay ◽  
Suwipa Saen-oon ◽  
Chaturong Suparpprom ◽  
Tirayut Vilaivan ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Peptide Nucleic Acid ◽  
Nucleic Acid Binding ◽  
Insight Into

Quinoxaline Antibiotics Enhance Peptide Nucleic Acid Binding to Double-Stranded DNA†

Biochemistry ◽  
2000 ◽  
Vol 39 (31) ◽  
pp. 9502-9507 ◽  
Author(s):  
Niels Erik Møllegaard ◽  
Christian Bailly ◽  
Michael J. Waring ◽  
Peter E. Nielsen
Keyword(s):  
Nucleic Acid ◽  
Peptide Nucleic Acid ◽  
Nucleic Acid Binding ◽  
Double Stranded Dna

An Overview of Computational Tools of Nucleic Acid Binding Site Prediction for Site-specific Proteins and Nucleases

2020 ◽  
Vol 27 (5) ◽  
pp. 370-384
Author(s):  
Hua Wan ◽  
Jian-ming Li ◽  
Huang Ding ◽  
Shuo-xin Lin ◽  
Shu-qin Tu ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Binding Site ◽  
Genome Editing ◽  
Computational Methods ◽  
Target Prediction ◽  
Support Vector ◽  
Nucleic Acid Binding ◽  
Computational Tools ◽  
Site Specific ◽  
Specific Proteins

: Understanding the interaction mechanism of proteins and nucleic acids is one of the most fundamental problems for genome editing with engineered nucleases. Due to some limitations of experimental investigations, computational methods have played an important role in obtaining the knowledge of protein-nucleic acid interaction. Over the past few years, dozens of computational tools have been used for identification of nucleic acid binding site for site-specific proteins and design of site-specific nucleases because of their significant advantages in genome editing. Here, we review existing widely-used computational tools for target prediction of site-specific proteins as well as off-target prediction of site-specific nucleases. This article provides a list of on-line prediction tools according to their features followed by the description of computational methods used by these tools, which range from various sequence mapping algorithms (like Bowtie, FetchGWI and BLAST) to different machine learning methods (such as Support Vector Machine, hidden Markov models, Random Forest, elastic network and deep neural networks). We also make suggestions on the further development in improving the accuracy of prediction methods. This survey will provide a reference guide for computational biologists working in the field of genome editing.

scholarly journals Kinetics and mechanism of polyamide ("peptide") nucleic acid binding to duplex DNA.

1995 ◽  
Vol 92 (7) ◽  
pp. 2637-2641 ◽  
Author(s):  
V. V. Demidov ◽  
M. V. Yavnilovich ◽  
B. P. Belotserkovskii ◽  
M. D. Frank-Kamenetskii ◽  
P. E. Nielsen
Keyword(s):  
Nucleic Acid ◽  
Peptide Nucleic Acid ◽  
Kinetics And Mechanism ◽  
Duplex Dna ◽  
Nucleic Acid Binding
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