scholarly journals Splice blocking of zygotic sox31 leads to developmental arrest shortly after Mid-Blastula Transition and induces apoptosis in zebrafish

FEBS Letters ◽  
2011 ◽  
Vol 586 (3) ◽  
pp. 222-228 ◽  
Author(s):  
Sheng-Nan Hu ◽  
Hui Yu ◽  
Yun-Bin Zhang ◽  
Zhi-Li Wu ◽  
Yuan-Chang Yan ◽  
...  
Keyword(s):  
Developmental Arrest

Two mutations in TUBB8 cause developmental arrest in human oocytes and early embryos

2021 ◽  
Author(s):  
Tianqi Cao ◽  
Jing Guo ◽  
Yan Xu ◽  
Xiufeng Lin ◽  
Weifen Deng ◽  
...  
Keyword(s):  
Human Oocytes ◽  
Developmental Arrest ◽  
Early Embryos

Developmental arrest in vent worm embryos

Nature ◽  
2001 ◽  
Vol 413 (6857) ◽  
pp. 698-699 ◽  
Author(s):  
Florence Pradillon ◽  
Bruce Shillito ◽  
Craig M. Young ◽  
Françoise Gaill
Keyword(s):  
Developmental Arrest

Developmental Arrest and Cytoskeletal Anomalies of Rat Embryos Reconstructed by Somatic Cell Nuclear Transfer

2007 ◽  
Vol 9 (3) ◽  
pp. 382-393 ◽  
Author(s):  
Jae Gyu Yoo ◽  
Simon-Pierre Demers ◽  
Li Lian ◽  
Lawrence C. Smith
Keyword(s):  
Somatic Cell ◽  
Somatic Cell Nuclear Transfer ◽  
Nuclear Transfer ◽  
Rat Embryos ◽  
Developmental Arrest

Genetic characterization of ms (3) K81, a paternal effect gene of Drosophila melanogaster.

Genetics ◽  
1995 ◽  
Vol 140 (1) ◽  
pp. 219-229 ◽  
Author(s):  
G K Yasuda ◽  
G Schubiger ◽  
B T Wakimoto
Keyword(s):  
Drosophila Melanogaster ◽  
Developmental Stages ◽  
Normal Function ◽  
Loss Of Function ◽  
Male Sterile ◽  
Specific Product ◽  
Paternal Effect ◽  
Developmental Arrest ◽  
Effect Gene

Abstract The vast majority of known male sterile mutants of Drosophila melanogaster fail to produce mature sperm or mate properly. The ms(3) K81(1) mutation is one of a rare class of male sterile mutations in which sterility is caused by developmental arrest after sperm entry into the egg. Previous studies showed that males homozygous for the K81(1) mutation produce progeny that arrest at either of two developmental stages. Most embryos arrest during early nuclear cycles, whereas the remainder are haploid embryos that arrest at a later stage. This description of the mutant phenotype was based on the analysis of a single allele isolated from a natural population. It was therefore unclear whether this unique paternal effect phenotype reflected the normal function of the gene. The genetic analysis and initial molecular characterization of five new K81 mutations are described here. Hemizygous conditions and heteroallelic combinations of the alleles were associated with male sterility caused by defects in embryogenesis. No other mutant phenotypes were observed. Thus, the K81 gene acted as a strict paternal effect gene. Moreover, the biphasic pattern of developmental arrest was common to all the alleles. These findings strongly suggested that the unusual embryonic phenotype caused by all five new alleles was due to loss of function of the K81+ gene. The K81 gene is therefore the first clear example of a strict paternal effect gene in Drosophila. Based on the embryonic lethal phenotypes, we suggest that the K81+ gene encodes a sperm-specific product that is essential for the male pronucleus to participate in the first few embryonic nuclear divisions.

scholarly journals Pathological satiety caused by brainstem hemangioblastoma

2008 ◽  
Vol 2 (6) ◽  
pp. 397-401 ◽  
Author(s):  
Debbie K. Song ◽  
Russell R. Lonser
Keyword(s):  
Tumor Resection ◽  
Sensory Impairment ◽  
Rapid Weight Gain ◽  
Lower Cranial Nerve ◽  
Von Hippel Lindau ◽  
Developmental Arrest ◽  
Cranial Nerve Dysfunction ◽  
Nerve Dysfunction ◽  
Gait Abnormalities ◽  
Vhl Disease

Because of the multiplicity and saltatory growth pattern associated with central nervous system hemangioblastomas in von Hippel-Lindau (VHL) disease, resection of individual tumors is usually reserved until symptoms occur, to avoid unnecessary surgery over the lifetime of a patient. Brainstem hemangioblastomas in VHL typically cause lower cranial nerve dysfunction, long-tract signs, sensory impairment, and gait abnormalities. The authors report on a 16-year-old girl with VHL who presented with abnormal early satiety resulting in growth and developmental arrest associated with a growing obex hemangioblastoma. Tumor resection resulted in restoration of appetite, with rapid weight gain, growth in stature, and onset of menses. These findings indicate that caudal brainstem-mediated mechanisms have a profound effect on satiety. Moreover, brainstem hemangioblastomas may present with abnormalities in satiety and feeding that can be effectively reversed with resection.

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