scholarly journals Identification ofptproas a novel target gene of Wnt signaling and its potential role as a receptor for Wnt

FEBS Letters ◽  
2010 ◽  
Vol 584 (18) ◽  
pp. 3923-3928 ◽  
Author(s):  
Minseong Kim ◽  
Hanjun Kim ◽  
Eek-hoon Jho
Keyword(s):  
Wnt Signaling ◽  
Target Gene ◽  
Potential Role ◽  
Novel Target

MPC1 is essential for PGC-1α-induced mitochondrial respiration and biogenesis

2018 ◽  
Vol 475 (10) ◽  
pp. 1687-1699 ◽  
Author(s):  
Eunjin Koh ◽  
Young Kyung Kim ◽  
Daye Shin ◽  
Kyung-Sup Kim
Keyword(s):  
Target Gene ◽  
Peroxisome Proliferator ◽  
Mitochondrial Matrix ◽  
Strong Suppression ◽  
Mitochondrial Oxygen Consumption ◽  
Peroxisome Proliferator Activated Receptor ◽  
Human Renal Cell Carcinoma ◽  
Mitochondrial Pyruvate Carrier ◽  
Novel Target ◽  
Estrogen Related Receptor

Mitochondrial pyruvate carrier (MPC), which is essential for mitochondrial pyruvate usage, mediates the transport of cytosolic pyruvate into mitochondria. Low MPC expression is associated with various cancers, and functionally associated with glycolytic metabolism and stemness. However, the mechanism by which MPC expression is regulated is largely unknown. In this study, we showed that MPC1 is down-regulated in human renal cell carcinoma (RCC) due to strong suppression of peroxisome proliferator-activated receptor-gamma co-activator (PGC)-1 alpha (PGC-1α). We also demonstrated that overexpression of PGC-1α stimulates MPC1 transcription, while depletion of PGC-1α by siRNA suppresses MPC expression. We found that PGC-1α interacts with estrogen-related receptor-alpha (ERR-α) and recruits it to the ERR-α response element motif located in the proximal MPC1 promoter, resulting in efficient activation of MPC1 expression. Furthermore, the MPC inhibitor, UK5099, blocked PGC-1α-induced pyruvate-dependent mitochondrial oxygen consumption. Taken together, our results suggest that MPC1 is a novel target gene of PGC-1α. In addition, low expression of PGC-1α in human RCC might contribute to the reduced expression of MPC, resulting in impaired mitochondrial respiratory capacity in RCC by limiting the transport of pyruvate into the mitochondrial matrix.

Regulation of Wnt Signaling Target Gene Expression by the Histone Methyltransferase DOT1L

2014 ◽  
Vol 10 (1) ◽  
pp. 109-114 ◽  
Author(s):  
Garrett S. Gibbons ◽  
Scott R. Owens ◽  
Eric R. Fearon ◽  
Zaneta Nikolovska-Coleska
Keyword(s):  
Gene Expression ◽  
Wnt Signaling ◽  
Target Gene ◽  
Histone Methyltransferase ◽  
Target Gene Expression

CARD11 is a novel target of miR-181b that is upregulated in chronic lymphocytic leukemia

2021 ◽  
Author(s):  
Zhen Kou ◽  
Min Mao ◽  
Hong Liu ◽  
Xiaomin Wang ◽  
Zengsheng Wang ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Target Gene ◽  
Target Genes ◽  
Prognostic Indicator ◽  
Lymphocytic Leukemia ◽  
Poor Survival ◽  
Kaplan Meier ◽  
Poor Prognostic Indicator ◽  
Novel Target

Aim: To investigate the targets of miR-181b in patients with chronic lymphocytic leukemia (CLL). Materials & methods: The bioinformatic softwares were used to indicate the key target genes associated with miR-181b, and the results were verified in CLL patient samples and 293T cells. Results: CARD11 is a potential target gene of miR-181b, an inverse relationship was revealed between the expression of CARD11 and miR-181b in 104 CLL patients, and it was confirmed in vitro with luciferase assays and western blotting. Kaplan–Meier analysis showed that CLL patients with high CARD11 expression demonstrated poor survival. Conclusion: CARD11 is a novel target of miR-181b that is upregulated, which could be a poor prognostic indicator for CLL patients.

The Alpha-1-Fetoprotein (AFP) – A novel target gene for p63

2021 ◽  
Author(s):  
K Gülow ◽  
E Ostheim ◽  
M Müller-Schilling
Keyword(s):  
Target Gene ◽  
Novel Target

scholarly journals Expression of osteopontin, a target gene of de-regulated Wnt signaling, predicts survival in colon cancer

2007 ◽  
Vol 121 (8) ◽  
pp. 1717-1723 ◽  
Author(s):  
Franziska Rohde ◽  
Caroline Rimkus ◽  
Jan Friederichs ◽  
Robert Rosenberg ◽  
Carmen Marthen ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Wnt Signaling ◽  
Target Gene

WNT1 inducible signaling pathway protein 3, WISP-3, a novel target gene in colorectal carcinomas with microsatellite instability

2001 ◽  
Vol 121 (6) ◽  
pp. 1275-1280 ◽  
Author(s):  
Lin Thorstensen ◽  
Chieu B. Diep ◽  
Gunn I. Meling ◽  
Trude H. Aagesen ◽  
Christian H. Ahrens ◽  
...  
Keyword(s):  
Microsatellite Instability ◽  
Signaling Pathway ◽  
Target Gene ◽  
Colorectal Carcinomas ◽  
Novel Target

scholarly journals Myocyte-specific enhancer factor 2C: a novel target gene of miR-214-3p in suppressing angiotensin II-induced cardiomyocyte hypertrophy

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Chun-Mei Tang ◽  
Fang-zhou Liu ◽  
Jie-Ning Zhu ◽  
Yong-Heng Fu ◽  
Qiu-Xiong Lin ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Target Gene ◽  
Cardiomyocyte Hypertrophy ◽  
Novel Target ◽  
Enhancer Factor

scholarly journals The CDK inhibitor p21 is a novel target gene of ATF4 and contributes to cell survival under ER stress

FEBS Letters ◽  
2017 ◽  
Vol 591 (21) ◽  
pp. 3682-3691 ◽  
Author(s):  
Yasumichi Inoue ◽  
Shiori Kawachi ◽  
Tsubasa Ohkubo ◽  
Mai Nagasaka ◽  
Shogo Ito ◽  
...  
Keyword(s):  
Er Stress ◽  
Cell Survival ◽  
Target Gene ◽  
Cdk Inhibitor ◽  
Novel Target
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