scholarly journals Fibroblast growth factor signaling in embryonic and cancer stem cells

FEBS Letters ◽  
2006 ◽  
Vol 580 (12) ◽  
pp. 2869-2874 ◽  
Author(s):  
Petr Dvorak ◽  
Dana Dvorakova ◽  
Ales Hampl
Keyword(s):  
Stem Cells ◽  
Growth Factor ◽  
Cancer Stem Cells ◽  
Fibroblast Growth Factor ◽  
Growth Factor Signaling ◽  
Fibroblast Growth ◽  
Fibroblast Growth Factor Signaling

scholarly journals Fibroblast Growth Factor Signaling Is Essential for Self-renewal of Dental Epithelial Stem Cells

2013 ◽  
Vol 288 (40) ◽  
pp. 28952-28961 ◽  
Author(s):  
Julia Yu Fong Chang ◽  
Cong Wang ◽  
Junchen Liu ◽  
Yanqing Huang ◽  
Chengliu Jin ◽  
...  
Keyword(s):  
Stem Cells ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Growth Factor Signaling ◽  
Fibroblast Growth ◽  
Epithelial Stem Cells ◽  
Fibroblast Growth Factor Signaling ◽  
Self Renewal

scholarly journals ADAMDEC1 maintains a novel growth factor signaling loop in cancer stem cells

2019 ◽  
Author(s):  
James S. Hale ◽  
Ana Jimenez-Pascual ◽  
Anja Kordowski ◽  
Jamie Pugh ◽  
Shilpa Rao ◽  
...  
Keyword(s):  
Stem Cells ◽  
Growth Factor ◽  
Cancer Stem Cells ◽  
Tumor Growth ◽  
Fibroblast Growth Factor ◽  
Cellular Heterogeneity ◽  
Growth Factor Signaling ◽  
Fibroblast Growth ◽  
Signaling Axis ◽  
A Disintegrin And Metalloproteinase

AbstractGlioblastomas (GBM) are lethal brain tumors where poor outcome is attributed to cellular heterogeneity, therapeutic resistance, and a highly infiltrative nature. These characteristics are preferentially linked to GBM cancer stem cells (GSCs), but how GSCs maintain their stemness is incompletely understood and the subject of intense investigation. Here, we identify a novel signaling loop that induces and maintains GSCs. This loop consists of an atypical metalloproteinase, a disintegrin and metalloproteinase domain-like protein decysin 1 (ADAMDEC1), secreted by GSCs. ADAMDEC1 rapidly solubilizes fibroblast growth factor-2 (FGF2) to stimulate FGF receptor 1 (FGFR1) expressed on GSCs. This signaling axis induces upregulation of Zinc finger E-box-binding homeobox 1 (ZEB1) that regulates ADAMDEC1 expression, creating a positive feedback loop. Genetic or pharmacological targeting of components of this axis attenuates self-renewal and tumor growth. These findings reveal a new signaling axis for GSC maintenance and highlight ADAMDEC1 and FGFR1 as potential therapeutic targets in GBM.Statement of SignificanceCancer stem cells (CSC) drive tumor growth in many cancers including glioblastoma. We identified a novel sheddase, a disintegrin and metalloproteinase domain-like protein decysin 1, that initiates a fibroblast growth factor autocrine loop to promote stemness in CSCs. This loop can be targeted to reduce glioblastoma growth.

scholarly journals Sulfatase 2 up-regulates glypican 3, promotes fibroblast growth factor signaling, and decreases survival in hepatocellular carcinoma

Hepatology ◽  
2008 ◽  
Vol 47 (4) ◽  
pp. 1211-1222 ◽  
Author(s):  
Jin-Ping Lai ◽  
Dalbir S. Sandhu ◽  
Chunrong Yu ◽  
Tao Han ◽  
Catherine D. Moser ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Growth Factor Signaling ◽  
Fibroblast Growth ◽  
Fibroblast Growth Factor Signaling

scholarly journals Fibroblast growth factor signaling in skeletal evolution

2008 ◽  
Vol 319 (2) ◽  
pp. 499 ◽  
Author(s):  
Nicolas Rohner ◽  
Matthew Harris ◽  
Miklós Bercsényi ◽  
Laszlo Orban ◽  
Christiane Nüsslein-Volhard
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Growth Factor Signaling ◽  
Fibroblast Growth ◽  
Fibroblast Growth Factor Signaling
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