scholarly journals Progesterone receptor gene inactivation and CpG island hypermethylation in human leukemia cancer cells

FEBS Letters ◽  
2004 ◽  
Vol 567 (2-3) ◽  
pp. 327-332 ◽  
Author(s):  
Ze-Jun Liu ◽  
Xiao-Bing Zhang ◽  
Yun Zhang ◽  
Xin Yang
Keyword(s):  
Progesterone Receptor ◽  
Cancer Cells ◽  
Cpg Island ◽  
Receptor Gene ◽  
Gene Inactivation ◽  
Human Leukemia ◽  
Progesterone Receptor Gene

Progesterone receptor (PROGINS) polymorphism and the risk of endometrial cancer development

2007 ◽  
Vol 17 (1) ◽  
pp. 229-232 ◽  
Author(s):  
M. G. Junqueira ◽  
I. D.C.G. Da Silva ◽  
N. C. Nogueira-De-Souza ◽  
C. V. Carvalho ◽  
D. B. Leite ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Progesterone Receptor ◽  
Receptor Gene ◽  
Population Based ◽  
Cancer Development ◽  
Control Group ◽  
Cancer Group ◽  
Increased Risk ◽  
Progesterone Receptor Gene ◽  
Risk Modifier

The progesterone receptor gene (PROGINS) has been identified as a risk modifier for benign and malignant gynecological diseases. The present case-control study is to evaluate the role of the PROGINS polymorphisms, as risk factor, for endometrial cancer development and to investigate the association between these genetics variants and clinical/pathologic variables of endometrial cancer. PROGINS polymorphism was examined in a total of 121 patients with endometrial cancer and 282 population-based control subjects, all located at the same area in São Paulo, SP, Brazil. The genotyping of PROGINS polymorphism was determined by polymerase chain reaction. The frequencies of PROGINS polymorphism T1/T1, T1/T2, and T2/T2 were 82.6%, 14.9%, and 2.5% in the endometrial cancer patients and 78.4%, 21.6%, and 0% in the controls, respectively. The χ2 test showed a higher incidence of the T2/T2 genotype in the endometrial cancer group subjects, these results were statistically different (P= 0.012). However, due to the fact that there were no women in the control group showing homozygosis for the allele T2, the correct evaluation of odds ratio could not be properly calculated. Regarding the clinical and pathologic findings observed within the group of patients with endometrial cancer, there was significant correlation between T1/T2 genotype and the presence of myoma (P= 0.048). No correlations were observed among the other variables. These data suggest that the PROGINS polymorphism T2/T2 genotype might be associated with an increased risk of endometrial cancer.

+331(G>A) polymorphism in progesterone receptor gene is not associated with spontaneous preterm birth

2005 ◽  
Vol 193 (6) ◽  
pp. S162
Author(s):  
Errol Norwitz ◽  
Thomas Morgan ◽  
Victoria Snegovskikh ◽  
Jessica Illuzzi ◽  
Catalin Buhimschi ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Progesterone Receptor ◽  
Receptor Gene ◽  
Spontaneous Preterm Birth ◽  
Progesterone Receptor Gene
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