Fisetin inhibits cell migration via inducing HO-1 and reducing MMPs expression in breast cancer cell lines

2018 ◽  
Vol 120 ◽  
pp. 528-535 ◽  
Author(s):  
Cheng-Fang Tsai ◽  
Jia-Hong Chen ◽  
Chen-Ni Chang ◽  
Dah-Yuu Lu ◽  
Pei-Chun Chang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Migration ◽  
Cell Lines ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cancer Cell Lines ◽  
Breast Cancer Cell Lines

scholarly journals Effects of Resveratrol in Cell Migration and Invasion by Studying the CXCR4‐CXCL12 axis in Breast Cancer Cell Lines

2018 ◽  
Vol 32 (S1) ◽  
Author(s):  
Gerardo Antonio Arroyo‐Martinez ◽  
Maria Figueroa ◽  
Kevin Muñoz‐Forti ◽  
Geralin Trossi ◽  
Jose Robles ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Migration ◽  
Cell Lines ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cancer Cell Lines ◽  
Migration And Invasion ◽  
Breast Cancer Cell Lines ◽  
Cell Migration And Invasion

184 Involvement of calpains in cell migration in different breast cancer cell lines

2015 ◽  
Vol 51 ◽  
pp. S24
Author(s):  
L. Rodríguez-Fernández ◽  
S. Oltra ◽  
I.D. Escoms ◽  
I. Vicens-Ferrer ◽  
G. Ribas ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Migration ◽  
Cell Lines ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cancer Cell Lines ◽  
Breast Cancer Cell Lines

scholarly journals Antioxydation And Cell Migration Genes Are Identified as Potential Therapeutic Targets in Basal-Like and BRCA1 Mutated Breast Cancer Cell Lines

2018 ◽  
Vol 15 (1) ◽  
pp. 46-58 ◽  
Author(s):  
Maud Privat ◽  
Justine Rudewicz ◽  
Nicolas Sonnier ◽  
Christelle Tamisier ◽  
Flora Ponelle-Chachuat ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Migration ◽  
Cell Lines ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Therapeutic Targets ◽  
Cancer Cell Lines ◽  
Breast Cancer Cell Lines

Cytotoxic activity and anti-cancer potential of Ontario grown onion extracts against breast cancer cell lines

2018 ◽  
Vol 8 (3) ◽  
pp. 159 ◽  
Author(s):  
Meghan Fragis ◽  
Abdulmonem I. Murayyan ◽  
Suresh Neethirajan
Keyword(s):  
Breast Cancer ◽  
Cytotoxic Activity ◽  
Cell Lines ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cancer Cell Lines ◽  
Breast Cancer Cell Lines ◽  
Cytotoxic Activities ◽  
Cancer Line ◽  
Mcf 7

Background: Breast cancer is the most commonly diagnosed cancer and the second leading cause of cancer deaths among Canadian women. Cancer management through changes in lifestyle, such as increased intake of foods rich in dietary flavonoids, have been shown to decrease the risk associated with breast, liver, colorectal, and upper-digestive cancers in epidemiologic studies. Onions are high in flavonoid content and one of the most common vegetables. Additionally, onions are used in most Canadian cuisines.Methods: We investigated the effect of five prominent Ontario grown onion (Stanley, Ruby Ring, LaSalle, Fortress, and Safrane) extracts on two subtypes of breast cancer cell lines: a triple negative breast cancer line MDA-MB-231 and an ER+ breast cancer line MCF-7.Results: These onion extracts elicited strong anti-proliferative, anti-migratory, and cytotoxic activities on both the cancer cell lines. Flavonoids present in these onion extracts induced apoptosis, cell cycle arrest in the G2/M phase, and a reduction in mitochondrial membrane potential at dose-dependent concentrations. Onion extracts were more effective against MDA-MB-231 compared to the MCF-7 cell line. Conclusion: In this study, we investigated the extracts synthesized from Ontario-grown onion varieties in inducing anti-migratory, cytostatic, and cytotoxic activities in two sub-types of human breast cancer cell lines. Anti-tumor activity of these extracts depends upon the varietal and can be formulated into nutraceuticals and functional foods for the wellbeing of cancer patients. Overall, the results suggest that onion extracts are a good source of flavonoids with anti-cancerous properties.Keywords: onion extracts; flavonoids; anti-proliferative; breast cancer; cytotoxic activity

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