scholarly journals Achillea millefolium L. hydroethanolic extract inhibits growth of human tumor cell lines by interfering with cell cycle and inducing apoptosis

2018 ◽  
Vol 118 ◽  
pp. 635-644 ◽  
Author(s):  
Joana M. Pereira ◽  
Vanessa Peixoto ◽  
Alexandra Teixeira ◽  
Diana Sousa ◽  
Lillian Barros ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Tumor Cell ◽  
Cell Lines ◽  
Human Tumor ◽  
Achillea Millefolium ◽  
Tumor Cell Lines ◽  
Human Tumor Cell ◽  
Human Tumor Cell Lines ◽  
Hydroethanolic Extract

Evaluation of Effect of Triterpenes and Limonoids on Cell Growth, Cell Cycle and Apoptosis in Human Tumor Cell Lines

2010 ◽  
Vol 10 (10) ◽  
pp. 769-776 ◽  
Author(s):  
Cristiane M. Cazal ◽  
Kantima Choosang ◽  
Vanessa Gisele P. Severino ◽  
Marcio S. Soares ◽  
Andre Lucio F. Sarria ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Growth ◽  
Tumor Cell ◽  
Cell Lines ◽  
Human Tumor ◽  
Tumor Cell Lines ◽  
Human Tumor Cell ◽  
Human Tumor Cell Lines

The influence of Cremophor EL on the cell cycle effects of paclitaxel (Taxol�) in human tumor cell lines

1994 ◽  
Vol 33 (4) ◽  
pp. 331-339 ◽  
Author(s):  
James Liebmann ◽  
John A. Cook ◽  
Claudia Lipschultz ◽  
Diane Teague ◽  
Joyce Fisher ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Tumor Cell ◽  
Cell Lines ◽  
Human Tumor ◽  
Tumor Cell Lines ◽  
Cremophor El ◽  
Human Tumor Cell ◽  
Human Tumor Cell Lines

scholarly journals Loratadine dysregulates cell cycle progression and enhances the effect of radiation in human tumor cell lines

2010 ◽  
Vol 5 (1) ◽  
Author(s):  
Benjamin P Soule ◽  
Nicole L Simone ◽  
William G DeGraff ◽  
Rajani Choudhuri ◽  
John A Cook ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Tumor Cell ◽  
Cell Lines ◽  
Cell Cycle Progression ◽  
Human Tumor ◽  
Tumor Cell Lines ◽  
Human Tumor Cell ◽  
Cycle Progression ◽  
Human Tumor Cell Lines

The influence of Cremophor EL on the cell cycle effects of paclitaxel (Taxol�) in human tumor cell lines

1994 ◽  
Vol 33 (4) ◽  
pp. 331-339 ◽  
Author(s):  
James Liebmann ◽  
John A. Cook ◽  
Claudia Lipschultz ◽  
Diane Teague ◽  
Joyce Fisher ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Tumor Cell ◽  
Cell Lines ◽  
Human Tumor ◽  
Tumor Cell Lines ◽  
Cremophor El ◽  
Human Tumor Cell ◽  
Human Tumor Cell Lines

Differential Increases in Glutathione S-Transferase Activities in a Range of Multidrug-Resistant Human Tumor Cell Lines

1989 ◽  
Vol 1 (6) ◽  
pp. 359-365 ◽  
Author(s):  
Richard D. H. Whelan ◽  
Louise K. Hosking ◽  
Alan J. Townsend ◽  
Kenneth H. Cowan ◽  
Bridget T. Hill
Keyword(s):  
Tumor Cell ◽  
Cell Lines ◽  
Human Tumor ◽  
Multidrug Resistant ◽  
Tumor Cell Lines ◽  
Glutathione S Transferase ◽  
Human Tumor Cell ◽  
Human Tumor Cell Lines

Synthesis and Cytotoxicity of New Mannich Bases of 6-[3-(3,4,5-Trimetoxyphenyl)-2- propenoyl]-2(3H)-Benzoxazolone

2020 ◽  
Vol 17 (4) ◽  
pp. 512-517
Author(s):  
Ognyan Ivanov Petrov ◽  
Yordanka Borisova Ivanova ◽  
Mariana Stefanova Gerova ◽  
Georgi Tsvetanov Momekov
Keyword(s):  
Tumor Cell ◽  
Cell Lines ◽  
Biological Activities ◽  
Human Tumor ◽  
Mannich Bases ◽  
In Vitro Cytotoxicity ◽  
Tumor Cell Lines ◽  
Human Tumor Cell ◽  
Human Tumor Cell Lines

Background: Chemotherapy is one of the mainstays of cancer treatment, despite the serious side effects of the clinically available anticancer drugs. In recent years increasing attention has been directed towards novel agents with improved efficacy and selectivity. Compounds with chalcone backbone have been reported to possess various biological activities such as anticancer, antimicrobial, anti-inflammatory, analgesic, antioxidant, etc. It was reported that aminomethylation of hydroxy chalcones to the corresponding Mannich bases increased their cytotoxicity. In this context, our interest has been focused on the design and synthesis of the so-called multi-target molecules, containing two or more pharmacophore fragments. Methods: A series of Mannich bases were synthesized by the reaction between 6-[3-(3,4,5- trimethoxyphenyl)-2-propenoyl]-2(3Н)-benzoxazolone, formaldehyde, and a secondary amine. The structures of the compounds were confirmed by elemental analysis, IR and NMR spectra. The new Mannich bases were evaluated for their in vitro cytotoxicity against a panel of human tumor cell lines, including BV-173, SKW-3, K-562, HL-60, HD-MY-Z and MDA-MB-231. The effects of selected compounds on the cellular levels of glutathione (GSH) were determined. Results: The new compounds 4a-e exhibited concentration-dependent cytotoxic effects at micromolar concentrations in MTT-dye reduction assay against a panel of human tumor cell lines, similar to those of starting chalcone 3. The tested agents led to concentration - dependent depletion of cellular GSH levels, whereby the effects of the chalcone prototype 3 and its Mannich base-derivatives were comparable. Conclusion: The highest chemosensitivity to the tested compounds was observed in BV- 173followed by SKW-3 and HL-60 cell lines.

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