scholarly journals A 90-day OECD TG 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects of the aerosol from the carbon heated tobacco product version 1.2 (CHTP1.2) compared with cigarette smoke. II. Systems toxicology assessment

2018 ◽  
Vol 115 ◽  
pp. 284-301 ◽  
Author(s):  
Bjoern Titz ◽  
Ulrike Kogel ◽  
Florian Martin ◽  
Walter K. Schlage ◽  
Yang Xiang ◽  
...  
Keyword(s):  
Cigarette Smoke ◽  
Tobacco Product ◽  
Inhalation Study ◽  
Systems Toxicology ◽  
Toxicology Assessment

scholarly journals Respiratory Effects of Exposure to Aerosol From the Candidate Modified-Risk Tobacco Product THS 2.2 in an 18-Month Systems Toxicology Study With A/J Mice

2020 ◽  
Vol 178 (1) ◽  
pp. 138-158
Author(s):  
Bjoern Titz ◽  
Alain Sewer ◽  
Karsta Luettich ◽  
Ee Tsin Wong ◽  
Emmanuel Guedj ◽  
...  
Keyword(s):  
Respiratory Tract ◽  
Stress Responses ◽  
Respiratory Health ◽  
Heating System ◽  
Tobacco Product ◽  
Effective Measure ◽  
Systems Toxicology ◽  
Toxicology Study ◽  
Integrative Assessment ◽  
Toxicology Assessment

Abstract Smoking cessation is the most effective measure for reducing the risk of smoking-related diseases. However, switching to less harmful products (modified-risk tobacco products [MRTP]) can be an alternative to help reduce the risk for adult smokers who would otherwise continue to smoke. In an 18-month chronic carcinogenicity/toxicity study in A/J mice (OECD Test Guideline 453), we assessed the aerosol of Tobacco Heating System 2.2 (THS 2.2), a candidate MRTP based on the heat-not-burn principle, compared with 3R4F cigarette smoke (CS). To capture toxicity- and disease-relevant mechanisms, we complemented standard toxicology endpoints with in-depth systems toxicology analyses. In this part of our publication series, we report on integrative assessment of the apical and molecular exposure effects on the respiratory tract (nose, larynx, and lungs). Across the respiratory tract, we found changes in inflammatory response following 3R4F CS exposure (eg, antimicrobial peptide response in the nose), with both shared and distinct oxidative and xenobiotic responses. Compared with 3R4F CS, THS 2.2 aerosol exerted far fewer effects on respiratory tract histology, including adaptive tissue changes in nasal and laryngeal epithelium and inflammation and emphysematous changes in the lungs. Integrative analysis of molecular changes confirmed the substantially lower impact of THS 2.2 aerosol than 3R4F CS on toxicologically and disease-relevant molecular processes such as inflammation, oxidative stress responses, and xenobiotic metabolism. In summary, this work exemplifies how apical and molecular endpoints can be combined effectively for toxicology assessment and further supports findings on the reduced respiratory health risks of THS 2.2 aerosol.

scholarly journals Systems Toxicology Assessment of the Biological Impact of a Candidate Modified Risk Tobacco Product on Human Organotypic Oral Epithelial Cultures

2016 ◽  
Vol 29 (8) ◽  
pp. 1252-1269 ◽  
Author(s):  
Filippo Zanetti ◽  
Alain Sewer ◽  
Carole Mathis ◽  
Anita R. Iskandar ◽  
Radina Kostadinova ◽  
...  
Keyword(s):  
Tobacco Product ◽  
Biological Impact ◽  
Systems Toxicology ◽  
Epithelial Cultures ◽  
Toxicology Assessment ◽  
Oral Epithelial

scholarly journals Effects of cigarette smoke, cessation and switching to a candidate modified risk tobacco product on the liver in Apoe−/− mice – a systems toxicology analysis

2016 ◽  
Vol 28 (5) ◽  
pp. 226-240 ◽  
Author(s):  
Giuseppe Lo Sasso ◽  
Bjoern Titz ◽  
Catherine Nury ◽  
Stéphanie Boué ◽  
Blaine Phillips ◽  
...  
Keyword(s):  
Cigarette Smoke ◽  
Tobacco Product ◽  
Systems Toxicology ◽  
Smoke Cessation

Systems Toxicology meta-analysis: Impact of a candidate modified-risk tobacco product aerosol compared with cigarette smoke on organotypic aerodigestive tract cultures

2017 ◽  
Vol 280 ◽  
pp. S262-S263
Author(s):  
Anita R. Iskandar ◽  
Bjoern Titz ◽  
Alain Sewer ◽  
Patrice Leroy ◽  
Thomas Schneider ◽  
...  
Keyword(s):  
Cigarette Smoke ◽  
Meta Analysis ◽  
Tobacco Product ◽  
Aerodigestive Tract ◽  
Systems Toxicology

scholarly journals Systems toxicology meta-analysis of in vitro assessment studies: biological impact of a candidate modified-risk tobacco product aerosol compared with cigarette smoke on human organotypic cultures of the aerodigestive tract

2017 ◽  
Vol 6 (5) ◽  
pp. 631-653 ◽  
Author(s):  
A. R. Iskandar ◽  
B. Titz ◽  
A. Sewer ◽  
P. Leroy ◽  
T. Schneider ◽  
...  
Keyword(s):  
Cigarette Smoke ◽  
Meta Analysis ◽  
Tobacco Product ◽  
Aerodigestive Tract ◽  
Organotypic Cultures ◽  
Biological Impact ◽  
Systems Toxicology ◽  
In Vitro Assessment

Reduced impact of a tobacco product was observed on the smoking “field-of-injury” tissues.

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