Diet with high content of advanced glycation end products induces systemic inflammation and weight gain in experimental mice: Protective role of curcumin and gallic acid

2018 ◽  
Vol 114 ◽  
pp. 237-245 ◽  
Author(s):  
Boopathi Sowndhar Rajan ◽  
Senthamizharasi Manivasagam ◽  
Suresh Dhanusu ◽  
Navvi Chandrasekar ◽  
Kalaiselvi Krishna ◽  
...  
Keyword(s):  
Weight Gain ◽  
Gallic Acid ◽  
Systemic Inflammation ◽  
Advanced Glycation End Products ◽  
Protective Role ◽  
Advanced Glycation ◽  
Glycation End Products ◽  
End Products

scholarly journals Renal Protective Role of Xiexin Decoction with Multiple Active Ingredients Involves Inhibition of Inflammation through Downregulation of the Nuclear Factor-κB Pathway in Diabetic Rats

2013 ◽  
Vol 2013 ◽  
pp. 1-15 ◽  
Author(s):  
Jia-sheng Wu ◽  
Rong Shi ◽  
Jie Zhong ◽  
Xiong Lu ◽  
Bing-liang Ma ◽  
...  
Keyword(s):  
Advanced Glycation End Products ◽  
Protective Role ◽  
Diabetic Rats ◽  
Partial Least Square ◽  
Nuclear Factor ◽  
Advanced Glycation ◽  
Advanced Glycation End Product ◽  
Glycation End Products ◽  
End Products

In Chinese medicine, Xiexin decoction (XXD) has been used for the clinical treatment of diabetes for at least 1700 years. The present study was conducted to investigate the effective ingredients of XXD and their molecular mechanisms of antidiabetic nephropathy in rats. Rats with diabetes induced by high-fat diet and streptozotocin were treated with XXD extract for 12 weeks. XXD significantly improved the glucolipid metabolism disorder, attenuated albuminuria and renal pathological changes, reduced renal advanced glycation end-products, inhibited receptor for advanced glycation end-product and inflammation factors expression, suppressed renal nuclear factor-κB pathway activity, and downregulated renal transforming growth factor-β1. The concentrations of multiple components in plasma from XXD were determined by liquid chromatography and tandem mass spectrometry. Pharmacokinetic/pharmacodynamic analysis using partial least square regression revealed that 8 ingredients of XXD were responsible for renal protective effects via actions on multiple molecular targets. Our study suggests that the renal protective role of XXD with multiple effective ingredients involves inhibition of inflammation through downregulation of the nuclear factor-κB pathway, reducing renal advanced glycation end-products and receptor for advanced glycation end-product in diabetic rats.

scholarly journals Role of advanced glycation end products in cellular signaling

Redox Biology ◽  
2014 ◽  
Vol 2 ◽  
pp. 411-429 ◽  
Author(s):  
Christiane Ott ◽  
Kathleen Jacobs ◽  
Elisa Haucke ◽  
Anne Navarrete Santos ◽  
Tilman Grune ◽  
...  
Keyword(s):  
Advanced Glycation End Products ◽  
Cellular Signaling ◽  
Advanced Glycation ◽  
Glycation End Products ◽  
End Products

The role of receptor for advanced glycation end products (RAGE) in neuronal differentiation

2012 ◽  
Vol 90 (6) ◽  
pp. 1136-1147 ◽  
Author(s):  
Joanne Kim ◽  
Carthur K. Wan ◽  
Simon J. O'Carroll ◽  
Shamim B. Shaikh ◽  
Louise F.B. Nicholson
Keyword(s):  
Neuronal Differentiation ◽  
Advanced Glycation End Products ◽  
Advanced Glycation ◽  
Glycation End Products ◽  
End Products
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