A 90-day oral toxicity study of glycolipids from Dacryopinax spathularia in Beagle dogs

2017 ◽  
Vol 109 ◽  
pp. 544-551 ◽  
Author(s):  
Jens Bitzer ◽  
Thomas Henkel ◽  
Andrey I. Nikiforov ◽  
Marisa O. Rihner ◽  
Kim A. Henderson
Keyword(s):  
Toxicity Study ◽  
Beagle Dogs ◽  
Oral Toxicity

Spontaneous Disseminated Panarteritis in Laboratory Beagle Dogs in a Toxicity Study: A Possible Genetic Predilection

1989 ◽  
Vol 17 (1_part_2) ◽  
pp. 145-152 ◽  
Author(s):  
Zadok Ruben ◽  
Paul Deslex ◽  
Gary Nash ◽  
Ninfa I. Redmond ◽  
Michel Poncet ◽  
...  
Keyword(s):  
Cellular Proliferation ◽  
The Body ◽  
Toxicity Study ◽  
Larva Migrans ◽  
Beagle Dogs ◽  
Oral Toxicity ◽  
Internal Elastic Lamina ◽  
Cellular Inflammation ◽  
Round Worm ◽  
Nuclear Cell

Disseminated panarteritis was found in 16 (9 males and 7 females) of 49 laboratory beagle dogs (25 males and 24 females) from one breeding kennel. The dogs had been used in a 6-month oral toxicity study. Panarteritis was not associated with clinical or gross abnormalities. The incidence was similar in the control and test article-treated groups. Mainly medium-sized arteries throughout the body, particularly intercostal arteries (at their aortic origin), and coronary, epididymal and thymic vessels were affected. Chronic mono-nuclear-cell periarteritis was the predominant feature. Mixed cellular inflammation of the wall, proliferation or degeneration of muscle cells, focal “fibrinoid” material in the tunica media, fragmented internal elastic lamina and intimal thickening associated with myointimal cellular proliferation also occurred. These histologic changes are compatible with those of immune arteritis. Round worm intestinal infestation and granulomas of visceral larva migrans were common in several organs. Statistical analyses suggested that the pedigree of dogs is related to panarteritis, but the presence or absence of parasitization alone is not. The possible roles of genetic predilection and/or parasites in the pathogenesis are discussed. This panarteritis is spontaneous and may complicate the interpretation of lesions in toxicity studies.

Six month oral toxicity study of trinitrotoluene in beagle dogs

Toxicology ◽  
1990 ◽  
Vol 63 (2) ◽  
pp. 233-244 ◽  
Author(s):  
B.S. Levine ◽  
J.H. Rust ◽  
J.J. Barkley ◽  
E.M. Furedi ◽  
P.M. Lish
Keyword(s):  
Toxicity Study ◽  
Beagle Dogs ◽  
Oral Toxicity

Repeated-dose 26-week oral toxicity study of ginsenoside compound K in Beagle dogs

2020 ◽  
Vol 248 ◽  
pp. 112323 ◽  
Author(s):  
Chunmei Li ◽  
Zhezhe Wang ◽  
Tong Wang ◽  
Guangfei Wang ◽  
Guisheng Li ◽  
...  
Keyword(s):  
Toxicity Study ◽  
Repeated Dose ◽  
Beagle Dogs ◽  
Compound K ◽  
Oral Toxicity ◽  
Ginsenoside Compound K

Acute and sub-chronic 90-day oral toxicity study of Perilla seed oil in rodents and Beagle dogs

2019 ◽  
Vol 103 ◽  
pp. 229-236 ◽  
Author(s):  
Hui-xing Zhang ◽  
Jian Guan ◽  
Yi-hong Tian ◽  
Guang-yue Su ◽  
Yu-qing Zhao
Keyword(s):  
Seed Oil ◽  
Toxicity Study ◽  
Beagle Dogs ◽  
Oral Toxicity ◽  
Perilla Seed

A 26-week 20(S)-ginsenoside Rg3 oral toxicity study in Beagle dogs

2020 ◽  
Vol 110 ◽  
pp. 104522 ◽  
Author(s):  
Yonglin Gao ◽  
Guangfei Wang ◽  
Tong Wang ◽  
Guisheng Li ◽  
Jian Lin ◽  
...  
Keyword(s):  
Toxicity Study ◽  
Ginsenoside Rg3 ◽  
Beagle Dogs ◽  
Oral Toxicity

scholarly journals A 90-day Repeat-Dose Oral Toxicity Study of Yonkenafil Hydrochloride in Beagle Dogs

2017 ◽  
Vol 06 (03) ◽  
Author(s):  
Chang Liu ◽  
Hongtao Jin ◽  
Baodong Yu ◽  
Jinfeng Wei ◽  
Aiping Wang
Keyword(s):  
Toxicity Study ◽  
Repeat Dose ◽  
Beagle Dogs ◽  
Oral Toxicity ◽  
Dose Oral

scholarly journals FIFTY TWO-WEEK CHRONIC ORAL TOXICITY STUDY OF MOFEZOLAC (N-22) IN BEAGLE DOGS

1990 ◽  
Vol 15 (SupplementII) ◽  
pp. 111-149 ◽  
Author(s):  
Mitsunobu OHKUBO ◽  
Toshihiro KATSUTA ◽  
Akihiko MASUNAGA ◽  
Eiichi ARAKI ◽  
Tsutomu ICHIKI ◽  
...  
Keyword(s):  
Toxicity Study ◽  
Beagle Dogs ◽  
Oral Toxicity

A subchronic oral toxicity study on medical herb extract, KIOM CRC#BP10A, in male and female mice

Planta Medica ◽  
2015 ◽  
Vol 81 (16) ◽  
Author(s):  
ES Cho ◽  
YJ Lee ◽  
JS Park ◽  
J Kim ◽  
NS Kim ◽  
...  
Keyword(s):  
Toxicity Study ◽  
Oral Toxicity ◽  
Male And Female ◽  
Female Mice ◽  
Subchronic Oral Toxicity Study ◽  
Herb Extract
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