The combined effects of developmental lead and ethanol exposure on hippocampus dependent spatial learning and memory in rats: Role of oxidative stress

2016 ◽  
Vol 96 ◽  
pp. 263-272 ◽  
Author(s):  
Elham Soleimani ◽  
Iran Goudarzi ◽  
Kataneh Abrari ◽  
Taghi Lashkarbolouki
Keyword(s):  
Oxidative Stress ◽  
Learning And Memory ◽  
Spatial Learning ◽  
Ethanol Exposure ◽  
Spatial Learning And Memory ◽  
Combined Effects

scholarly journals Nrf2 Ablation Promotes Alzheimer’s Disease-Like Pathology in APP/PS1 Transgenic Mice: The Role of Neuroinflammation and Oxidative Stress

2020 ◽  
Vol 2020 ◽  
pp. 1-13
Author(s):  
Peng Ren ◽  
Jingwei Chen ◽  
Bingxuan Li ◽  
Mengzhou Zhang ◽  
Bei Yang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Transgenic Mice ◽  
Learning And Memory ◽  
Spatial Learning ◽  
Morris Water Maze Test ◽  
Spatial Learning And Memory ◽  
Related Factor ◽  
Qrt Pcr

Introduction. Alzheimer’s disease (AD), the most common neurodegenerative disorder, is characterized by the accumulation of amyloid-β (Aβ) peptide and hyperphosphorylated tau protein. Accumulating evidence has revealed that the slow progressive deterioration of AD is associated with oxidative stress and chronic inflammation in the brain. Nuclear factor erythroid 2- (NF-E2-) related factor 2 (Nrf2), which acts through the Nrf2/ARE pathway, is a key regulator of the antioxidant and anti-inflammatory response. Although recent data show a link between Nrf2 and AD-related cognitive decline, the mechanism is still unknown. Thus, we explored how Nrf2 protects brain cells against the oxidative stress and inflammation of AD in a mouse model of AD (APP/PS1 transgenic (AT) mice) with genetic removal of Nrf2. Methods. The spatial learning and memory abilities of 12-month-old transgenic mice were evaluated using a Morris water maze test. Hippocampal levels of Nrf2, Aβ, and p-tauS404 and of astrocytes and microglia were determined by immunostaining. Inflammatory cytokines were determined by ELISA and quantitative real-time polymerase chain reaction (qRT-PCR). Oxidative stress was measured by 8-hydroxydeoxyguanosine immunohistochemistry, and the antioxidant response was determined by qRT-PCR. Results. The spatial learning and memory abilities of AT mice were impaired after Nrf2 deletion. Aβ and p-tauS404 accumulation was increased in the hippocampus of AT/Nrf2-KO mice. Astroglial and microglial activation was exacerbated, followed by upregulation of the proinflammatory cytokines IL-1β, IL-6, and TNF-α. Conclusion. Our present results show that Nrf2 deficiency aggravates AD-like pathology in AT mice. This phenotype was associated with increased levels of oxidative and proinflammatory markers, which suggests that the Nrf2 pathway may be a promising therapeutic target for AD.

The role of the central histaminergic receptors in the exercise-induced improvements of the spatial learning and memory in rats

2014 ◽  
Vol 1587 ◽  
pp. 112-118 ◽  
Author(s):  
Majid Taati ◽  
Mehrnoush Moghaddasi ◽  
Masoumeh Esmaeili ◽  
Soheila Pourkhodadad ◽  
Hassan Nayebzadeh
Keyword(s):  
Learning And Memory ◽  
Spatial Learning ◽  
Spatial Learning And Memory ◽  
Exercise Induced

Spatial learning and memory in African mole-rats: The role of sociality and sex

2009 ◽  
Vol 96 (1) ◽  
pp. 128-134 ◽  
Author(s):  
Marna S. Costanzo ◽  
Nigel C. Bennett ◽  
Heike Lutermann
Keyword(s):  
Learning And Memory ◽  
Spatial Learning ◽  
Spatial Learning And Memory

scholarly journals Role of Synaptic Structural Plasticity in Impairments of Spatial Learning and Memory Induced by Developmental Lead Exposure in Wistar Rats

PLoS ONE ◽  
2014 ◽  
Vol 9 (12) ◽  
pp. e115556 ◽  
Author(s):  
Yongmei Xiao ◽  
Hongjun Fu ◽  
Xiaojie Han ◽  
Xiaoxia Hu ◽  
Huaiyu Gu ◽  
...  
Keyword(s):  
Learning And Memory ◽  
Spatial Learning ◽  
Lead Exposure ◽  
Wistar Rats ◽  
Structural Plasticity ◽  
Spatial Learning And Memory
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