Potent inhibitory effect of alpha-viniferin on human cytochrome P450

2014 ◽  
Vol 69 ◽  
pp. 276-280 ◽  
Author(s):  
Juhee Sim ◽  
Hae Wring Jang ◽  
Min Song ◽  
Ji Hyang Kim ◽  
Seung Ho Lee ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Inhibitory Effect ◽  
Human Cytochrome ◽  
Potent Inhibitory Effect

Plant natural product plumbagin presents potent inhibitory effect on human cytochrome P450 2J2 enzyme

Phytomedicine ◽  
2018 ◽  
Vol 39 ◽  
pp. 137-145 ◽  
Author(s):  
Jian Lu ◽  
Daozhi Liu ◽  
Xiaojing Zhou ◽  
Ang Chen ◽  
Zhenran Jiang ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Natural Product ◽  
Inhibitory Effect ◽  
Human Cytochrome ◽  
Potent Inhibitory Effect

scholarly journals Chloramphenicol Is a Potent Inhibitor of Cytochrome P450 Isoforms CYP2C19 and CYP3A4 in Human Liver Microsomes

2003 ◽  
Vol 47 (11) ◽  
pp. 3464-3469 ◽  
Author(s):  
Ji-Young Park ◽  
Kyoung-Ah Kim ◽  
Su-Lyun Kim
Keyword(s):  
Cytochrome P450 ◽  
Drug Interaction ◽  
Human Liver ◽  
Liver Microsomes ◽  
Inhibitory Effect ◽  
Human Liver Microsomes ◽  
Human Cytochrome ◽  
Cytochrome P450 Isoforms ◽  
Potent Inhibitory Effect ◽  
Cyp Isoforms

ABSTRACT The inhibitory effect of chloramphenicol on human cytochrome P450 (CYP) isoforms was evaluated with human liver microsomes and cDNA-expressed CYPs. Chloramphenicol had a potent inhibitory effect on CYP2C19-catalyzed S-mephytoin 4′-hydroxylation and CYP3A4-catalyzed midazolam 1-hydroxylation, with apparent 50% inhibitory concentrations (inhibitory constant [Ki ] values are shown in parentheses) of 32.0 (7.7) and 48.1 (10.6) μM, respectively. Chloramphenicol also weakly inhibited CYP2D6, with an apparent 50% inhibitory concentration (Ki ) of 375.9 (75.8) μM. The mechanism of the drug interaction reported between chloramphenicol and phenytoin, which results in the elevation of plasma phenytoin concentrations, is clinically assumed to result from the inhibition of CYP2C9 by chloramphenicol. However, using human liver microsomes and cDNA-expressed CYPs, we showed this interaction arises from the inhibition of CYP2C19- not CYP2C9-catalyzed phenytoin metabolism. In conclusion, inhibition of CYP2C19 and CYP3A4 is the probable mechanism by which chloramphenicol decreases the clearance of coadministered drugs, which manifests as a drug interaction with chloramphenicol.

scholarly journals Inhibitory Effect of Antituberculosis Drugs on Human Cytochrome P450-Mediated Activities

2004 ◽  
Vol 96 (3) ◽  
pp. 293-300 ◽  
Author(s):  
Yuki Nishimura ◽  
Norimitsu Kurata ◽  
Eriko Sakurai ◽  
Hajime Yasuhara
Keyword(s):  
Cytochrome P450 ◽  
Inhibitory Effect ◽  
Antituberculosis Drugs ◽  
Human Cytochrome

scholarly journals Inhibitory Effect of Acacetin, Apigenin, Chrysin and Pinocembrin on Human Cytochrome P450 3A4

2020 ◽  
Vol 93 (1) ◽  
Author(s):  
Martin Kondža ◽  
Hrvoje Rimac ◽  
Željan Maleš ◽  
Petra Turčić ◽  
Ivan Ćavar ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Inhibitory Effect ◽  
Cytochrome P450 3A4 ◽  
Human Cytochrome

In vitro inhibitory effect of piperlonguminine isolated from Piper longum on human cytochrome P450 1A2

2013 ◽  
Vol 37 (8) ◽  
pp. 1063-1068 ◽  
Author(s):  
Min Song ◽  
Jae Yun Hwang ◽  
Min Young Lee ◽  
Jun-Goo Jee ◽  
You Mie Lee ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Inhibitory Effect ◽  
Cytochrome P450 1A2 ◽  
Piper Longum ◽  
Human Cytochrome

In vitro inhibitory effect of West African medicinal and food plants on human cytochrome P450 3A subfamily

2010 ◽  
Vol 128 (2) ◽  
pp. 390-394 ◽  
Author(s):  
Amegnona Agbonon ◽  
Kwashie Eklu-Gadegbeku ◽  
Kodjo Aklikokou ◽  
Messanvi Gbeassor ◽  
Koffi Akpagana ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Inhibitory Effect ◽  
West African ◽  
Food Plants ◽  
Cytochrome P450 3A ◽  
Human Cytochrome

scholarly journals The Effect of Vinpocetine on Human Cytochrome P450 Isoenzymes by Using a Cocktail Method

2016 ◽  
Vol 2016 ◽  
pp. 1-5 ◽  
Author(s):  
Lingti Kong ◽  
Chunli Song ◽  
Linhu Ye ◽  
Daohua Guo ◽  
Meiling Yu ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Ischemic Stroke ◽  
Drug Metabolism ◽  
Human Liver ◽  
Dose Adjustment ◽  
Biological Activities ◽  
Liver Microsomes ◽  
Inhibitory Effect ◽  
Inhibitory Effects ◽  
Human Cytochrome

Vinpocetine is a derivative of the alkaloid vincamine, which had been prescribed for chronic cerebral vascular ischemia and acute ischemic stroke or used as a dietary supplement for its several different mechanisms of biological activities. However, information on the cytochrome P450 (CYP) enzyme-mediated drug metabolism has not been previously studied. The present study was performed to investigate the effects of vinpocetine on CYPs activity, and cocktail method was used, respectively. To evaluate the effects of vinpocetine on the activity of human CYP3A4, CYP2C9, CYP2C19, CYP2D6, and CYP2E1, human liver microsomes were utilized to incubate with the mixed CYPs probe substrates and the target components. The results indicate that vinpocetine exhibited weak inhibitory effect on the CYP2C9, where the IC50value is 68.96 μM, whereas the IC50values for CYP3A4, CYP2C19, CYP2D6, and CYP2E1 were all over range of 100 μM, which showed that vinpocetine had no apparent inhibitory effects on these CYPs. In conclusion, the results indicated that drugs metabolized by CYP2C9 coadministrated with vinpocetine may require attention or dose adjustment.

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