Protective effect of bark and empty pod extracts from Acacia auriculiformis against paracetamol intoxicated liver injury and alloxan induced type II diabetes

2013 ◽  
Vol 56 ◽  
pp. 162-170 ◽  
Author(s):  
Arumugam Sathya ◽  
Perumal Siddhuraju
Keyword(s):  
Liver Injury ◽  
Protective Effect ◽  
Type Ii Diabetes ◽  
Acacia Auriculiformis ◽  
Type Ii

scholarly journals Pathological Consequences of Hepatic mTORC1 Dysregulation

Genes ◽  
2020 ◽  
Vol 11 (8) ◽  
pp. 896
Author(s):  
Chun-Seok Cho ◽  
Allison Ho Kowalsky ◽  
Jun Hee Lee
Keyword(s):  
Growth Factors ◽  
Liver Injury ◽  
Liver Function ◽  
Type Ii Diabetes ◽  
Liver Diseases ◽  
Mammalian Target Of Rapamycin ◽  
Type Ii ◽  
Hepatocellular Carcinogenesis ◽  
Stress Signals ◽  
Mtorc1 Activation

The mammalian target of rapamycin complex 1 (mTORC1) is a central regulator of metabolism that integrates environmental inputs, including nutrients, growth factors, and stress signals. mTORC1 activation upregulates anabolism of diverse macromolecules, such as proteins, lipids, and nucleic acids, while downregulating autolysosomal catabolism. mTORC1 dysregulation is often found in various diseases, including cancer, cardiovascular and neurodegenerative diseases, as well as metabolic syndromes involving obesity and type II diabetes. As an essential metabolic organ, the liver requires proper regulation of mTORC1 for maintaining homeostasis and preventing pathologies. For instance, aberrant hyper- or hypoactivation of mTORC1 disrupts hepatocellular homeostasis and damages the structural and functional integrity of the tissue, leading to prominent liver injury and the development of hepatocellular carcinogenesis. Proper regulation of mTORC1 during liver diseases may be beneficial for restoring liver function and ameliorating the detrimental consequences of liver failure.

A Porous Ni(II)-MOF for CO2 Cycloaddition and Protective Effect on Type-II Diabetes via Reducing Cell ROS Production and Cell Apoptosis

2019 ◽  
Vol 31 (6) ◽  
pp. 1389-1398
Author(s):  
Jie Lai ◽  
Yang Han ◽  
Hong-Mei Li ◽  
Jia Wang ◽  
Chun-Ling Wang ◽  
...  
Keyword(s):  
Protective Effect ◽  
Cell Apoptosis ◽  
Type Ii Diabetes ◽  
Ros Production ◽  
Type Ii

scholarly journals The protective effect of cannabinoid type II receptor agonist AM1241 on ConA-induced liver injury in mice via mitogen-activated protein kinase signalling pathway

2021 ◽  
Vol 35 ◽  
pp. 205873842110352
Author(s):  
Yafeng Wu ◽  
Run Ma ◽  
Cuizhen Long ◽  
Yuanhui Shu ◽  
Ping He ◽  
...  
Keyword(s):  
Liver Injury ◽  
Protective Effect ◽  
Real Time ◽  
Kupffer Cells ◽  
Immune Cells ◽  
Receptor Agonist ◽  
Enzyme Linked Immunosorbent Assay ◽  
Type Ii ◽  
Cb2 Receptor ◽  
Related Proteins

Introduction The endocannabinoid system plays an important role in regulating the immune responses in inflammation. At present, there are no good clinical drugs for many immune liver diseases. Methods We explored the protective effect of the cannabinoid type II (CB2) receptor agonist AM1241 on the liver of mice with acute liver injury caused by concanavalin from the perspective of inflammation and immunity. Pathological evaluation in hepatic tissue was examined by haematoxylin and eosin (HE) staining and the levels of biochemical parameters in the serum were measured by automatic biochemical analysis. The content of inflammatory factors was measured by enzyme-linked immunosorbent assay and real-time quantitative reverse transcription polymerase chain reaction (real-time PCR). The liver apoptosis-related proteins were observed by immunohistochemistry. The expression of liver injury-related proteins was analysed by Western blot. Immune cells were isolated from the liver of mice and studied in vitro. Results Reduced levels of alanine transaminase and aspartate transaminase were observed in ConA-induced liver injury mice treated with AM1241, together with attenuated liver damage evidenced by H&E staining. Moreover, AM1241 inhibited the protein and gene expression levels of TNF-α, IL-6 and IFN-γ in the livers of mice. The phosphorylation levels of p38, JNK, ERK1/2, P65 and cAMP response element-binding protein (CREB) in the mouse were significantly reduced in AM1241 pretreatment, while the level of p-JNK increased. In addition, the P/T-P65 and P/T-CREB of the AM1241 pretreatment group were significantly reduced. The results of immunohistochemistry measurement are consistent with those of Western blotting. The CB2-mediated effect is through macrophage-like Kupffer cells. Conclusion Our study suggests that the ConA-induced liver injury model in mice is protected by CB2 agonist AM1241 by modulation of CB2 receptor-rich immune cells, for example, Kupffer cells. Reduced inflammatory responses regulate apoptosis/cell death in the liver particularly hepatocytes and other parenchymal cells.

Protective effect of Polygonum odoratum L. on acetaminophen-induced liver injury in rats

Planta Medica ◽  
2011 ◽  
Vol 77 (12) ◽  
Author(s):  
N Somparn ◽  
S Saenthaweesuk ◽  
R Jitvaropas ◽  
A Thuppia ◽  
J Kaulpiboon
Keyword(s):  
Liver Injury ◽  
Protective Effect
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