Protective effect of cinnamon polyphenols against STZ-diabetic mice fed high-sugar, high-fat diet and its underlying mechanism

2013 ◽  
Vol 51 ◽  
pp. 419-425 ◽  
Author(s):  
Rong Li ◽  
Tao Liang ◽  
Lingyuan Xu ◽  
Yongwen Li ◽  
Shijun Zhang ◽  
...  
Keyword(s):  
Protective Effect ◽  
High Fat Diet ◽  
Underlying Mechanism ◽  
Diabetic Mice ◽  
High Fat ◽  
High Sugar

scholarly journals Wheather green tea catechins could have a protective effect in overactive bladder rats induced by high-sugar high-fat diet and ovariectomy？

2016 ◽  
Vol 27 (2) ◽  
pp. S14-S15
Author(s):  
Yi-Lun Lee ◽  
Wen-Chi Chen ◽  
Bin-Nan Wu ◽  
Shu-Mien Chuang ◽  
Wen-Jeng Wu ◽  
...  
Keyword(s):  
Overactive Bladder ◽  
Protective Effect ◽  
Green Tea ◽  
High Fat Diet ◽  
High Fat ◽  
Tea Catechins ◽  
High Sugar ◽  
Green Tea Catechins

scholarly journals Rapamycin-ameliorated diabetic symptoms involved in increasing adiponectin expression in diabetic mice on a high-fat diet

2017 ◽  
Vol 33 (7) ◽  
pp. 321-326 ◽  
Author(s):  
Fang-Hua Gong ◽  
Yan-Na Ye ◽  
Jin-Meng Li ◽  
Hai-Yang Zhao ◽  
Xiao-Kun Li
Keyword(s):  
High Fat Diet ◽  
Diabetic Mice ◽  
High Fat

Hypoglycemic effects of Auricularia auricula polysaccharides on high fat diet and streptozotocin-induced diabetic mice using metabolomics analysis

2021 ◽  
Author(s):  
nannan liu ◽  
Xuefeng Chen ◽  
Juanna Song ◽  
Mengyin Chen ◽  
Pin Gong ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
High Fat Diet ◽  
Diabetic Mice ◽  
Male Mice ◽  
High Fat ◽  
Auricularia Auricula ◽  
Ultrahigh Performance Liquid Chromatography ◽  
Metabolomic Approach ◽  
Metabolomics Analysis

This study evaluated the hypoglycemic effect of Auricularia auricula polysaccharides (AAPs) on streptozotocin-induced type 2 diabetes mellitus (T2DM) male mice (C57BL/6J) using a metabolomic approach based on ultrahigh-performance liquid chromatography–Q...

FPS-ZM1 Alleviates Circulating Indices of Liver Injury in Diet-Induced Type 2 Diabetic Mice

2022 ◽  
Author(s):  
Somayeh Aslani ◽  
Saman Bahrambeigi ◽  
Davoud Sanajou
Keyword(s):  
Liver Injury ◽  
High Fat Diet ◽  
Lifestyle Modification ◽  
Serum Levels ◽  
Diabetic Mice ◽  
High Fat ◽  
Lifestyle Modifications ◽  
Gamma Glutamyl Transpeptidase ◽  
Alcoholic Fatty Liver

Despite dietary/lifestyle modifications as well as glycemic and lipid control, non-alcoholic fatty liver disease (NAFLD) imposes a considerable risk to the patients by advancing to non-alcoholic steatohepatitis (NASH). The present investigation aims to evaluate the protective potential of FPS-ZM1, a selective inhibitor for advanced glycation end products (RAGE), against circulating indices of liver injury in high fat diet-induced diabetic mice. FPS-ZM1 at 0.5. 1, and 2 mg/kg (orally) was administered for 2 months, starting 4 months after provision of the high-fat diet. Tests for glucose homeostasis, liver injury markers, and hepatic/plasma miR-21 expressions were performed. FPS-ZM1 attenuated diabetes-induced elevations in serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), glutamate dehydrogenase (GLD), and alpha glutathione-S-transferase (α-GST) as well as alkaline phosphatase (ALP) and gamma-glutamyl transpeptidase (GGT). It also decreased diabetes-associated elevations in serum ferritin and plasma cytokeratin 18 fragments. Additionally, FPS-ZM1 down-regulated elevated expressions of miR-21 in the liver and plasma of diabetic mice. These findings highlight the benefits of FPS-ZM in alleviating liver injury in mice evoked by high-fat diet-induced type 2 diabetes and suggest FPS-ZM1 as a new potential adjunct to the conventional diet/lifestyle modification and glycemic control in diabetics.

Sign in / Sign up

Export Citation Format

Share Document