The methanolic fraction of Centratherum anthelminticum seed downregulates pro-inflammatory cytokines, oxidative stress, and hyperglycemia in STZ-nicotinamide-induced type 2 diabetic rats

2012 ◽  
Vol 50 (11) ◽  
pp. 4209-4220 ◽  
Author(s):  
Aditya Arya ◽  
Shiau Chuen Cheah ◽  
Chung Yeng Looi ◽  
Hairin Taha ◽  
Mohd. Rais Mustafa ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Inflammatory Cytokines ◽  
Diabetic Rats ◽  
Centratherum Anthelminticum ◽  
Type 2 Diabetic ◽  
Pro Inflammatory Cytokines

Activation of microglia and induction of pro-inflammatory cytokines in the hippocampus of type 2 diabetic rats

2014 ◽  
Vol 36 (9) ◽  
pp. 824-832 ◽  
Author(s):  
In Koo Hwang ◽  
Jung Hoon Choi ◽  
Sung Min Nam ◽  
Ok Kyu Park ◽  
Dae Young Yoo ◽  
...  
Keyword(s):  
Inflammatory Cytokines ◽  
Diabetic Rats ◽  
Type 2 Diabetic ◽  
Pro Inflammatory Cytokines

Arjunolic acid downregulates elevated blood sugar and pro-inflammatory cytokines in streptozotocin (STZ)-nicotinamide induced type 2 diabetic rats

Life Sciences ◽  
2021 ◽  
pp. 120232
Author(s):  
Khurram Aamir ◽  
Hidayat Ullah Khan ◽  
Chowdhury Faiz Hossain ◽  
Mst. Rejina Afrin ◽  
Patricia Regina Jusuf ◽  
...  
Keyword(s):  
Blood Sugar ◽  
Inflammatory Cytokines ◽  
Diabetic Rats ◽  
Elevated Blood ◽  
Arjunolic Acid ◽  
Type 2 Diabetic ◽  
Pro Inflammatory Cytokines

Exercise and Stevia Rebaudiana (R) Extracts Attenuate Diabetic Cardiomyopathy in Type 2 Diabetic Rats: Possible Underlying Mechanisms

2020 ◽  
Vol 20 (7) ◽  
pp. 1117-1132
Author(s):  
Abdelaziz M. Hussein ◽  
Elsayed A. Eid ◽  
Ismaeel Bin-Jaliah ◽  
Medhat Taha ◽  
Lashin S. Lashin
Keyword(s):  
Oxidative Stress ◽  
Blood Glucose ◽  
Diabetic Cardiomyopathy ◽  
Caspase 3 ◽  
Stevia Rebaudiana ◽  
Diabetic Rats ◽  
Control Group ◽  
Underlying Mechanisms ◽  
Type 2 Diabetic

Background and Aims: In the current work, we studied the effects of exercise and stevia rebaudiana (R) extracts on diabetic cardiomyopathy (DCM) in type 2 diabetic rats and their possible underlying mechanisms. Methods: : Thirty-two male Sprague Dawley rats were randomly allocated into 4 equal groups; a) normal control group, b) DM group, type 2 diabetic rats received 2 ml oral saline daily for 4 weeks, c) DM+ Exercise, type 2 diabetic rats were treated with exercise for 4 weeks and d) DM+ stevia R extracts: type 2 diabetic rats received methanolic stevia R extracts. By the end of the experiment, serum blood glucose, HOMA-IR, insulin and cardiac enzymes (LDH, CK-MB), cardiac histopathology, oxidative stress markers (MDA, GSH and CAT), myocardial fibrosis by Masson trichrome, the expression of p53, caspase-3, α-SMA and tyrosine hydroxylase (TH) by immunostaining in myocardial tissues were measured. Results: T2DM caused a significant increase in blood glucose, HOMA-IR index, serum CK-MB and LDH, myocardial damage and fibrosis, myocardial MDA, myocardial α-SMA, p53, caspase-3, Nrf2 and TH density with a significant decrease in serum insulin and myocardial GSH and CAT (p< 0.05). On the other hand, treatment with either exercise or stevia R extracts significantly improved all studied parameters (p< 0.05). Moreover, the effects of stevia R was more significant than exercise (p< 0.05). Conclusion: Both exercise and methanolic stevia R extracts showed cardioprotective effects against DCM and Stevia R offered more cardioprotective than exercise. This cardioprotective effect of these lines of treatment might be due to attenuation of oxidative stress, apoptosis, sympathetic nerve density and fibrosis and upregulation of the antioxidant transcription factor, Nrf2.

scholarly journals Author Correction: BCG and BCGΔBCG1419c protect type 2 diabetic mice against tuberculosis via different participation of T and B lymphocytes, dendritic cells and pro-inflammatory cytokines

npj Vaccines ◽  
2020 ◽  
Vol 5 (1) ◽  
Author(s):  
Cristian Alfredo Segura-Cerda ◽  
Brenda Marquina-Castillo ◽  
Vasti Lozano-Ordaz ◽  
Dulce Mata-Espinosa ◽  
Jorge Alberto Barrios-Payán ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
B Lymphocytes ◽  
Inflammatory Cytokines ◽  
T And B Lymphocytes ◽  
Diabetic Mice ◽  
Type 2 Diabetic ◽  
Pro Inflammatory Cytokines

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Acidified nitrite improves wound healing in type 2 diabetic rats: Role of oxidative stress and inflammation

Nitric Oxide ◽  
2020 ◽  
Vol 103 ◽  
pp. 20-28
Author(s):  
Hamideh Afzali ◽  
Mohammad Khaksari ◽  
Reza Norouzirad ◽  
Sajad Jeddi ◽  
Khosrow Kashfi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Wound Healing ◽  
Diabetic Rats ◽  
Type 2 Diabetic

Resveratrol Attenuates Copper and Zinc Homeostasis and Ameliorates Oxidative Stress in Type 2 Diabetic Rats

2016 ◽  
Vol 177 (1) ◽  
pp. 132-138 ◽  
Author(s):  
Soheila Asadi ◽  
Mohammad Nabi Moradi ◽  
Nejat Khyripour ◽  
Mohammad Taghi Goodarzi ◽  
Marzieh Mahmoodi
Keyword(s):  
Oxidative Stress ◽  
Diabetic Rats ◽  
Zinc Homeostasis ◽  
Copper And Zinc ◽  
Type 2 Diabetic
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