Preventive effect of grape seed extract against high-fructose diet-induced insulin resistance and oxidative stress in rats

2010 ◽  
Vol 48 (7) ◽  
pp. 1853-1857 ◽  
Author(s):  
Wannaporn Suwannaphet ◽  
Aramsri Meeprom ◽  
Sirintorn Yibchok-Anun ◽  
Sirichai Adisakwattana
Keyword(s):  
Oxidative Stress ◽  
Insulin Resistance ◽  
Grape Seed Extract ◽  
Grape Seed ◽  
Seed Extract ◽  
Preventive Effect ◽  
High Fructose Diet ◽  
High Fructose ◽  
And Oxidative Stress

scholarly journals Effect of L-Carnitine on Skeletal Muscle Lipids and Oxidative Stress in Rats Fed High-Fructose Diet

2007 ◽  
Vol 2007 ◽  
pp. 1-8 ◽  
Author(s):  
Panchamoorthy Rajasekar ◽  
Carani Venkatraman Anuradha
Keyword(s):  
Oxidative Stress ◽  
Insulin Resistance ◽  
Skeletal Muscle ◽  
Intraperitoneal Administration ◽  
Protein Carbonyls ◽  
Sensitivity Index ◽  
Rat Tissues ◽  
High Fructose Diet ◽  
High Fructose ◽  
And Oxidative Stress

There is evidence that high-fructose diet induces insulin resistance, alterations in lipid metabolism, and oxidative stress in rat tissues. The purpose of this study was to evaluate the effect of L-carnitine (CAR) on lipid accumulation and peroxidative damage in skeletal muscle of rats fed high-fructose diet. Fructose-fed animals (60 g/100 g diet) displayed decreased glucose/insulin (G/I) ratio and insulin sensitivity index (ISI0,120) indicating the development of insulin resistance. Rats showed alterations in the levels of triglycerides, free fatty acids, cholesterol, and phospholipids in skeletal muscle. The condition was associated with oxidative stress as evidenced by the accumulation of lipid peroxidation products, protein carbonyls, and aldehydes along with depletion of both enzymic and nonenzymic antioxidants. Simultaneous intraperitoneal administration of CAR (300 mg/kg/day) to fructose-fed rats alleviated the effects of fructose. These rats showed near-normal levels of the parameters studied. The effects of CAR in this model suggest that CAR supplementation may have some benefits in patients suffering from insulin resistance.

scholarly journals Pre-Treatment with Grape Seed Extract Reduces Inflammatory Response and Oxidative Stress Induced by Helicobacter pylori Infection in Human Gastric Epithelial Cells

Antioxidants ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 943
Author(s):  
Jose Manuel Silvan ◽  
Alba Gutierrez-Docio ◽  
Esperanza Guerrero-Hurtado ◽  
Lucia Domingo-Serrano ◽  
Ana Blanco-Suarez ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Helicobacter Pylori ◽  
Epithelial Cells ◽  
Grape Seed Extract ◽  
Grape Seed ◽  
Seed Extract ◽  
Gastric Epithelial Cells ◽  
Pre Treatment ◽  
H Pylori ◽  
And Oxidative Stress

Helicobacter pylori (H. pylori) is a pathogenic bacteria identified as a potential risk factor for gastritis, gastric ulcers and gastric cancer. During the stomach colonization, H. pylori triggers a strong inflammatory response and subsequent oxidative stress, which are associated with tissue damage. For this reason, it is of particular interest to develop alternative natural tools that enable modulation of the associated damaging immune response. With this purpose, we obtained grape seed extract (GSE) from sweet (not fermented) food grade seeds. The aim of our study was to investigate the effect of GSE and its two enriched procyanidins fractions (OPC and PPC) on the inflammatory process and oxidative stress produced by different H. pylori strains in human gastric epithelial cells (AGS). Anti-inflammatory activity was evaluated by measuring the level of interleukin-8 (IL-8) secretion. IL-8 production was significantly reduced in H. pylori-infected human gastric epithelial cells pre-treated with GSE or its enriched fractions when compared with non-pre-treated infected cells (from 21.6% to 87.8%). Pre-treatment with GSE or its fractions significantly decreased intracellular reactive oxygen species (ROS) production in AGS cells after infection, depending on the H. pylori strain. Our results also showed that GSE and its fractions demonstrate antibacterial activity against all strains of H. pylori used in the study. This work demonstrates the effectiveness of GSE enriched in procyanidins against the main events associated with H. pylori infection.

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