scholarly journals Effect of silymarin on biochemical parameters of oxidative stress in aged and young rat brain

2009 ◽  
Vol 47 (10) ◽  
pp. 2655-2660 ◽  
Author(s):  
F. Galhardi ◽  
K. Mesquita ◽  
J.M. Monserrat ◽  
D.M. Barros
Keyword(s):  
Oxidative Stress ◽  
Rat Brain ◽  
Biochemical Parameters ◽  
Young Rat

Methylphenidate treatment induces oxidative stress in young rat brain

2006 ◽  
Vol 1078 (1) ◽  
pp. 189-197 ◽  
Author(s):  
Márcio R. Martins ◽  
Adalisa Reinke ◽  
Fabrícia C. Petronilho ◽  
Karin M. Gomes ◽  
Felipe Dal-Pizzol ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Rat Brain ◽  
Young Rat

Gender differences in biochemical measurement reflecting the state of free-radical oxidation and antioxidant protection among workers in metallurgical production

2019 ◽  
Vol 1 (10) ◽  
pp. 877-881
Author(s):  
I. A. Umnyagina ◽  
L. A. Strakhova ◽  
T. V. Blinova
Keyword(s):  
Oxidative Stress ◽  
Gender Differences ◽  
Free Radical ◽  
Biochemical Parameters ◽  
Free Radical Oxidation ◽  
The Body ◽  
Antioxidant Protection ◽  
Radical Oxidation ◽  
Metallurgical Production ◽  
Production Factors

Introduction. To date, age and sex differences have been established for many biochemical parameters. Gender differences in indicators for systems such as antioxidant, thiol-disulfide, oxidative stress and inflammation systems are absent or under study.The aim of the study was to identify gender differences in biochemical parameters reflecting the functioning of antioxidant systems of the body and free radical oxidation in workers of metallurgical production, in contact with harmful production factors.Materials and methods. The blood of men and women working at the metallurgical enterprise of the Nizhny Novgorod region (n=80) under the influence of a complex of physical and chemical production factors was studied. Total oxidative stress, total antioxidant capacity of serum, glutathione levels were studied by photometric biochemical methods. Levels of C-reactive protein and 8-hydroxy–2-deoxyguanosine were studied by ELISA.Results. The average amount of peroxides in the serum of women exceeded 1.6 times this figure in men. In the group of men, the content of 8-Ondg was higher by 26% (p=0.012), the level of GS-by 12% (p=0.019), the activity of SOD — by 1.5–2 times (p=0.0001), the level of CRP — by 2 times (p=0.008) compared to similar indicators in women.Conclusions. Studies of gender differences in workers under the influence of harmful production factors will allow more effective approach to the etiology, treatment and prognosis of production-related diseases. Indicators of oxidative stress and antioxidant protection can be indicators of the health of workers under the influence of harmful industrial factors and be important in the prevention of diseases associated with oxidative stress.

Oleic Acid Protects Against Oxidative Stress Exacerbated by Cytarabine and Doxorubicin in Rat Brain

2016 ◽  
Vol 16 (11) ◽  
pp. 1491-1495 ◽  
Author(s):  
David Calderón Guzmán ◽  
Norma Osnaya Brizuela ◽  
Maribel Ortíz Herrera ◽  
Hugo Juárez Olguín ◽  
Ernestina Hernández García ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Oleic Acid ◽  
Rat Brain

Eudragit L-100 Capsules Aromatize and Quaternerize Chitosan for Insulin Nanoparticle Oral Delivery During Toxic Oxidative Stress in Rat Liver and Kidney

2020 ◽  
Vol 8 (3) ◽  
pp. 239-254 ◽  
Author(s):  
Reza Mahjub ◽  
Farzane K. Najafabadi ◽  
Narges Dehkhodaei ◽  
Nejat Kheiripour ◽  
Amir N. Ahmadabadi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Oral Administration ◽  
Oral Delivery ◽  
Biochemical Parameters ◽  
Kidney Injury ◽  
Regular Insulin ◽  
Treated Group ◽  
Histopathological Change ◽  
Diabetic Rats ◽  
Liver And Kidney

Background: Insulin, like most peptides, is classified as a hydrophilic and macromolecular drug that is considered as a low permeable and unstable compound in the gastrointestinal (GI) tract. The acidic condition of the stomach can degrade insulin molecules. Moreover, the presence of proteolytic activities of some enzymes such as trypsin and chymotrypsin can hydrolyze amide-bonds between various amino-acids in the structures of peptides and proteins. However, due to its simplicity and high patient compliance, oral administration is the most preferred route of systemic drug delivery, and for the development of an oral delivery system, some obstacles in oral administration of peptides and proteins including low permeability and low stability of the proteins in GI should be overcome. Objective: In this study, the effects of orally insulin nanoparticles (INPs) prepared from quaternerized N-aryl derivatives of chitosan on the biochemical factors of the liver in diabetic rats were studied. Methods: INPs composed of methylated (amino benzyl) chitosan were prepared by the PEC method. Lyophilized INPs were filled in pre-clinical capsules, and the capsules were enteric-coated with Eudragit L100. Twenty Male Wistar rats were randomly divided into four groups: group1: normal control rats, group 2: diabetic rats, group 3: diabetic rats received capsules INPs(30 U/kg/day, orally), group 4: the diabetic rats received regular insulin (5 U/kg/day, subcutaneously). At the end of the treatment, serum, liver and kidney tissues were collected. Biochemical parameters in serum were measured using spectrophotometric methods. Also, oxidative stress was measured in plasma, liver and kidney. Histological studies were performed using H and E staining . Results: Biochemical parameters, and liver and kidney injury markers in serum of the diabetic rats that received INPs improved significantly compared with the diabetic group. INPs reduced oxidative toxic stress biomarkers in serum, liver and kidney of the diabetic treated group. Furthermore, a histopathological change was developed in the treated groups. Conclusion: Capsulated INPs can prevent diabetic liver and oxidative kidney damages (similar regular insulin). Therefore oral administration of INPs appears to be safe. Lay Summary: Although oral route is the most preferred route of administration, but oral delivery of peptides and proteins is still a challenging issue. Diabetes Mellitus may lead to severe complications, which most of them are life-threatening. In this study, we are testing the toxicity of oral insulin nanoparticles in kidney and liver of rats. For this investigation, we will prepare insulin nanoparticles composed of a quaternized derivative of chitosan. The nanoparticles will be administered orally to rats and the level of oxidative stress in their liver and kidney will be determined. The data will be compared to the subcutaneous injection of insulin.

scholarly journals The oral administration of silver nanoparticles activates the kynurenine pathway in rat brain independently of oxidative stress

2019 ◽  
Vol 302 ◽  
pp. 22-27 ◽  
Author(s):  
Oluyomi Stephen Adeyemi ◽  
Rhoda Ananu Uloko ◽  
Oluwakemi Josephine Awakan ◽  
Anne Adebukola Adeyanju ◽  
David Adeiza Otohinoyi
Keyword(s):  
Oxidative Stress ◽  
Silver Nanoparticles ◽  
Oral Administration ◽  
Rat Brain ◽  
Kynurenine Pathway

D-serine treatment induces oxidative stress in rat brain

2011 ◽  
Vol 34 (2) ◽  
pp. 129-138 ◽  
Author(s):  
Guliz Armagan ◽  
Lutfiye Kanıt ◽  
Ayfer Yalcin
Keyword(s):  
Oxidative Stress ◽  
Rat Brain

scholarly journals Oxidative Stress Induces Dephosphorylation of τ in Rat Brain Primary Neuronal Cultures

2002 ◽  
Vol 68 (4) ◽  
pp. 1590-1597 ◽  
Author(s):  
Daniel R. Davis ◽  
Brian H. Anderton ◽  
Jean-Pierre Brion ◽  
C. Hugh Reynolds ◽  
Diane P. Hanger
Keyword(s):  
Oxidative Stress ◽  
Rat Brain ◽  
Neuronal Cultures ◽  
Primary Neuronal Cultures

Effects of Manganese (Mn) on the Developing Rat Brain: Oxidative-Stress Related Endpoints

2002 ◽  
Vol 23 (2) ◽  
pp. 169-175 ◽  
Author(s):  
Sarah Weber ◽  
David C. Dorman ◽  
Lawrence H. Lash ◽  
Keith Erikson ◽  
Kent E. Vrana ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Rat Brain ◽  
Brain Oxidative Stress ◽  
Developing Rat
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