Effects of organophosphorus pesticides and their ozonation byproducts on gap junctional intercellular communication in rat liver cell line

2007 ◽  
Vol 45 (10) ◽  
pp. 2057-2063 ◽  
Author(s):  
Jiguo Wu ◽  
Li Lin ◽  
Tiangang Luan ◽  
Yuk Sing Chan Gilbert ◽  
Chongyu Lan
Keyword(s):  
Cell Line ◽  
Rat Liver ◽  
Liver Cell ◽  
Intercellular Communication ◽  
Organophosphorus Pesticides ◽  
Gap Junctional Intercellular Communication ◽  
Liver Cell Line ◽  
Gap Junctional

scholarly journals Cannabinoids inhibit gap junctional intercellular communication and activate ERK in a rat liver epithelial cell line

2003 ◽  
Vol 104 (1) ◽  
pp. 12-18 ◽  
Author(s):  
Brad L. Upham ◽  
Alisa M. Rummel ◽  
Joseph M. Carbone ◽  
James E. Trosko ◽  
Yanli Ouyang ◽  
...  
Keyword(s):  
Epithelial Cell ◽  
Cell Line ◽  
Rat Liver ◽  
Intercellular Communication ◽  
Epithelial Cell Line ◽  
Gap Junctional Intercellular Communication ◽  
Gap Junctional

Doxorubicin induces EGF receptor-dependent downregulation of gap junctional intercellular communication in rat liver epithelial cells

2005 ◽  
Vol 386 (3) ◽  
pp. 217-223 ◽  
Author(s):  
Kotb Abdelmohsen ◽  
Claudia von Montfort ◽  
Dominik Stuhlmann ◽  
P. Arne Gerber ◽  
Ulrich K.M. Decking ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Rat Liver ◽  
Intercellular Communication ◽  
Connexin 43 ◽  
Egf Receptor ◽  
Gap Junctional Intercellular Communication ◽  
Erk Activation ◽  
Liver Epithelial Cells ◽  
Rat Liver Epithelial Cells ◽  
Gap Junctional

Abstract Exposure of rat liver epithelial cells to doxorubicin, an anthraquinone derivative widely employed in cancer chemotherapy, led to a dose-dependent decrease in gap junctional intercellular communication (GJC). Gap junctions are clusters of inter-cellular channels consisting of connexins, the major connexin in the cells used being connexin-43 (Cx43). Doxorubicin-induced loss of GJC was mediated by activation of extracellular signal-regulated kinase (ERK)-1 and ERK-2, as demonstrated using inhibitors of ERK activation. Furthermore, activation of the epidermal growth factor (EGF) receptor by doxorubicin was responsible for ERK activation and the subsequent attenuation of GJC. Inhibition of GJC, however, was not by direct phosphorylation of Cx43 by ERK-1/2, whereas menadione, a 1,4-naphthoquinone derivative that was previously demonstrated to activate the same EGF receptor-dependent pathway as doxorubicin, resulting in downregulation of GJC, caused strong phos-phorylation of Cx43 at serines 279 and 282. Thus, ERK-dependent downregulation of GJC upon exposure to quinones may occur both by direct phosphorylation of Cx43 and in a phosphorylation-independent manner.

scholarly journals Pancreatic Transdifferentiation and Glucose-Regulated Production of Human Insulin in the H4IIE Rat Liver Cell Line

2016 ◽  
Vol 17 (4) ◽  
pp. 534 ◽  
Author(s):  
Binhai Ren ◽  
Chang Tao ◽  
Margaret Swan ◽  
Nichole Joachim ◽  
Rosetta Martiniello-Wilks ◽  
...  
Keyword(s):  
Cell Line ◽  
Human Insulin ◽  
Rat Liver ◽  
Liver Cell ◽  
Liver Cell Line

Multiplication stimulating activity (MSA) from the BRL 3A rat liver cell line: Relation to human somatomedins and insulin

1981 ◽  
Vol 15 (3) ◽  
pp. 253-286 ◽  
Author(s):  
Matthew M. Rechler ◽  
S. Peter Nissley ◽  
George L. King ◽  
Alan C. Moses ◽  
Ellen E. Van Obberghen-Schilling ◽  
...  
Keyword(s):  
Cell Line ◽  
Rat Liver ◽  
Liver Cell ◽  
Liver Cell Line
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