Effects of glycolic acid on the induction of apoptosis via caspase-3 activation in human leukemia cell line (HL-60)

2004 ◽  
Vol 42 (11) ◽  
pp. 1777-1784 ◽  
Author(s):  
Jen-Hung Yang ◽  
Chi-Chung Chou ◽  
Ya-Wen Cheng ◽  
Lee-Yan Sheen ◽  
Ming-Chi Chou ◽  
...  
Keyword(s):  
Cell Line ◽  
Glycolic Acid ◽  
Caspase 3 ◽  
Leukemia Cell ◽  
Leukemia Cell Line ◽  
Human Leukemia ◽  
Human Leukemia Cell ◽  
Human Leukemia Cell Line ◽  
Induction Of Apoptosis

Induction of Apoptosis by KI0477959 through Activation of Caspase-3 in Human Leukemia Cell Line, HL-60 Cells

2008 ◽  
Vol 118 (10) ◽  
pp. 1384-1399 ◽  
Author(s):  
Hyun-Ja Jeong ◽  
Ju-Young Lee ◽  
Joon-Bae Kim ◽  
Hoyeon Go ◽  
Seong-Gyu Ko ◽  
...  
Keyword(s):  
Cell Line ◽  
Caspase 3 ◽  
Leukemia Cell ◽  
Leukemia Cell Line ◽  
Human Leukemia ◽  
Human Leukemia Cell ◽  
Human Leukemia Cell Line ◽  
Induction Of Apoptosis

Apoptotic Effects of a Thioether Analog of Vitamin K3 in a Human Leukemia Cell Line

2021 ◽  
pp. 109158182110479
Author(s):  
Satoru Asami ◽  
Mikana Suzuki ◽  
Toshimitsu Nakayama ◽  
Yasuyo Shimoda ◽  
Motofumi Miura ◽  
...  
Keyword(s):  
Dna Damage ◽  
Cell Line ◽  
Vitamin K ◽  
Caspase 3 ◽  
Leukemia Cell ◽  
Leukemia Cell Line ◽  
Human Leukemia ◽  
Potent Inducer ◽  
Human Leukemia Cell ◽  
Human Leukemia Cell Line

Research suggests that thioether analogs of vitamin K3 (VK3) can act to preserve the phosphorylation of epidermal growth factor receptors by blocking enzymes (phosphatases) responsible for their dephosphorylation. Additionally, these derivatives can induce apoptosis via mitogen-activated protein kinase and caspase-3 activation, inducing reactive oxygen species (ROS) production, and apoptosis. However, vitamin K1 exhibits only weak inhibition of phosphatase activity, while the ability of VK3 to cause oxidative DNA damage has raised concerns about carcinogenicity. Hence, in the current study, we designed, synthesized, and screened a number of VK3 analogs for their ability to enhance phosphorylation activity, without inducing off-target effects, such as DNA damage. 3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide (MTT) assay revealed that each analog produced a different level of cytotoxicity in the Jurkat human leukemia cell line; however, none elicited a cytotoxic effect that differed significantly from that of the control. Of the VK3 analogs, CPD5 exhibited the lowest EC50, and flow cytometry results showed that apoptosis was induced at final concentrations of ≥10 μM; hence, only 0.1, 1, and 10 μM were evaluated in subsequent assays. Furthermore, CPD5 did not cause vitamin K-attributed ROS generation and was found to be associated with a significant increase in caspase 3 expression, indicating that, of the synthesized thioether VK3 analogs, CPD5 was a more potent inducer of apoptosis than VK3. Hence, further elucidation of the apoptosis-inducing effect of CPD5 may reveal its efficacy in other neoplastic cells and its potential as a medication.

scholarly journals 2-Chloro-2′-deoxyadenosine induces apoptosis through the Fas/Fas ligand pathway in human leukemia cell line MOLT-4

Leukemia ◽  
2000 ◽  
Vol 14 (2) ◽  
pp. 299-306 ◽  
Author(s):  
Y Nomura ◽  
O Inanami ◽  
K Takahashi ◽  
A Matsuda ◽  
M Kuwabara
Keyword(s):  
Cell Line ◽  
Fas Ligand ◽  
Leukemia Cell ◽  
Leukemia Cell Line ◽  
Human Leukemia ◽  
Human Leukemia Cell ◽  
Human Leukemia Cell Line

Production of high levels of interleukin 1-like activity by the SPI-802 human leukemia cell line with E receptors

1984 ◽  
Vol 89 (1) ◽  
pp. 122-131 ◽  
Author(s):  
Atsushi Komiyama ◽  
Yukiaki Miyagawa ◽  
Kohki Aoyama ◽  
Taro Akabane ◽  
Yoshio Uehara
Keyword(s):  
Cell Line ◽  
Interleukin 1 ◽  
Leukemia Cell ◽  
Leukemia Cell Line ◽  
Human Leukemia ◽  
Human Leukemia Cell ◽  
Human Leukemia Cell Line

Vincristine-Resistant Human Leukemia Cell Line: New Monoclonal Antibodies to a 65kDa Membrane Protein

1992 ◽  
Vol 7 (1-2) ◽  
pp. 157-164 ◽  
Author(s):  
Toshio Kakihara ◽  
Toshiyuki Yamada ◽  
Takeaki Fukuda ◽  
Yoshihisa Ohnishi ◽  
Kenji Kishi ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Membrane Protein ◽  
Cell Line ◽  
Leukemia Cell ◽  
Leukemia Cell Line ◽  
Human Leukemia ◽  
Human Leukemia Cell ◽  
Human Leukemia Cell Line
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