Recombinant human platelet-derived growth factor-BB versus autologous bone graft in foot and ankle fusion: A systematic review and meta-analysis

2017 ◽  
Vol 23 (1) ◽  
pp. 32-39 ◽  
Author(s):  
Han Sun ◽  
Pei-Pei Lu ◽  
Ping-Hui Zhou ◽  
Si-Wei Sun ◽  
Hong-Tao Zhang ◽  
...  
Keyword(s):  
Systematic Review ◽  
Growth Factor ◽  
Bone Graft ◽  
Human Platelet ◽  
Meta Analysis ◽  
Autologous Bone Graft ◽  
Platelet Derived Growth Factor ◽  
Foot And Ankle ◽  
Ankle Fusion ◽  
Autologous Bone

Prospective, Randomized, Multi-Center Feasibility Trial of rhPDGF-BB versus Autologous Bone Graft in a Foot and Ankle Fusion Model

2011 ◽  
Vol 32 (4) ◽  
pp. 344-354 ◽  
Author(s):  
Christopher W. DiGiovanni ◽  
Judith Baumhauer ◽  
Sheldon S. Lin ◽  
Wayne S. Berberian ◽  
Adolph S. Flemister ◽  
...  
Keyword(s):  
Bone Graft ◽  
Autologous Bone Graft ◽  
Feasibility Trial ◽  
Foot And Ankle ◽  
Fusion Model ◽  
Ankle Fusion ◽  
Autologous Bone

scholarly journals Autologous bone graft in the treatment of post-traumatic bone defects: a systematic review and meta-analysis

2016 ◽  
Vol 17 (1) ◽  
Author(s):  
Matheus Lemos Azi ◽  
Alessandro Aprato ◽  
Irene Santi ◽  
Mauricio Kfuri ◽  
Alessandro Masse ◽  
...  
Keyword(s):  
Systematic Review ◽  
Bone Graft ◽  
Meta Analysis ◽  
Bone Defects ◽  
Autologous Bone Graft ◽  
Post Traumatic ◽  
Autologous Bone

The Combination of Purified Recombinant Human Platelet-Derived Growth Factor-BB and Equine Particulate Bone Graft for Periodontal Regeneration

2012 ◽  
Vol 83 (5) ◽  
pp. 565-573 ◽  
Author(s):  
Myron Nevins ◽  
Marc L. Nevins ◽  
Nadeem Karimbux ◽  
Soo-Woo Kim ◽  
Peter Schupbach ◽  
...  
Keyword(s):  
Growth Factor ◽  
Bone Graft ◽  
Human Platelet ◽  
Periodontal Regeneration ◽  
Platelet Derived Growth Factor

Local Bone Graft Harvested From the Distal Tibia or Calcaneus for Surgery of the Foot and Ankle

2005 ◽  
Vol 26 (6) ◽  
pp. 449-453 ◽  
Author(s):  
Steven M. Raikin ◽  
Kenneth Brislin
Keyword(s):  
Bone Graft ◽  
Iliac Crest ◽  
Distal Tibia ◽  
Autologous Bone Graft ◽  
Operative Procedures ◽  
Iliac Crest Bone Graft ◽  
Foot And Ankle ◽  
Graft Harvest ◽  
Local Bone ◽  
Autologous Bone

Background: Numerous operative procedures around the foot and ankle use bone graft to augment healing. Autologous bone graft remains the preferred type for these procedures. This can be harvested from the iliac crest, but complications are frequent. The purpose of our study was to investigate the option of harvesting the bone graft from the ipsilateral distal tibia or calcaneus. Method: Bone graft was harvested in 114 patients from the distal tibia (70 patients) or calcaneus (44 patients). The patients were followed postoperatively for an average of 16 (range 5 to 28) months and were evaluated for complications (minor and major), satisfaction, and healing rates. Results: There were no major complications. Ten patients (8.7%) had minor complications including initial incisional sensitivity or local numbness, none of which affected function or required additional treatment. Satisfaction rate for the procedure was 100%. Conclusion: Use of autologous bone graft harvested from the ipsilateral distal tibia or calcaneus is a safe and reliable alternative to iliac crest bone graft harvest for operative procedures of the foot and ankle.

scholarly journals Safety of recombinant human platelet-derived growth factor-BB in Augment®Bone Graft

2012 ◽  
Vol 3 (1) ◽  
pp. 204173141244266 ◽  
Author(s):  
Luis A Solchaga ◽  
Christopher K Hee ◽  
Stephen Roach ◽  
Leo B Snel
Keyword(s):  
Growth Factor ◽  
Bone Graft ◽  
Human Platelet ◽  
Platelet Derived Growth Factor

Autologous Bone Graft in Foot and Ankle Surgery

2016 ◽  
Vol 21 (4) ◽  
pp. 825-837 ◽  
Author(s):  
Christopher P. Miller ◽  
Christopher P. Chiodo
Keyword(s):  
Bone Graft ◽  
Autologous Bone Graft ◽  
Foot And Ankle ◽  
Ankle Surgery ◽  
Autologous Bone

scholarly journals Recombinant Human Platelet–Derived Growth Factor: A Systematic Review of Clinical Findings in Oral Regenerative Procedures

2020 ◽  
pp. 238008442092135 ◽  
Author(s):  
L. Tavelli ◽  
A. Ravidà ◽  
S. Barootchi ◽  
L. Chambrone ◽  
W.V. Giannobile
Keyword(s):  
Systematic Review ◽  
Growth Factor ◽  
Bone Regeneration ◽  
Clinical Benefit ◽  
Human Platelet ◽  
Gingival Recession ◽  
Platelet Derived Growth Factor ◽  
Ridge Preservation ◽  
Alveolar Ridge ◽  
Alveolar Ridge Preservation

Aim: The use of recombinant human platelet-derived growth factor–BB (rhPDGF) has received Food and Drug Administration approval for the treatment of periodontal and orthopedic bone defects and dermal wound healing. Many studies have investigated its regenerative potential in a variety of other oral clinical indications. The aim of this systematic review was to assess the efficacy, safety, and clinical benefit of recombinant human platelet-derived growth factor (rhPDGF) use for alveolar bone and/or soft tissue regeneration. Material and Methods: Comprehensive electronic and manual literature searches according to the PRISMA guidelines were performed to identify interventional and observational studies evaluating the regenerative applications of rhPDGF-BB. The primary outcomes were the safety, efficacy, and overall clinical benefit of rhPDGF use in oral regenerative procedures. Results: Sixty-three human clinical studies (mean ± SD follow-up period of 10.7 ± 3.3 mo) were included in the qualitative analysis. No serious adverse effects were reported in any of the 63 studies, aside from the postoperative complications routinely associated with surgical therapy. Use of rhPDGF was shown to be beneficial when combined with allografts, xenografts, and alloplasts (the latter tricalcium phosphate [β-TCP]) for the treatment of periodontal defects and gingival recession. The use of rhPDGF also led to favorable clinical outcomes when combined with allografts or xenografts for guided bone regeneration (GBR) and alveolar ridge preservation. While favorable clinical results support the use of the combination of rhPDGF plus allograft or xenograft for GBR, ARP, and sinus floor augmentation, current data support the use of rhPDGF and alloplasts (e.g., β-TCP) only in periodontal defects and gingival recession. Conclusions: Based on the clinical evidence, rhPDGF is safe and provides clinical benefits when used in combination with bone allografts, xenograft, or β-TCP for the treatment of intrabony and furcation periodontal defects and gingival recession or when used with allografts or xenograft for GBR and ARP (PROSPERO CRD42020142446). Knowledge Transfer Statement: Clinicians should be aware that rhPDGF is a safe and effective approach for the treatment of intrabony and furcation periodontal defects and gingival recession or when used with allografts or xenograft for bone regeneration and alveolar ridge preservation. With consideration of cost and patient preference, this result could lead to more appropriate therapeutic decisions.

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