The splice factor PTBP1 regulates hematopoietic stem cell function and red blood cell development

2016 ◽  
Vol 44 (9) ◽  
pp. S95-S96
Author(s):  
Matilda Rehn ◽  
Anne-Katrine Frank ◽  
Sachin Pundhir ◽  
Nicolas Rapin ◽  
Ying Ge ◽  
...  
Keyword(s):  
Stem Cell ◽  
Blood Cell ◽  
Hematopoietic Stem Cell ◽  
Red Blood Cell ◽  
Cell Function ◽  
Cell Development ◽  
Splice Factor ◽  
Hematopoietic Stem

scholarly journals Steady-state and regenerative hematopoiesis occurs normally in mice in the absence of GDF11

Blood ◽  
2019 ◽  
Vol 134 (20) ◽  
pp. 1712-1716 ◽  
Author(s):  
Jill M. Goldstein ◽  
Hilal Sengul ◽  
Kathleen A. Messemer ◽  
Marcos Fernández-Alfara ◽  
Jessica C. Garbern ◽  
...  
Keyword(s):  
Stem Cell ◽  
Steady State ◽  
Blood Cell ◽  
Hematopoietic Stem Cell ◽  
Red Blood Cell ◽  
Cell Function ◽  
Cell Formation ◽  
Hematopoietic Stem ◽  
Key Points ◽  
Genetic Deletion

Key Points Genetic deletion of Gdf11 does not affect red blood cell formation during homeostasis or after transplant. Hematopoietic stem cell function is preserved in mice lacking Gdf11 expression within the blood lineage.

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