Cross-sectional and longitudinal associations between serum 25‑hydroxyvitamin D and anti-oxidative status in older adults

2018 ◽  
Vol 110 ◽  
pp. 291-297
Author(s):  
Alexandra Jungert ◽  
Monika Neuhäuser-Berthold
Keyword(s):  
Older Adults ◽  
Oxidative Status ◽  
Cross Sectional ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Longitudinal Associations

scholarly journals SERUM 25-HYDROXYVITAMIN D LEVELS IMPACT RISK OF EXTENSIVE ASSISTANCE NEEDED BY OLDER ADULTS TO WALK

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S470-S470
Author(s):  
Krista N Jenney ◽  
Ronna Robbins ◽  
Sara Sweitzer ◽  
Nalini Ranjit ◽  
Margaret Briley
Keyword(s):  
Older Adults ◽  
Serum Levels ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Term Care ◽  
Data Set ◽  
Study Objective ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Double Blinded

Abstract Study objective is to determine the association between deficient 25-hydroxyvitamin D [25(OH)D] serum levels and the amount of assistance needed to walk in a room by older adults living in long-term care (LTC) communities. Participants (age ≥ 65) from five LTC communities in Central Texas were recruited for a multi-site, cross-sectional study (n=169). Double-blinded data abstraction protocols were used to collect a one-year medical history. Laboratory blood draws measured serum 25(OH)D levels. Level of assistance was measured by the activities of daily living score for walking in room from section G of the Minimum Data Set (MDS). To determine the association between deficient 25(OH)D serum levels (≤20 ng/ml) and assistance with walking, adjusted logistic regression was used. Total vitamin D per day (supplementation and meals), therapy and/or restorative programs, body mass index, race, gender, age, and years living in the community were used as confounders. Of the 169 participants (mean age=83) 27.17% had deficient serum 25(OH)D and 9.25% required extensive assistance to walk in a room. The mean serum level and supplementation rate of participants was 32.61 ng/ml and 1,160.64 IU per/d, respectively. Participants with deficient 25(OH)D serum levels had significantly elevated odds (OR=8.73; CL: 1.28, 8.54; p=0.027) of requiring extensive assistance to walk in a room compared to those with adequate serum levels (>20 ng/ml). Deficient 25(OH)D serum levels are associated with increased assistance to walk in a room indicating that adequate serum levels in LTC residents could potentially decrease burden on staff.

Abstract P424: Prospective Associations of Serum 25-hydroxyvitamin D and Parathyroid Hormone with Arterial Function among Older Adults

Circulation ◽  
2014 ◽  
Vol 129 (suppl_1) ◽  
Author(s):  
Adriana J van Ballegooijen ◽  
Ilse Reinders ◽  
Stefan Pilz ◽  
Jacqueline M Dekker ◽  
Giel Nijpels ◽  
...  
Keyword(s):  
Older Adults ◽  
Parathyroid Hormone ◽  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Pulse Wave ◽  
Augmentation Index ◽  
Cross Sectional ◽  
Arterial Function ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D

Introduction: Low vitamin D and high parathyroid hormone (PTH) concentrations have been associated with higher risk of cardiovascular disease in the general population. The mechanisms by which lower 25-hydroxyvitamin D (25OHD) -an established marker of vitamin D status- and PTH excess may confer vascular risk remain largely unknown. Hypothesis: We tested the hypothesis whether lower 25-hydroxyvitamin D (25OHD) and higher parathyroid hormone (PTH) concentrations are individually, and in combination, associated with arterial function measures, both cross-sectionally and after 8 years of follow-up in older adults. Methods: We used data from the Hoorn Study a prospective population-based cohort in the Netherlands. We included 535 participants for cross-sectional analyses with baseline measurements obtained between 2000- 2001, and 291 participants for longitudinal analyses with follow-up measurements obtained between 2007-2009. Serum 25OHD and intact PTH concentrations were measured using immunoassays. Outcomes were carotid-femoral pulse wave velocity and augmentation index. We used multivariate linear regression analyses for season-and-sex specific 25OHD and PTH quartiles to calculate regression coefficients. Results: Mean age at baseline was 70±6.3 years, and 50% were female. Median 25OHD was 54.2 nmol/L (interquartile range: 26.2-82.2) and median PTH 6.1 pmol/L (3.8-8.4). Mean pulse wave velocity and augmentation index were 10.0±3.0 (m/s) and 20.7±8.2 (%), respectively. In cross-sectional analyses, the lowest 25OHD quartile compared with the highest was associated with greater pulse wave velocity; however, the associations attenuated after adjustments 0.6 (95% CI -0.1, 1.3). In longitudinal analyses, neither 25OHD nor PTH was associated with greater pulse wave velocity and augmentation index. The results of the combination of low 25OHD and high PTH revealed no significant associations with arterial function measures. Conclusions: Among older adults, serum 25OHD and PTH concentrations were not associated with arterial function measures. Cardiovascular risk associated with low 25OHD and high PTH may not be explained by arterial stiffening or wave reflections.

Cut off value of plasma 25-hydroxyvitamin D concentration for predicting metabolic syndrome

2019 ◽  
pp. 68-73
Author(s):  
Trong Nghia Nguyen ◽  
Thi Nhan Nguyen ◽  
Thi Dua Dao
Keyword(s):  
Metabolic Syndrome ◽  
Medical Center ◽  
Cross Sectional Study ◽  
Control Group ◽  
Cross Sectional ◽  
Hydroxyvitamin D ◽  
The Metabolic Syndrome ◽  
25 Hydroxyvitamin D ◽  
Key Words Metabolic Syndrome ◽  
And Control

Background: The metabolic syndrome is a constellation of cardiometabolic risk factors that tend to cluster together in affected individuals more often than predicted by chance. The presence of the metabolic syndrome substantially increases the risk of developing type 2 diabetes and cardiovascular disease, and is associated with a range of adverse clinical outcomes, many of which are closely associated with aging. Current estimates suggest that approximately 20 - 25% of the world’s population is affected by the metabolic syndrome. The prevalence of the metabolic syndrome rises with age and more than 45% of people aged over 60 years have the metabolic syndrome. Recent studies show that low vitamin D status is very common in the world and this is a risk factor of metabolic syndrome. Objective: (1) Plasma 25-hydroxyvitamin D concentration in subjects with metabolic syndrome. (2) Cut off value of plasma 25-hydroxyvitamin D concentration for predicting metabolic syndrome. Material and method: A cross-sectional study with control group on 318 adult subjects for health examinations at International Medical Center at Hue Central Hospital, including 139 subjects with metabolic syndrome and control group of 179 healthy subjects. Metabolic syndrome was defined according to the IDF, NHLBI, AHA, WHF, IAS, IASO (2009). Plasma hydroxyvitamin D concentration was measured using chemiluminescent microparticle immunoassay. Reciever operating characteristic (ROC) curve were generated to assess sensitivity and specificity for different cut off value of 25-hydroxyvitamin D concentration for predicting metabolic syndrome. Results: Plasma 25-hydroxyvitamin D concentration in subjects with metabolic syndrome was 26.4 ng/ml, incidence of plasma 25-hydroxyvitamin D deficiency (59.7%) was significantly higher than in control group (23.5%) (p < 0.001). The optimal cut off point for 25-OH-D concentration for predictor of metabolic syndrome as 26.4 ng/ml (AUC=0.657, sensitivity=53.4%, specificity=71.6%). Conclusion: In 139 subjects with metabolic syndrome, the plasma 25-hydroxyvitamin D concentration was 26.4 ng/ml and the incidence of 25-hydroxyvitamin D deficiency in the metabolic syndrome group was 59.7%. The optimal cut off point for plasma 25-hydroxyvitamin D concentration for predictor of metabolic syndrome as 26.4 ng/ml. Key words: Metabolic syndrome, 25-hydroxyvitamin D

Sign in / Sign up

Export Citation Format

Share Document