scholarly journals The effects of aging, physical training, and a single bout of exercise on mitochondrial protein expression in human skeletal muscle

2012 ◽  
Vol 47 (6) ◽  
pp. 417-424 ◽  
Author(s):  
Zoltan Bori ◽  
Zhongfu Zhao ◽  
Erika Koltai ◽  
Ioannis G. Fatouros ◽  
Athanasios Z. Jamurtas ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Protein Expression ◽  
Physical Training ◽  
Human Skeletal Muscle ◽  
Mitochondrial Protein ◽  
Single Bout ◽  
Effects Of Aging

scholarly journals Antioxidants Facilitate High–intensity Exercise IL–15 Expression in Skeletal Muscle

2018 ◽  
Vol 40 (01) ◽  
pp. 16-22 ◽  
Author(s):  
Alberto Pérez-López ◽  
Marcos Martin-Rincon ◽  
Alfredo Santana ◽  
Ismael Perez-Suarez ◽  
Cecilia Dorado ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Protein Expression ◽  
High Intensity ◽  
Human Skeletal Muscle ◽  
Vastus Lateralis ◽  
Acute Hypoxia ◽  
High Intensity Exercise ◽  
Oxygen Deficit ◽  
Post Exercise ◽  
Sprint Exercise

AbstractInterleukin (IL)-15 stimulates mitochondrial biogenesis, fat oxidation, glucose uptake and myogenesis in skeletal muscle. However, the mechanisms by which exercise triggers IL-15 expression remain to be elucidated in humans. This study aimed at determining whether high-intensity exercise and exercise-induced RONS stimulate IL-15/IL-15Rα expression and its signaling pathway (STAT3) in human skeletal muscle. Nine volunteers performed a 30-s Wingate test in normoxia and hypoxia (PIO2=75 mmHg), 2 h after placebo or antioxidant administration (α-lipoic acid, vitamin C and E) in a randomized double-blind design. Blood samples and muscle biopsies (vastus lateralis) were obtained before, immediately after, and 30 and 120 min post-exercise. Sprint exercise upregulated skeletal muscle IL-15 protein expression (ANOVA, P=0.05), an effect accentuated by antioxidant administration in hypoxia (ANOVA, P=0.022). In antioxidant conditions, the increased IL-15 expression at 120 min post-exercise (33%; P=0.017) was associated with the oxygen deficit caused by the sprint (r=–0.54; P=0.020); while, IL-15 and Tyr705-STAT3 AUCs were also related (r=0.50; P=0.036). Antioxidant administration promotes IL-15 protein expression in human skeletal muscle after sprint exercise, particularly in severe acute hypoxia. Therefore, during intense muscle contraction, a reduced PO2 and glycolytic rate, and possibly, an attenuated RONS generation may facilitate IL-15 production, accompanied by STAT3 activation, in a process that does not require AMPK phosphorylation.

scholarly journals Immobilization Decreases FOXO3a Phosphorylation and Increases Autophagy-Related Gene and Protein Expression in Human Skeletal Muscle

2019 ◽  
Vol 10 ◽  
Author(s):  
Andreas Buch Møller ◽  
Mikkel Holm Vendelbo ◽  
Peter Schjerling ◽  
Christian Couppé ◽  
Niels Møller ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Protein Expression ◽  
Human Skeletal Muscle ◽  
Related Gene ◽  
Gene And Protein Expression

Induction of insulin resistance in human skeletal muscle cells by downregulation of glycogen synthase protein expression

Metabolism ◽  
2000 ◽  
Vol 49 (8) ◽  
pp. 962-968 ◽  
Author(s):  
K.S. Park ◽  
T.P. Ciaraldi ◽  
L. Carter ◽  
S. Mudaliar ◽  
S.E. Nikoulina ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Skeletal Muscle ◽  
Protein Expression ◽  
Human Skeletal Muscle ◽  
Glycogen Synthase ◽  
Muscle Cells ◽  
Skeletal Muscle Cells ◽  
Human Skeletal Muscle Cells

A single bout of exercise activates matrix metalloproteinase in human skeletal muscle

2007 ◽  
Vol 21 (5) ◽  
Author(s):  
Eric Rullman ◽  
Helene Rundqvist ◽  
Dick Wågsäter ◽  
Helene Fischer ◽  
Per Eriksson ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Matrix Metalloproteinase ◽  
Human Skeletal Muscle ◽  
Single Bout
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