Age-related changes in superoxide dismutase, glutathione peroxidase, catalase and xanthine oxidoreductase/xanthine oxidase activities in the rabbit cornea

2004 ◽  
Vol 39 (10) ◽  
pp. 1537-1543 ◽  
Author(s):  
Jitka Čejková ◽  
Martin Vejražka ◽  
Jan Pláteník ◽  
Stanislav Štípek
Keyword(s):  
Superoxide Dismutase ◽  
Glutathione Peroxidase ◽  
Xanthine Oxidase ◽  
Xanthine Oxidoreductase ◽  
Rabbit Cornea ◽  
Age Related ◽  
Age Related Changes

scholarly journals Differences in activities of antioxidant superoxide dismutase, glutathione peroxidase and prooxidant xanthine oxidoreductase/xanthine oxidase in the normal corneal epithelium of various mammals

2007 ◽  
pp. 105-112
Author(s):  
J Kovačeva ◽  
J Pláteník ◽  
M Vejražka ◽  
S Štípek ◽  
T Ardan ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Glutathione Peroxidase ◽  
Xanthine Oxidase ◽  
Peroxidase Activity ◽  
Corneal Epithelium ◽  
Guinea Pigs ◽  
Superoxide Dismutase Activity ◽  
Xanthine Oxidoreductase ◽  
Glutathione Peroxidase Activity ◽  
Oxidoreductase Activity

Under normal conditions, antioxidants at the corneal surface are balanced with the production of reactive oxygen species without any toxic effects. Danger from oxidative stress appears when natural antioxidants are overwhelmed leading to antioxidant/prooxidant imbalance. The aim of the present study was to examine the activities of enzymes contributing to the antioxidant/prooxidant balance in normal corneal epithelium of various mammals. The enzyme activities of antioxidant superoxide dismutase and glutathione peroxidase, as well as prooxidant xanthine oxidoreductase/xanthine oxidase were examined using biochemical methods. Results show that superoxide dismutase activity is high in rabbits and guinea pigs, whereas in pigs the activity is low and in cows it is nearly absent. In contrast, glutathione peroxidase activity is high in cows, pigs and rabbits, whereas in guinea pigs the activity is low. As far as prooxidant enzymes are concerned, elevated xanthine oxidoreductase/xanthine oxidase activities were found in rabbits, lower activities in guinea pigs, very low activity in cows and no activity in pigs. In conclusion, the above results demonstrate inter-species variations in activities of enzymes participating in antioxidant/prooxidant balance in the corneal epithelium. It is suggested that the levels of antioxidant and prooxidant enzymes studied in the corneal epithelium might be associated with the diurnal or nocturnal activity of animals. UV rays decompose hydrogen peroxide to damaging hydroxyl radicals and perhaps for this reason large animals with diurnal activity (cow, pig) require more effective peroxide removal (high glutathione peroxidase activity) together with the suppression of peroxide production (low superoxide dismutase activity, low xanthine oxidoreductase activity).

Plasma xanthine oxidase, superoxide dismutase and glutathione peroxidase activities and uric acid levels in severe and mild pre-eclampsia

2004 ◽  
Vol 22 (4) ◽  
pp. 213-217 ◽  
Author(s):  
Abdulkadir Yildirim ◽  
Konca Altinkaynak ◽  
Hulya Aksoy ◽  
Y. Nuri Sahin ◽  
Fatih Akcay
Keyword(s):  
Superoxide Dismutase ◽  
Uric Acid ◽  
Glutathione Peroxidase ◽  
Xanthine Oxidase

Age-related changes in peroxisomal membrane protein 70 and superoxide dismutase 1 in transgenic G93A mice

2003 ◽  
Vol 25 (4) ◽  
pp. 423-426 ◽  
Author(s):  
Hristelina S. Ilieva ◽  
Isao Nagano ◽  
Tetsuro Murakami ◽  
Mito Shiote ◽  
Yasuhiro Manabe ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Membrane Protein ◽  
Superoxide Dismutase 1 ◽  
Peroxisomal Membrane ◽  
Peroxisomal Membrane Protein ◽  
Age Related ◽  
Age Related Changes

Age-related changes in the binding and uptake of Cu, Zn superoxide dismutase in rat liver cells

1996 ◽  
Vol 90 (1) ◽  
pp. 21-33 ◽  
Author(s):  
Luciana Dini ◽  
Luisa Rossi ◽  
Eliana Marchese ◽  
Maria Teresa Ruzittu ◽  
Giuseppe Rotilio
Keyword(s):  
Superoxide Dismutase ◽  
Rat Liver ◽  
Liver Cells ◽  
Age Related ◽  
Rat Liver Cells ◽  
Age Related Changes
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