scholarly journals Biomechanical relationships between the corneal endothelium and Descemet's membrane

2016 ◽  
Vol 152 ◽  
pp. 57-70 ◽  
Author(s):  
Maryam Ali ◽  
VijayKrishna Raghunathan ◽  
Jennifer Y. Li ◽  
Christopher J. Murphy ◽  
Sara M. Thomasy
Keyword(s):  
Corneal Endothelium ◽  
Descemet's Membrane ◽  
Descemet’S Membrane

Aging changes of mouse corneal endothelium and Descemet's membrane

2006 ◽  
Vol 83 (4) ◽  
pp. 890-896 ◽  
Author(s):  
Albert S. Jun ◽  
Shukti Chakravarti ◽  
Henry F. Edelhauser ◽  
Martha Kimos
Keyword(s):  
Corneal Endothelium ◽  
Descemet's Membrane ◽  
Descemet’S Membrane

scholarly journals The spatial organization of Descemet's membrane-associated type IV collagen in the avian cornea.

1990 ◽  
Vol 110 (4) ◽  
pp. 1457-1468 ◽  
Author(s):  
J M Fitch ◽  
D E Birk ◽  
C Linsenmayer ◽  
T F Linsenmayer
Keyword(s):  
Immunoelectron Microscopy ◽  
Corneal Endothelium ◽  
Spatial Organization ◽  
Type Iv Collagen ◽  
Amorphous Material ◽  
Corneal Stroma ◽  
Spatial Arrangement ◽  
Type Iv ◽  
Descemet's Membrane ◽  
Descemet’S Membrane

The organization of type IV collagen in the unconventional basement membrane of the corneal endothelium (Descemet's membrane) was investigated in developing chicken embryos using anti-collagen mAbs. Both immunofluorescence histochemistry and immunoelectron microscopy were performed. In mature embryos (greater than 15 d of development), the type IV collagen of Descemet's membrane was present as an array of discrete aggregates of amorphous material at the interface between Descemet's membrane and the posterior corneal stroma. Immunoreactivity for type IV collagen was also observed in the posterior corneal stroma as irregular plaques of material with a morphology similar to that of the Descemet's membrane-associated aggregates. This arrangement of Descemet's membrane-associated type IV collagen developed from a subendothelial mat of type IV collagen-containing material. This mat, in which type IV collagen-specific immunoreactivity was always discontinuous, first appeared at the time a confluent endothelium was established, well before the onset of Descemet's membrane formation. Immunoelectron microscopy of mature corneas revealed that the characteristic nodal matrix of Descemet's membrane itself was unreactive for type IV collagen, but was penetrated at intervals by projections of type IV collagen-containing material. These projections frequently appeared to contact cell processes from the underlying corneal endothelium. This spatial arrangement of type IV collagen suggests that it serves to suture the corneal endothelium/Descemet's membrane to the dense interfacial matrix of the posterior stroma.

scholarly journals Effect of vital dyes on human corneal endothelium and elasticity of Descemet’s membrane

PLoS ONE ◽  
2017 ◽  
Vol 12 (9) ◽  
pp. e0184375 ◽  
Author(s):  
Isabell P. Weber ◽  
Mrinal Rana ◽  
Peter B. M. Thomas ◽  
Ivan B. Dimov ◽  
Kristian Franze ◽  
...  
Keyword(s):  
Corneal Endothelium ◽  
Human Corneal Endothelium ◽  
Vital Dyes ◽  
Descemet's Membrane ◽  
Descemet’S Membrane

Morphologic Evaluation of Descemet's Membrane and Corneal Endothelium in Diabetes Mellitus

Ophthalmology ◽  
1989 ◽  
Vol 96 (2) ◽  
pp. 247-250 ◽  
Author(s):  
Debra J. Shetlar ◽  
William M. Bourne ◽  
R. Jean Campbell
Keyword(s):  
Diabetes Mellitus ◽  
Corneal Endothelium ◽  
Descemet's Membrane ◽  
Descemet’S Membrane

scholarly journals Use of biomaterials in corneal endothelial repair

2021 ◽  
Vol 13 ◽  
pp. 251584142110582
Author(s):  
Noor Ahmed Hussain ◽  
Francisco C. Figueiredo ◽  
Che J. Connon
Keyword(s):  
Corneal Endothelium ◽  
Surgical Techniques ◽  
Single Layer ◽  
Endothelial Keratoplasty ◽  
Eye Banks ◽  
Clear Vision ◽  
Corneal Grafting ◽  
Descemet's Membrane ◽  
Descemet’S Membrane

Human corneal endothelium (HCE) is a single layer of hexagonal cells that lines the posterior surface of the cornea. It forms the barrier that separates the aqueous humor from the rest of the corneal layers (stroma and epithelium layer). This layer plays a fundamental role in maintaining the hydration and transparency of the cornea, which in turn ensures a clear vision. In vivo, human corneal endothelial cells (HCECs) are generally believed to be nonproliferating. In many cases, due to their nonproliferative nature, any damage to these cells can lead to further issues with Descemet’s membrane (DM), stroma and epithelium which may ultimately lead to hazy vision and blindness. Endothelial keratoplasties such as Descemet’s stripping automated endothelial keratoplasty (DSAEK) and Descemet’s membrane endothelial keratoplasty (DEK) are the standard surgeries routinely used to restore vision following endothelial failure. Basically, these two similar surgical techniques involve the replacement of the diseased endothelial layer in the center of the cornea by a healthy layer taken from a donor cornea. Globally, eye banks are facing an increased demand to provide corneas that have suitable features for transplantation. Consequently, it can be stated that there is a significant shortage of corneal grafting tissue; for every 70 corneas required, only 1 is available. Nowadays, eye banks face long waiting lists due to shortage of donors, seriously aggravated when compared with previous years, due to the global COVID-19 pandemic. Thus, there is an urgent need to find alternative and more sustainable sources for treating endothelial diseases, such as utilizing bioengineering to use of biomaterials as a remedy. The current review focuses on the use of biomaterials to repair the corneal endothelium. A range of biomaterials have been considered based on their promising results and outstanding features, including previous studies and their key findings in the context of each biomaterial.

Solute permeability of the corneal endothelium and Descemet's membrane

1971 ◽  
Vol 12 (3) ◽  
pp. 231-238 ◽  
Author(s):  
Jae Ho Kim ◽  
Keith Green ◽  
Miguel Martinez ◽  
David Paton
Keyword(s):  
Corneal Endothelium ◽  
Solute Permeability ◽  
Descemet's Membrane ◽  
Descemet’S Membrane
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