Possibility of inducing anterior chamber-associated immune deviation by TGF-β2 treatment of monocytes isolated from Behcet's patients

2006 ◽  
Vol 83 (4) ◽  
pp. 981-988 ◽  
Author(s):  
Masaru Takeuchi ◽  
Hiroshi Keino ◽  
Jun Suzuki ◽  
Yoshihiko Usui ◽  
Takaaki Hattori ◽  
...  
Keyword(s):  
Anterior Chamber ◽  
Immune Deviation

Relationship of the Strain and the Intraocular Amount of Herpes Simplex Virus Types 1 and 2 in the Induction of Anterior-Chamber-Associated Immune Deviation

1996 ◽  
Vol 28 (5) ◽  
pp. 289-295 ◽  
Author(s):  
Mariko Akiba ◽  
Itsuro Yoshida ◽  
Tatsuo Suzutani ◽  
Masahiro Ogasawara ◽  
Masanobu Azuma
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Anterior Chamber ◽  
Immune Deviation ◽  
Simplex Virus ◽  
Relationship Of

Splenic CD8+ T cells secrete TGF-β1 to exert suppression in mice with anterior chamber-associated immune deviation

2008 ◽  
Vol 247 (1) ◽  
pp. 87-92 ◽  
Author(s):  
Liqiong Jiang ◽  
Hao He ◽  
Peizeng Yang ◽  
Xiaomin Lin ◽  
Hongyan Zhou ◽  
...  
Keyword(s):  
T Cells ◽  
Anterior Chamber ◽  
Cd8 T Cells ◽  
Immune Deviation ◽  
Tgf Β1

scholarly journals Anterior Chamber-Associated Immune Deviation (ACAID): An Acute Response to Ocular Insult Protects from Future Immune-Mediated Damage?

2009 ◽  
Vol 1 ◽  
pp. OED.S2858 ◽  
Author(s):  
Robert E. Cone ◽  
Roshan Pais
Keyword(s):  
Immune Response ◽  
Anterior Chamber ◽  
Defense Mechanisms ◽  
Immune Defense ◽  
Ocular Tissue ◽  
Immune Deviation ◽  
Acute Response ◽  
Cell Mediated Immune Response ◽  
A Cell ◽  
Humoral Responses

The “immune privilege” that inhibits immune defense mechanisms that could lead to damage to sensitive ocular tissue is based on the expression of immunosuppressive factors on ocular tissue and in ocular fluids. In addition to this environmental protection, the injection of antigen into the anterior chamber or infection in the anterior chamber induces a systemic suppression of potentially damaging cell-mediated and humoral responses to the antigen. Here we discuss evidence that suggests that Anterior Chamber-Associated Immune Deviation (ACAID)a is initiated by an ocular response to moderate inflammation that leads to a systemic immunoregulatory response. Injection into the anterior chamber induces a rise in TNF-α and MCP-1 in aqueous humor and an infiltration of circulating F4/80+ monocytes that home to the iris. The induction of ACAID is dependent on this infiltration of circulating monocytes that eventually emigrate to the thymus and spleen where they induce regulatory T cells that inhibit the inductive or effector phases of a cell-mediated immune response. ACAID therefore protects the eye from the collateral damage of an immune response to infection by suppressing a future potentially damaging response to infection.

scholarly journals Upregulation of CD94 on CD8+T Cells in Anterior Chamber-Associated Immune Deviation

2008 ◽  
Vol 9 (1) ◽  
pp. 53 ◽  
Author(s):  
Hao He ◽  
Peizeng Yang ◽  
Liqiong Jiang ◽  
Junfeng Zhang ◽  
Changlin Zhao ◽  
...  
Keyword(s):  
T Cells ◽  
Anterior Chamber ◽  
Cd8 T Cells ◽  
Immune Deviation
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