Desmethylanhydroicaritin isolated from Sophora flavescens , shows antitumor activities in U87MG cells via inhibiting the proliferation, migration and invasion

2016 ◽  
Vol 43 ◽  
pp. 140-148 ◽  
Author(s):  
Chang-Won Kang ◽  
Nan-Hee Kim ◽  
Huyn Ah Jung ◽  
Hyung-Wook Choi ◽  
Min-Jae Kang ◽  
...  
Keyword(s):  
Migration And Invasion ◽  
Sophora Flavescens ◽  
Antitumor Activities

scholarly journals Molecular Insights into Tumor Targeted Therapy by Carrier-Free Lycorine Nanoparticles in Vitro and in Vivo

2021 ◽  
Author(s):  
Shiyue Zhou ◽  
Yuling Qiu ◽  
Rui Liu ◽  
Shuangshuang Yin ◽  
Yingying Shao ◽  
...  
Keyword(s):  
Blood Circulation ◽  
Therapeutic Strategy ◽  
Aqueous Solubility ◽  
Migration And Invasion ◽  
Antitumor Activities ◽  
Treatment Results ◽  
Carrier Free ◽  
Better Than

Abstract Lycorine (Ly) is a promising natural compound with extensive antitumor activities. However, due to poor aqueous solubility and low bioavailability, the research and development of Ly anticancer drugs has been greatly restricted. Recently, the carrier-free nanoparticles have emerged as an outstanding drug delivery system. In this study, we prepared a DSPE-PEG modifying Ly nanoparticle (DS-Ly NPs) to overcome these drawbacks. We find that compared with Ly, DS-Ly NPs can significantly inhibit cell viability. Meanwhile, DS-Ly NPs treatment results in higher promotion of apoptotic and autophagic capacities, as well as inhibition of migration and invasion. Furthermore, DS-Ly NPs exhibits a better antitumor effect in AOM/DSS induced colorectal tumors and orthotopic hepatocellular tumors than Ly in repression of multiple oncogenic processes, which may benefit from the advantages of carrier-free nanoparticle. Beside, we showed that DS-Ly NPs can prolong the blood circulation time better than Ly. Taken together, these results have demonstrated that carrier-free nanoparticle provides a new therapeutic strategy for treating cancer.

scholarly journals Antitumor Activities of Kushen: Literature Review

2012 ◽  
Vol 2012 ◽  
pp. 1-11 ◽  
Author(s):  
Mingyu Sun ◽  
Hongyan Cao ◽  
Lin Sun ◽  
Shu Dong ◽  
Yanqin Bian ◽  
...  
Keyword(s):  
Antitumor Agents ◽  
Inflammatory Diseases ◽  
Sophora Flavescens ◽  
Antitumor Activities ◽  
Total Alkaloids ◽  
Significant Toxicity ◽  
History Of ◽  
History Of Use

To discover and develop novel natural compounds with therapeutic selectivity or that can preferentially kill cancer cells without significant toxicity to normal cells is an important area in cancer chemotherapy. Kushen, the dried roots ofSophora flavescensAiton, has a long history of use in traditional Chinese medicine to treat inflammatory diseases and cancer. Kushen alkaloids (KS-As) and kushen flavonoids (KS-Fs) are well-characterized components in kushen. KS-As containing oxymatrine, matrine, and total alkaloids have been developed in China as anticancer drugs. More potent antitumor activities were identified in KS-Fs than in KS-Asin vitroandin vivo. KS-Fs may be developed as novel antitumor agents.

723: Chemokine Receptor CXCR4 Mediates Migration and Invasion of Bladder Cancer Cells

2004 ◽  
Vol 171 (4S) ◽  
pp. 192-192 ◽  
Author(s):  
Margitta Retz ◽  
Sukhvinder S. Sidhu ◽  
Gregory M. Dolganov ◽  
Jan Lehmann ◽  
Peter R. Carroll ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Cancer Cells ◽  
Chemokine Receptor ◽  
Migration And Invasion ◽  
Chemokine Receptor Cxcr4 ◽  
Bladder Cancer Cells

Antitumor activities of some Bellis perennis L. fractions

Planta Medica ◽  
2010 ◽  
Vol 76 (12) ◽  
Author(s):  
F Pehlivan Karakas ◽  
A Ucar Turker ◽  
F Yalçin ◽  
I Çalis
Keyword(s):  
Antitumor Activities

Phytoestrogenic activity of Sophora flavescens extract and its constituents

Planta Medica ◽  
2011 ◽  
Vol 77 (12) ◽  
Author(s):  
C Erdelmeier ◽  
H Hauer ◽  
E Koch
Keyword(s):  
Sophora Flavescens

The Migration of Human Smooth Muscle Cells In Vitro Is Mediated by Plasminogen Activation and Can Be Inhibited by α2-Macroglobulin Receptor Associated Protein

1997 ◽  
Vol 78 (02) ◽  
pp. 880-886 ◽  
Author(s):  
Monique J Wijnberg ◽  
Paul H A Quax ◽  
Nancy M E Nieuwenbroek ◽  
Jan H Verheijen
Keyword(s):  
Smooth Muscle ◽  
Cell Migration ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Ldl Receptor ◽  
Migration And Invasion ◽  
Invasion Assay ◽  
Plasminogen Activation ◽  
Smooth Muscle Cell Migration

SummaryThe plasminogen activation system is thought to be important in cell migration processes. A role for this system during smooth muscle cell migration after vascular injury has been suggested from several animal studies. However, not much is known about its involvement in human vascular remodelling. We studied the involvement of the plasminogen activation system in human smooth muscle cell migration in more detail using an in vitro wound assay and a matrix invasion assay. Inhibition of plasmin activity or inhibition of urokinase-type plasminogen activator (u-PA) activity resulted in approximately 40% reduction of migration after 24 h in the wound assay and an even stronger reduction (70-80%) in the matrix invasion assay. Migration of smooth muscle cells in the presence of inhibitory antibodies against tissue-type plasminogen activator (t-PA) was not significantly reduced after 24 h, but after 48 h a 30% reduction of migration was observed, whereas in the matrix invasion assay a 50% reduction in invasion was observed already after 24 h. Prevention of the interaction of u-PA with cell surface receptors by addition of soluble u-PA receptor or α2-macroglobulin receptor associated protein (RAP) to the culture medium, resulted in a similar inhibition of migration and invasion. From these results it can be concluded that both u-PA and t-PA mediated plasminogen activation can contribute to in vitro human smooth muscle cell migration and invasion. Furthermore, the interaction between u-PA and its cell surface receptor appears also to be involved in this migration and invasion process. The inhibitory effects on migration and invasion by the addition of RAP suggests an involvement of a RAP sensitive receptor of the LDL receptor family, possibly the LDL-receptor related protein (LRP) and/or the VLDL receptor.

Evaluation of Antioxidant and Antitumor Activities of Some Prepared Nitrogen Heterocycles

2011 ◽  
Vol 3 (7) ◽  
pp. 106-110
Author(s):  
Mohamed Abd El-Moneim ◽  
◽  
Ibrahim M El-Deen ◽  
Wessam Abd El-Fattah
Keyword(s):  
Nitrogen Heterocycles ◽  
Antitumor Activities
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